Chelsea Kidwell
Professor, Medical Imaging
Professor, Neurology
Professor, BIO5 Institute
Primary Department
Department Affiliations
(520) 626-7159
Work Summary
Chelsea Kidwell specializes in prevention and treatment of stroke. She has special interests in medical imaging and stroke as well as ethnic and racial disparities among stroke patients.
Research Interest
Dr. Kidwell is Professor of Neurology and Medical Imaging and Vice Chair of Research in the Department of Neurology. Dr. Kidwell's clinical research focuses on 1) innovative neuroimaging approaches directed at understanding stroke pathophysiology and treatment, 2) reducing health disparities in stroke care, and 3) advancing novel treatments for acute stroke including intracerebral hemorrhage. Dr. Kidwell is the author of over 100 peer-reviewed journal publications and 15 book chapters.

Publications

Qureshi, A. I., Palesch, Y. Y., Barsan, W. G., Hanley, D. F., Hsu, C. Y., Martin, R. L., Moy, C. S., Silbergleit, R., Steiner, T., Suarez, J. I., Toyoda, K., Wang, Y., Yamamoto, H., & Yoon, B. W. (2016). Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage. The New England journal of medicine, 375(11), 1033-43.
BIO5 Collaborators
Kurt R Denninghoff, Chelsea Kidwell

Background Limited data are available to guide the choice of a target for the systolic blood-pressure level when treating acute hypertensive response in patients with intracerebral hemorrhage. Methods We randomly assigned eligible participants with intracerebral hemorrhage (volume,

Ovbiagele, B., & Kidwell, C. S. (2013). Response to letter regarding article, "Association of chronic kidney disease with cerebral microbleeds in patients with primary intracerebral hemorrhage". Stroke, 44(12), e232.
Saver, J. L., Jovin, T. G., Smith, W. S., Albers, G. W., Baron, J. C., Boltze, J., Broderick, J. P., Davis, L. A., Demchuk, A. M., DeSena, S., Fiehler, J., Gorelick, P. B., Hacke, W., Holt, B., Jahan, R., Jing, H., Khatri, P., Kidwell, C. S., Lees, K. R., , Lev, M. H., et al. (2013). Stroke treatment academic industry roundtable: research priorities in the assessment of neurothrombectomy devices. Stroke, 44(12), 3596-601.

The goal of the Stroke Treatment Academic Industry Roundtable (STAIR) meetings is to advance the development of stroke therapies. At STAIR VIII, consensus recommendations were developed for clinical trial strategies to demonstrate the benefit of endovascular reperfusion therapies for acute ischemic stroke.

Kidwell, C. S., & Jahan, R. (2015). Endovascular treatment of acute ischemic stroke. Neurologic clinics, 33(2), 401-20.

Endovascular therapy for acute stroke has evolved with the use of intra-arterial thrombolytics, intravenous/intra-arterial bridging strategies, and mechanical thrombectomy/aspiration devices. Despite widespread use in clinical practice, randomized trials of first-generation devices failed to demonstrate improved outcomes compared with standard care. New-generation stent retriever devices demonstrate higher rates of revascularization and clinical outcomes compared with first-generation devices. Additional randomized trials are underway and have the potential to confirm clinical efficacy of new-generation devices compared with standard care. The role of additional advanced imaging for patient selection remains unclear, and further trials are needed to demonstrate the role of these techniques for patient selection.

Woo, D., Falcone, G. J., Devan, W. J., Brown, W. M., Biffi, A., Howard, T. D., Anderson, C. D., Brouwers, H. B., Valant, V., Battey, T. W., Radmanesh, F., Raffeld, M. R., Baedorf-Kassis, S., Deka, R., Woo, J. G., Martin, L. J., Haverbusch, M., Moomaw, C. J., Sun, G., , Broderick, J. P., et al. (2014). Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage. American journal of human genetics, 94(4), 511-21.

Intracerebral hemorrhage (ICH) is the stroke subtype with the worst prognosis and has no established acute treatment. ICH is classified as lobar or nonlobar based on the location of ruptured blood vessels within the brain. These different locations also signal different underlying vascular pathologies. Heritability estimates indicate a substantial genetic contribution to risk of ICH in both locations. We report a genome-wide association study of this condition that meta-analyzed data from six studies that enrolled individuals of European ancestry. Case subjects were ascertained by neurologists blinded to genotype data and classified as lobar or nonlobar based on brain computed tomography. ICH-free control subjects were sampled from ambulatory clinics or random digit dialing. Replication of signals identified in the discovery cohort with p