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Professor, Medical Imaging
Professor, BIO5 Institute
Chelsea Kidwell specializes in prevention and treatment of stroke. She has special interests in medical imaging and stroke as well as ethnic and racial disparities among stroke patients.
Dr. Kidwell is Professor of Neurology and Medical Imaging and Vice Chair of Research in the Department of Neurology. Dr. Kidwell's clinical research focuses on 1) innovative neuroimaging approaches directed at understanding stroke pathophysiology and treatment, 2) reducing health disparities in stroke care, and 3) advancing novel treatments for acute stroke including intracerebral hemorrhage. Dr. Kidwell is the author of over 100 peer-reviewed journal publications and 15 book chapters.
Qureshi, A. I., Palesch, Y. Y., Barsan, W. G., Hanley, D. F., Hsu, C. Y., Martin, R. L., Moy, C. S., Silbergleit, R., Steiner, T., Suarez, J. I., Toyoda, K., Wang, Y., Yamamoto, H., & Yoon, B. W. (2016). Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage. The New England journal of medicine, 375(11), 1033-43.
Kurt R Denninghoff, Chelsea Kidwell
Background Limited data are available to guide the choice of a target for the systolic blood-pressure level when treating acute hypertensive response in patients with intracerebral hemorrhage. Methods We randomly assigned eligible participants with intracerebral hemorrhage (volume,
Koch, S., Elkind, M. S., Testai, F. D., Brown, W. M., Martini, S., Sheth, K. N., Chong, J. Y., Osborne, J., Moomaw, C. J., Langefeld, C. D., Sacco, R. L., Woo, D., & , E. S. (2016). Racial-ethnic disparities in acute blood pressure after intracerebral hemorrhage. Neurology, 87(8), 786-91.
To assess race-ethnic differences in acute blood pressure (BP) following intracerebral hemorrhage (ICH) and the contribution to disparities in ICH outcome.
Mackey, J., Wing, J. J., Norato, G., Sobotka, I., Menon, R. S., Burgess, R. E., Gibbons, M. C., Shara, N. M., Fernandez, S., Jayam-Trouth, A., Russell, L., Edwards, D. F., & Kidwell, C. S. (2015). High rate of microbleed formation following primary intracerebral hemorrhage. International journal of stroke : official journal of the International Stroke Society, 10(8), 1187-91.
We sought to investigate the frequency of microbleed development following intracerebral hemorrhage in a predominantly African-American population and to identify predictors of new microbleed formation.
Irvine, H. J., Ostwaldt, A. C., Bevers, M. B., Dixon, S., Battey, T. W., Campbell, B. C., Davis, S. M., Donnan, G. A., Sheth, K. N., Jahan, R., Saver, J. L., Kidwell, C. S., & Kimberly, W. T. (2017). Reperfusion after ischemic stroke is associated with reduced brain edema. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 271678X17720559.
Rapid revascularization is highly effective for acute stroke, but animal studies suggest that reperfusion edema may attenuate its beneficial effects. We investigated the relationship between reperfusion and edema in patients from the Echoplanar Imaging Thrombolysis Evaluation Trial (EPITHET) and Mechanical Retrieval and Recanalization of Stroke Clots Using Embolectomy (MR RESCUE) cohorts. Reperfusion percentage was measured as the difference in perfusion-weighted imaging lesion volume between baseline and follow-up (day 3-5 for EPITHET; day 6-8 for MR RESCUE). Midline shift (MLS) and swelling volume were quantified on follow-up MRI. We found that reperfusion was associated with less MLS (EPITHET: Spearman ρ = -0.46; P
MacIsaac, R. L., Khatri, P., Bendszus, M., Bracard, S., Broderick, J., Campbell, B., Ciccone, A., Dávalos, A., Davis, S. M., Demchuk, A., Diener, H., Dippel, D., Donnan, G. A., Fiehler, J., Fiorella, D., Goyal, M., Hacke, W., Hill, M. D., Jahan, R., , Jauch, E., et al. (2015). A collaborative sequential meta-analysis of individual patient data from randomized trials of endovascular therapy and tPA vs. tPA alone for acute ischemic stroke: ThRombEctomy And tPA (TREAT) analysis: statistical analysis plan for a sequential meta-analysis performed within the VISTA-Endovascular collaboration. International journal of stroke : official journal of the International Stroke Society, 10 Suppl A100, 136-44.
Endovascular treatment has been shown to restore blood flow effectively. Second-generation medical devices such as stent retrievers are now showing overwhelming efficacy in clinical trials, particularly in conjunction with intravenous recombinant tissue plasminogen activator.