Chelsea Kidwell
Professor, Medical Imaging
Professor, Neurology
Professor, BIO5 Institute
Primary Department
Department Affiliations
(520) 626-7159
Work Summary
Chelsea Kidwell specializes in prevention and treatment of stroke. She has special interests in medical imaging and stroke as well as ethnic and racial disparities among stroke patients.
Research Interest
Dr. Kidwell is Professor of Neurology and Medical Imaging and Vice Chair of Research in the Department of Neurology. Dr. Kidwell's clinical research focuses on 1) innovative neuroimaging approaches directed at understanding stroke pathophysiology and treatment, 2) reducing health disparities in stroke care, and 3) advancing novel treatments for acute stroke including intracerebral hemorrhage. Dr. Kidwell is the author of over 100 peer-reviewed journal publications and 15 book chapters.

Publications

Qureshi, A. I., Palesch, Y. Y., Barsan, W. G., Hanley, D. F., Hsu, C. Y., Martin, R. L., Moy, C. S., Silbergleit, R., Steiner, T., Suarez, J. I., Toyoda, K., Wang, Y., Yamamoto, H., & Yoon, B. W. (2016). Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage. The New England journal of medicine, 375(11), 1033-43.
BIO5 Collaborators
Kurt R Denninghoff, Chelsea Kidwell

Background Limited data are available to guide the choice of a target for the systolic blood-pressure level when treating acute hypertensive response in patients with intracerebral hemorrhage. Methods We randomly assigned eligible participants with intracerebral hemorrhage (volume,

Anderson, C. D., Falcone, G. J., Phuah, C. L., Radmanesh, F., Brouwers, H. B., Battey, T. W., Biffi, A., Peloso, G. M., Liu, D. J., Ayres, A. M., Goldstein, J. N., Viswanathan, A., Greenberg, S. M., Selim, M., Meschia, J. F., Brown, D. L., Worrall, B. B., Silliman, S. L., Tirschwell, D. L., , Flaherty, M. L., et al. (2016). Genetic variants in CETP increase risk of intracerebral hemorrhage. Annals of neurology, 80(5), 730-740.

In observational epidemiologic studies, higher plasma high-density lipoprotein cholesterol (HDL-C) has been associated with increased risk of intracerebral hemorrhage (ICH). DNA sequence variants that decrease cholesteryl ester transfer protein (CETP) gene activity increase plasma HDL-C; as such, medicines that inhibit CETP and raise HDL-C are in clinical development. Here, we test the hypothesis that CETP DNA sequence variants associated with higher HDL-C also increase risk for ICH.

Grams, R., Kidwell, S. M., Drake, K. W., Becker, J., Coull, B. M., & Nael, K. (2016). Tissue Negative-Transient Ischemic Attack: Is There a Role for MRI Perfusion?. American Journal of Roentgenology.
Siddiqui, F. M., Langefeld, C. D., Moomaw, C. J., Comeau, M. E., Sekar, P., Rosand, J., Kidwell, C. S., Martini, S., Osborne, J. L., Stutzman, S., Hall, C., & Woo, D. (2017). Use of Statins and Outcomes in Intracerebral Hemorrhage Patients. Stroke, 48(8), 2098-2104.

Statin use may be associated with improved outcome in intracerebral hemorrhage patients. However, the topic remains controversial. Our analysis examined the effect of prior, continued, or new statin use on intracerebral hemorrhage outcomes using the ERICH (Ethnic/Racial Variations of Intracerebral Hemorrhage) data set.

Wintermark, M., Sanelli, P. C., Albers, G. W., Bello, J. A., Derdeyn, C. P., Hetts, S. W., Johnson, M. H., Kidwell, C. S., Lev, M. H., Liebeskind, D. S., Rowley, H. A., Schaefer, P. W., Sunshine, J. L., Zaharchuk, G., Meltzer, C. C., , A. S., , A. C., & , S. o. (2013). Imaging recommendations for acute stroke and transient ischemic attack patients: a joint statement by the American Society of Neuroradiology, the American College of Radiology and the Society of NeuroInterventional Surgery. Journal of the American College of Radiology : JACR, 10(11), 828-32.

In the article entitled "Imaging Recommendations for Acute Stroke and Transient Ischemic Attack Patients: A Joint Statement by the American Society of Neuroradiology, the American College of Radiology and the Society of NeuroInterventional Surgery", we are proposing a simple, pragmatic approach that will allow the reader to develop an optimal imaging algorithm for stroke patients at their institution.