Barton, J. K., Connolly, D. C., Craig, Z. R., Chambers, S. K., Hutchens, G. V., Dominguez Cooks, J. P., Koevary, J. W., Howard, C. C., Rice, P. F., & Hoyer, P. (2018). Comparison of Markers of Reproductive Function in Female C57Bl/6 versus TgMISIIR-TAg Transgenic Mice: Effect of VCD exposure on Ovarian Failure.. Comparative Medicine.
BIO5 Collaborators
Jennifer Kehlet Barton, Zelieann R Craig
Barton, J., Hansen, K. A., Weiss, J. A., & Barton, J. K. (2002). Recruitment of tendon crimp with applied tensile strain. Journal of biomechanical engineering, 124(1).
The tensile stress-strain behavior of ligaments and tendons begins with a toe region that is believed to result from the straightening of crimped collagen fibrils. The in situ mechanical function is mostly confined to this toe region and changes in crimp morphology are believed to be associated with pathological conditions. A relatively new imaging technique, optical coherence tomography (OCT), provides a comparatively inexpensive method for nondestructive investigation of tissue ultrastructure with resolution on the order of 15 microm and the potential for use in a clinical setting. The objectives of this work were to assess the utility of OCT for visualizing crimp period, and to use OCT to determine how crimp period changed as a function of applied tensile strain in rat tail tendon fascicles. Fascicles from rat tail tendons were subjected to 0.5 percent strain increments up to 5 percent and imaged at each increment using OCT. A comparison between OCT images and optical microscopy images taken between crossed polarizing lenses showed a visual correspondence between features indicative of crimp pattern. Crimp pattern always disappeared completely before 3 percent axial strain was reached. Average crimp period increased as strain increased, but both elongation and shortening occurred within single crimp periods during the application of increasing strain to the fascicle.
Tumlinson, A. R., Povazay, B., Hariri, L. P., McNally, J., Unterhuber, A., Hermann, B., Sattmann, H., Drexler, W., & Barton, J. K. (2006). In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope. JOURNAL OF BIOMEDICAL OPTICS, 11(6).
Welge, W., & Barton, J. (2015). MILD TEMPERATURE HYPERTHERMIA INDUCING DOPPLER OPTICAL COHERENCE TOMOGRAPHY ENDOSCOPE FOR EARLY DETECTION OF COLORECTAL CANCER IN A MOUSE MODEL. LASERS IN SURGERY AND MEDICINE, 47, 49-49.
Barton, J., Hariri, L. P., Qiu, Z., Tumlinson, A. R., Besselsen, D. G., Gerner, E. W., Ignatenko, N. A., Povazay, B., Hermann, B., Sattmann, H., McNally, J., Unterhuber, A., Drexler, W., & Barton, J. K. (2007). Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography. Cancer biology & therapy, 6(11).
BIO5 Collaborators
Jennifer Kehlet Barton, David G Besselsen
Optical coherence tomography (OCT) is a minimally invasive, depth-resolved imaging tool that can be implemented in a small diameter endoscope for imaging mouse models of colorectal cancer (CRC). In this study, we utilized ultrahigh resolution (UHR) OCT to serially image the lower colon of azoxymethane (AOM) treated A/J mouse models of CRC in order to monitor the progression of neoplastic transformations and determine if OCT is capable of identifying early disease.
