Kurt R Denninghoff

Professor, Emergency Medicine

Professor, Optical Sciences

Professor, BIO5 Institute

Primary Department

Emergency Medicine

Department Affiliations

Emergency Medicine

BIO5 Institute

Contact

(520) 626-1551

kdenninghoff@aemrc.arizona.edu

Research Interest

Over the last seven years, I have developed an innovative clinical research nursing program, new retinal oximetry techniques including a prototype device called the ROx-3 and a research associate volunteer program. I have been working on improving the prehospital care for children and adults with traumatic brain injury and have been successful organizing a collaborative that is rapidly advancing this field. Recently, I have begun working with others to improve the care of children with asthma presenting to the emergency department. My clinical trials research, clinical device testing, injury control efforts, mentoring and research center leadership experience taken together make me very well suited to serve as the Southwest PECARN Node and Arizona HEDA PI.

Publications

Mortality and Prehospital Blood Pressure in Patients With Major Traumatic Brain Injury: Implications for the Hypotension Threshold

Spaite, D. W., Hu, C., Bobrow, B. J., Chikani, V., Sherrill, D., Barnhart, B., Gaither, J. B., Denninghoff, K. R., Viscusi, C., Mullins, T., & Adelson, P. D. (2017). Mortality and Prehospital Blood Pressure in Patients With Major Traumatic Brain Injury: Implications for the Hypotension Threshold. JAMA surgery, 152(4), 568-74. doi:10.1001/jamasurg.2016.4686

BIO5 Collaborators

Kurt R Denninghoff, Chengcheng Hu

Current prehospital traumatic brain injury guidelines use a systolic blood pressure threshold of less than 90 mm Hg for treating hypotension for individuals 10 years and older based on studies showing higher mortality when blood pressure drops below this level. However, the guidelines also acknowledge the weakness of the supporting evidence.

The Influence of Prehospital Hypotension and Hypoxia on Non-Mortality Outcomes in Patients with Major Traumatic Brain Injury

Spaite, D. W., Stolz, U., Chikani, V., Bobrow, B. J., Sotelo, M., Barnhart, B. J., Denninghoff, K. R., Gaither, J. B., Viscusi, C. D., Adelson, D. P., Sherrill, D. L., & Harden, D. (2016). The Influence of Prehospital Hypotension and Hypoxia on Non-Mortality Outcomes in Patients with Major Traumatic Brain Injury. Prehospital Emergency Care.

Combined Prehospital Hypoxia-Hypotension “Depth-Duration Dose” and Mortality in Major Traumatic Brain Injury

Spaite, D. W., Hu, C., Bobrow, B. J., Chikani, V., Gaither, J. B., Barnhart, B., Adelson, P. D., Denninghoff, K. R., Rice, A. D., Viscusi, C. D., Sherrill, D. L., & Keim, S. M. (2017). Combined Prehospital Hypoxia-Hypotension “Depth-Duration Dose” and Mortality in Major Traumatic Brain Injury. Prehospital Emergency Care.

Spaite DW, Hu C, Bobrow BJ, Chikani V, Gaither JB, Barnhart B, Adelson PD, Denninghoff KR, Rice AD, Viscusi C, Sherrill D, Keim SM: Combined Prehospital Hypoxia-Hypotension “Depth-Duration Dose” and Mortality in Major Traumatic Brain Injury. Prehospital Emerg Care 2018;22(1):105-106.

Impact and feasibility of an emergency department-based ventilator-associated pneumonia bundle for patients intubated in an academic emergency department

DeLuca, L. A., Walsh, P., Davidson, D. D., Stoneking, L. R., Yang, L. M., Grall, K. J., Gonzaga, M. J., Larson, W. J., Stolz, U., Sabb, D. M., & Denninghoff, K. R. (2017). Impact and feasibility of an emergency department-based ventilator-associated pneumonia bundle for patients intubated in an academic emergency department. American journal of infection control, 45(2), 151-157.

Ventilator-associated pneumonia (VAP) has been linked to emergency department (ED) intubation and length of stay (LOS). We assessed VAP prevalence in ED intubated patients, feasibility of ED VAP prevention, and effect on VAP rates.

Damage-control resuscitation and emergency laparotomy: Findings from the PROPPR study

Undurraga Perl, V. J., Leroux, B., Cook, M. R., Watson, J., Fair, K., Martin, D. T., Kerby, J. D., Williams, C., Inaba, K., Wade, C. E., Cotton, B. A., Del Junco, D. J., Fox, E. E., Scalea, T. M., Tilley, B. C., Holcomb, J. B., Schreiber, M. A., & , P. S. (2016). Damage-control resuscitation and emergency laparotomy: Findings from the PROPPR study. The journal of trauma and acute care surgery, 80(4), 568-74; discussion 574-5.

The Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial has demonstrated that damage-control resuscitation, a massive transfusion strategy targeting a balanced delivery of plasma-platelet-red blood cell in a ratio of 1:1:1, results in improved survival at 3 hours and a reduction in deaths caused by exsanguination in the first 24 hours compared with a 1:1:2 ratio. In light of these findings, we hypothesized that patients receiving 1:1:1 ratio would have improved survival after emergency laparotomy.

Kurt R Denninghoff