Kurt R Denninghoff
Professor, BIO5 Institute
Professor, Emergency Medicine
Professor, Optical Sciences
Primary Department
Department Affiliations
(520) 626-1551
Research Interest
Over the last seven years, I have developed an innovative clinical research nursing program, new retinal oximetry techniques including a prototype device called the ROx-3 and a research associate volunteer program. I have been working on improving the prehospital care for children and adults with traumatic brain injury and have been successful organizing a collaborative that is rapidly advancing this field. Recently, I have begun working with others to improve the care of children with asthma presenting to the emergency department. My clinical trials research, clinical device testing, injury control efforts, mentoring and research center leadership experience taken together make me very well suited to serve as the Southwest PECARN Node and Arizona HEDA PI.

Publications

Chikani, V., Spaite, D. W., Smith, J. J., Curry, M., Mhayamagru, M., Barnhart, B. J., Adelson, P. D., Viscusi, C. D., Denninghoff, K. R., Bobrow, B. J., & Gaither, J. B. (2016). Elevated Initial Trauma Center Body Temperatures Are Associated With Poor Non-Mortality Outcomes Following Major Traumatic Brain Injury. Prehospital Emergency Care.
Appel, J. E., Appel, J. E., Farrell, I. J., Farrell, I. J., Stoneking, L. R., Stoneking, L. R., Denninghoff, K. R., & Denninghoff, K. R. (2015). Meta-analysis of point of care D-dimers in the emergency department. Annals of Emergency Medicine.
Spaite, D. W., Hu, C., Bobrow, B. J., Chikani, V., Sherrill, D., Barnhart, B., Gaither, J. B., Denninghoff, K. R., Viscusi, C., Mullins, T., & Adelson, P. D. (2017). Mortality and Prehospital Blood Pressure in Patients With Major Traumatic Brain Injury: Implications for the Hypotension Threshold. JAMA surgery, 152(4), 568-74. doi:10.1001/jamasurg.2016.4686
BIO5 Collaborators
Kurt R Denninghoff, Chengcheng Hu

Current prehospital traumatic brain injury guidelines use a systolic blood pressure threshold of less than 90 mm Hg for treating hypotension for individuals 10 years and older based on studies showing higher mortality when blood pressure drops below this level. However, the guidelines also acknowledge the weakness of the supporting evidence.

Spaite, D. W., Stolz, U., Chikani, V., Bobrow, B. J., Sotelo, M., Barnhart, B. J., Denninghoff, K. R., Gaither, J. B., Viscusi, C. D., Adelson, D. P., Sherrill, D. L., & Harden, D. (2016). The Influence of Prehospital Hypotension and Hypoxia on Non-Mortality Outcomes in Patients with Major Traumatic Brain Injury. Prehospital Emergency Care.
Spaite, D. W., Hu, C., Bobrow, B. J., Chikani, V., Gaither, J. B., Barnhart, B., Adelson, P. D., Denninghoff, K. R., Rice, A. D., Viscusi, C. D., Sherrill, D. L., & Keim, S. M. (2017). Combined Prehospital Hypoxia-Hypotension “Depth-Duration Dose” and Mortality in Major Traumatic Brain Injury. Prehospital Emergency Care.

Spaite DW, Hu C, Bobrow BJ, Chikani V, Gaither JB, Barnhart B, Adelson PD, Denninghoff KR, Rice AD, Viscusi C, Sherrill D, Keim SM: Combined Prehospital Hypoxia-Hypotension “Depth-Duration Dose” and Mortality in Major Traumatic Brain Injury. Prehospital Emerg Care 2018;22(1):105-106.