Monica Kraft
Chair, Department of Medicine
Professor, BIO5 Institute
Professor, Medicine
Primary Department
Department Affiliations
(520) 626-7174
Work Summary
Monica Kraft's research focus is in the areas of adult asthma, the role of infection in asthma and the role of the distal lung in asthma and airway remodeling.
Research Interest
Monica Kraft, MD, is chair of the Department of Medicine at the University of Arizona College of Medicine – Tucson, and the Robert and Irene Flinn Endowed Professor of Medicine.Prior to joining the UA in 2014, Dr. Kraft was at Duke University, where she served as chief of the Division of Pulmonary, Allergy and Critical Care, as the Charles C. Johnson, MD, Distinguished Professor of Medicine, and as director of the Duke Asthma, Allergy and Airway Center. As vice chair for research in the Duke University Department of Medicine from 2009-2013, Dr. Kraft implemented several important initiatives to support the department’s research endeavors and was instrumental in the re-submission and renewal of Duke’s National Institutes of Health-funded Clinical Translational Science Award (CTSA).Dr. Kraft has more than 150 publications in the areas of adult asthma, the role of infection in asthma and the role of the distal lung in asthma and airway remodeling. Her work has appeared in such prestigious publications as the Journal of the American Medical Association, The Lancet, the American Journal of Respiratory and Critical Care Medicine, the Journal of Allergy and Clinical Immunology, and Chest. Her work has been funded by the National Institutes of Health and the American Lung Association.

Publications

Ledford, J., Addison, K., Guerra, S., Rojas Quintero, J., Owen, C., Martinez, F., & Kraft, M. (2016). “Club cell secretory protein deficiency leads to altered lung function in naïve mice. Journal of Allergy and Clinical Immunology.
BIO5 Collaborators
Stefano Guerra, Monica Kraft
Kraft, M., Mortenson, R. L., Colby, T. V., Newman, L., Waldron, J. A., & King, T. E. (1993). Cryptogenic constrictive bronchiolitis. A clinicopathologic study. The American review of respiratory disease, 148(4 Pt 1), 1093-101.

Four women with a chronic respiratory illness characterized by chronic cough, dyspnea, mild to severe physiologic abnormalities, relatively normal chest radiographs, and lack of response to bronchodilators or prednisone were identified and prospectively evaluated. Constrictive bronchiolitis, defined as concentric narrowing of the bronchiolar lumen, mural scarring, smooth muscle hyperplasia, and mucus stasis, was the major histologic finding on open lung biopsy in all cases. Each presented with an illness clinically distinct from asthma, connective tissue disorders, occupational or environmental lung disease, bronchiectasis, diffuse panbronchiolitis, cystic fibrosis, and emphysema. None of the patients smoked cigarettes. None had clinical evidence of a recent viral lower respiratory tract infection. The physical examinations were normal except for rales heard on chest examination in two patients. Chest radiographs showed increased bronchovascular markings in three patients. Lung function was normal in one patient, two of the patients had a reduced diffusing capacity associated with moderate hypoxemia and an obstructive ventilatory defect, and one patient exhibited a mixture of restrictive and obstructive defects. None have experienced significant progression of their disease over 1 to 5 yr of follow-up. However, complete return to normal function did not occur. We hypothesize that patients with the constellation of findings described represent a distinct and definable clinicopathologic entity and further clarifies the spectrum of "small airways disease." Establishing the diagnosis appears important for prognostic and possibly therapeutic reasons.

Lugogo, N. L., & Kraft, M. (2006). Epidemiology of asthma. Clinics in chest medicine, 27(1), 1-15, v.

The epidemiology of asthma is complex but essential in enhancing the understanding of a disease that affects millions of patients. Asthma is associated with significant morbidity and mortality. Asthma prevalence rates in the United States reached a plateau after 1998 with an estimated overall prevalence of 3.8% in 2003. Racial disparities exist and there are staggering differences in morbidity and mortality. The analysis of data collected from epidemiologic studies continues to be a critical part of enhancing the understanding of the pathophysiology of asthma, which will lead to improved patient outcomes.

Sutherland, E. R., Kraft, M., Rex, M. D., Ellison, M. C., & Martin, R. J. (2003). Hypothalamic-pituitary-adrenal axis dysfunction during sleep in nocturnal asthma. Chest, 123(3 Suppl), 405S.
Lemanske, R. F., Sorkness, C. A., Mauger, E. A., Lazarus, S. C., Boushey, H. A., Fahy, J. V., Drazen, J. M., Chinchilli, V. M., Craig, T., Fish, J. E., Ford, J. G., Israel, E., Kraft, M., Martin, R. J., Nachman, S. A., Peters, S. P., Spahn, J. D., Szefler, S. J., & , A. C. (2016). Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. JAMA, 285(20), 2594-603.

Inhaled long-acting beta(2)-agonists improve asthma control when added to inhaled corticosteroid (ICS) therapy.