Scott B Going
Department Head, Nutritional Sciences
Professor, BIO5 Institute
Professor, Nutritional Sciences
Professor, Physiological Sciences - GIDP
Professor, Physiology
Professor, Public Health
Primary Department
Department Affiliations
(520) 626-3432
Work Summary
Scott Going is an expert in models and methods for assessment of changes in body composition during growth, and with aging, and is currently investigating the effects of chronic exercise versus hormone replacement therapy on bone, soft tissue composition and muscle strength in postmenopausal women, as well as the role of exercise in obesity prevention in children.
Research Interest
Current projects include:The Bone, Estrogen and Strength Training (BEST) study, a randomized prospective study of the effects of hormone replacement therapy on bone mineral density, soft tissue composition, and muscle strength in postmenopausal women (National Institutes of Health). The Profile-based Internet-linked Obesity Treatment study (PILOT), a randomized study of internet support for weight maintenance after weight loss in peri-menopausal women (National Institutes of Health). The Trial of Activity for Adolescent Girls (TAAG) study, a multi-center, school-based activity trial designed to prevent the usual decline in physical activity in adolescent girls (National Institutes of Health). The Adequate Calcium Today (ACT) study, a randomized multi-center study of a behavioral intervention to promote healthy eating, calcium intake and bone development in adolescent girls (United States Department of Agriculture). The Healthy Weight in Adolescents study, a randomized, multi-center study of the effects of a science-based curriculum focused on concepts of energy balance on body weight and composition in adolescent boys and girls (United States Department of Agriculture). The KNEE study, a randomized clinical trial of the effects of resistance exercise on disease progression, pain, and functional capacity in osteoarthritis patients (National Institutes of Health). The STRONG study, a randomized clinical trial of the effects of resistance exercise and Remicaid on disease progression, pain, muscle strength and functional capacity in rheumatoid arthritis patients (Centocor, Inc.). Partners for Healthy Active Children, Campañeros Para Niños Sano y Actives, designed to create and implement research-based physical education and nutrition curricula at YMCA after-school programs and Sunnyside District elementary schools, in alignment with the State o Arizona , Health and Physical Activity standards (Carol M. White Physical Education Program CFDA #84.215F). Longitudinal Changes in Hip Geometry, an observational and experimental cohort study of changes in muscle mass, hip structural parameters and hip bone strength in middle-aged and older women in the Women's Healthy Initiative study (National Institutes of Health).

Publications

Going, S. B., Chen, Z., Alexander, G. E., Mandarino, L. J., Garcia, D. O., Bea, J. W., Raichlen, D. A., & Klimentidis, Y. C. (2017). Genome-wide association study of habitual physical activity in over 277,000 UK Biobank participants indentifies novel variants and genetic correlations with chronotype and obesity related traits. International Journal of Obesity.
BIO5 Collaborators
Zhao Chen, Scott B Going, Yann C Klimentidis
Klimentidis, Y. C., Bea, J. W., Lohman, T. G., Hsieh, P. S., Going, S. B., & Chen, Z. (2015). Resistance exercise intervention results in less weight loss among individuals at high genetic risk for obesity. International Journal of Obesity, 39(9), 1371-1375.
BIO5 Collaborators
Zhao Chen, Scott B Going, Yann C Klimentidis
Farr, J. N., Funk, J. L., Chen, Z., Lisse, J. R., Blew, R. M., Lee, V. R., Laudermilk, M., Lohman, T. G., & Going, S. B. (2011). Skeletal Muscle Fat Content Is Inversely Associated With Bone Strength in Young Girls. JOURNAL OF BONE AND MINERAL RESEARCH, 26(9), 2217-2225.
BIO5 Collaborators
Janet L Funk, Scott B Going
Going, S. B., Massey, B. H., Hoshizaki, T. B., & Lohman, T. G. (1987). Maximal voluntary static force production characteristics of skeletal muscle in children 8-11 years of age. Research Quarterly for Exercise and Sport, 58(2), 115-123.

Abstract:

Maximal voluntary isometric muscle contraction force-time curves for 32 normal, healthy children, age 8-11 years, 15 girls and 17 boys, performing three tasks representing separate muscle groups - finger flexors, forearm flexors, and forearm extensors - were recorded over trials and over days. Children's pattern of force production and degree of consistency over trials and days has not been reported in the literature. The primary objective was to identify curve components reproduced with sufficient consistency over trials and days to suggest possible value for providing new and unique information regarding muscle function. Each task was recorded three consecutive trials per day over two days separated by one week. Analog tracings of instantaneous and integrated force were obtained using a Daytronic Linear Voltage Transformer in series with a Brush Mark 280 recorder. Trial to trial and day to day consistency in force production by each muscle group represented by 14 curve variables was assessed using intraclass correlation based on a days x trials x subjects ANOVA for each variable. Force and maximal rate of force increase were quite reproducible; but time to selected force levels reflected considerable variation. The force variables - maximal force, force at which the curve plateaued, and force at the point of curve inflection - intercorrelated well, but correlated only moderately with maximum rate of force increase, and poorly with the time variables. Maximal rate of force increase gave the most promise of providing new information regarding muscle function in children.

Going, S. B. (2010). Physical activity measurements: lessons learned from the pathways study. Journal of public health management and practice : JPHMP, 16(5).

High obesity rates in American Indian children led to Pathways, a randomized school- and community-based childhood prevention study. Seven tribes, 5 universities, the National Institutes of Health/National Heart, Lung, and Blood Institute, and 4 elementary schools partnered in the study. Increasing physical activity (PA) was an important intervention target. The PA assessment was based on study objectives, feasibility, and tribal acceptance. A time-segmented analysis was also desired. Two methods, a new PA questionnaire and accelerometry, were developed during pilot testing. Together, the methods provided qualitative and quantitative information and showed that 3 of 4 sites were able to increase average daily PA, although overall the control versus intervention difference was not significant. The main limitation was inability to distinguish PA among individuals. Accelerometer size and some community concerns led to a protocol based on a single day of wearing time. Newer model triaxial accelerometers that are much smaller and allow sampling of multiple days of activity are recommended for future studies.