Scott B Going
Department Head, Nutritional Sciences
Professor, BIO5 Institute
Professor, Nutritional Sciences
Professor, Physiological Sciences - GIDP
Professor, Physiology
Professor, Public Health
Primary Department
Department Affiliations
(520) 626-3432
Work Summary
Scott Going is an expert in models and methods for assessment of changes in body composition during growth, and with aging, and is currently investigating the effects of chronic exercise versus hormone replacement therapy on bone, soft tissue composition and muscle strength in postmenopausal women, as well as the role of exercise in obesity prevention in children.
Research Interest
Current projects include:The Bone, Estrogen and Strength Training (BEST) study, a randomized prospective study of the effects of hormone replacement therapy on bone mineral density, soft tissue composition, and muscle strength in postmenopausal women (National Institutes of Health). The Profile-based Internet-linked Obesity Treatment study (PILOT), a randomized study of internet support for weight maintenance after weight loss in peri-menopausal women (National Institutes of Health). The Trial of Activity for Adolescent Girls (TAAG) study, a multi-center, school-based activity trial designed to prevent the usual decline in physical activity in adolescent girls (National Institutes of Health). The Adequate Calcium Today (ACT) study, a randomized multi-center study of a behavioral intervention to promote healthy eating, calcium intake and bone development in adolescent girls (United States Department of Agriculture). The Healthy Weight in Adolescents study, a randomized, multi-center study of the effects of a science-based curriculum focused on concepts of energy balance on body weight and composition in adolescent boys and girls (United States Department of Agriculture). The KNEE study, a randomized clinical trial of the effects of resistance exercise on disease progression, pain, and functional capacity in osteoarthritis patients (National Institutes of Health). The STRONG study, a randomized clinical trial of the effects of resistance exercise and Remicaid on disease progression, pain, muscle strength and functional capacity in rheumatoid arthritis patients (Centocor, Inc.). Partners for Healthy Active Children, Campañeros Para Niños Sano y Actives, designed to create and implement research-based physical education and nutrition curricula at YMCA after-school programs and Sunnyside District elementary schools, in alignment with the State o Arizona , Health and Physical Activity standards (Carol M. White Physical Education Program CFDA #84.215F). Longitudinal Changes in Hip Geometry, an observational and experimental cohort study of changes in muscle mass, hip structural parameters and hip bone strength in middle-aged and older women in the Women's Healthy Initiative study (National Institutes of Health).

Publications

Klimentidis, Y. C., Bea, J. W., Lohman, T. G., Hsieh, P. S., Going, S. B., & Chen, Z. (2015). Resistance exercise intervention results in less weight loss among individuals at high genetic risk for obesity. International Journal of Obesity, 39(9), 1371-1375.
BIO5 Collaborators
Zhao Chen, Scott B Going, Yann C Klimentidis
Farr, J. N., Funk, J. L., Chen, Z., Lisse, J. R., Blew, R. M., Lee, V. R., Laudermilk, M., Lohman, T. G., & Going, S. B. (2011). Skeletal Muscle Fat Content Is Inversely Associated With Bone Strength in Young Girls. JOURNAL OF BONE AND MINERAL RESEARCH, 26(9), 2217-2225.
BIO5 Collaborators
Janet L Funk, Scott B Going
Going, S. B., Chen, Z., Alexander, G. E., Mandarino, L. J., Garcia, D. O., Bea, J. W., Raichlen, D. A., & Klimentidis, Y. C. (2017). Genome-wide association study of habitual physical activity in over 277,000 UK Biobank participants indentifies novel variants and genetic correlations with chronotype and obesity related traits. International Journal of Obesity.
BIO5 Collaborators
Zhao Chen, Scott B Going, Yann C Klimentidis
Boyden, T. W., Pamenter, R. W., Going, S. B., Lohman, T. G., Hall, M. C., Houtkooper, L. B., Bunt, J. C., Ritenbaugh, C., & Aickin, M. (1993). Resistance exercise training is associated with decreases in serum low-density lipoprotein cholesterol levels in premenopausal women. Archives of Internal Medicine, 153(1), 97-100.

PMID: 8422204;Abstract:

Background: Aerobic exercise training is associated with reduced serum concentrations of triglycerides, increased concentrations of high-density lipoprotein cholesterol, and minimal changes in serum levels of total cholesterol or low-density lipoprotein cholesterol. There are few data on the effects of resistance exercise on blood lipid levels. Methods: Premenopausal women were randomly assigned to a supervised resistance exercise training program (n=46) or a control group (n=42) for 5 months. Serum was analyzed for levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. Body composition and dietary intake were also measured. Results: The exercise group showed a 0.33±0.03-mmol/L (mean±SE) decrease in total cholesterol level and a 0.36±0.001-mmol/L decrease in low-density lipoprotein cholesterol level that was significantly different from the control group. No significant changes were noted in serum high-density lipoprotein cholesterol or triglyceride levels in either group. Changes in body composition showed no significant correlations with changes in total cholesterol or low-density lipoprotein cholesterol. There were no significant differences in nutrient intake between the groups. Conclusion: In healthy, premenopausal women, with normal baseline lipid profiles, 5 months of resistance exercise training was associated with significant decreases in serum total cholesterol and low-density lipoprotein cholesterol concentrations.

Farr, J. N., Laddu, D. R., Blew, R. M., Lee, V. R., & Going, S. B. (2013). Effects of physical activity and muscle quality on bone development in girls. Medicine and Science in Sports and Exercise, 45(12), 2332-2340.

PMID: 23698240;PMCID: PMC3833884;Abstract:

INTRODUCTION: Poor muscle quality and sedentary behavior are risk factors for metabolic dysfunction in children and adolescents. However, because longitudinal data are scarce, relatively little is known about how changes in muscle quality and physical activity influence bone development. PURPOSE: In a 2-yr longitudinal study, we examined the effects of physical activity and changes in muscle quality on bone parameters in young girls. METHODS: The sample included 248 healthy girls age 9-12 yr at baseline. Peripheral quantitative computed tomography was used to measure calf and thigh muscle density, an indicator of skeletal muscle fat content or muscle quality, as well as bone parameters at diaphyseal and metaphyseal sites of the femur and tibia. Physical activity was assessed using a validated questionnaire specific for youth. RESULTS: After controlling for covariates in multiple regression models, increased calf muscle density was independently associated with greater gains in cortical (β = 0.13, P