Thomas C Doetschman
Professor, BIO5 Institute
Professor, Cancer Biology - GIDP
Professor, Cellular and Molecular Medicine
Professor, Genetics - GIDP
Primary Department
Department Affiliations
(520) 626-4901
Work Summary
I am investigating a human connective tissue disorder in mice. I am also investigating the role of gut bacteria in colon cancer risk in both a mouse model of colon cancer and in humans with colon cancer.
Research Interest
Dr. Thomas Doetschman, PhD, Biochemistry & Biophysics, University of Connecticut, has been involved in cardiovascular research for over a decade through investigations into the cardiovascular roles of the three TGFβ ligands and FGF2 ligand isoforms in genetically engineered mice. These mice have determined that TGFβ2 plays major roles in heart and vascular development and for maintenance of valvular and large vessel integrity in the adult and that both the TGFβ1 and FGF2 are involved in adult heart disease.His work has also demonstrated roles of TGFβ in cancer and immunology. He found that a major function of TGFβ1 is to inhibit autoimmunity and to establish homeostatic balance between immune regulatory and inflammatory cells. He has shown that an imbalance in the latter is critical in the tumor suppressor function of TGFβ in the colon.Dr. Doetschman has also played an important role in the development of the mouse genetic engineering field. He has been responsible for the establishment of 3 mouse genetic engineering facilities, in Cincinnati OH, Singapore and the University of Arizona’s BIO5 Institute. Keywords: "Cancer", "Microbiome", "Mouse Genetic Engineering", "Connective Tissue Disorder"

Publications

Ball, C. L., Daniel, S. G., Besselsen, D. G., Hurwitz, B. L., & Doetschman, T. C. (2017). Functional changes in the gut microbiome contribute to Transforming Growth Factor β-deficient colon cancer. mSystems, 2(5), 1-17.
BIO5 Collaborators
David G Besselsen, Thomas C Doetschman, Bonnie L Hurwitz
Ludwig, D., Stringer, J., Wight, D., Doetschman, T., & Duffy, J. (1996). FLP-mediated site-specific recombination in microinjected murine zygotes. Transgenic Research, 5(6), 385-395.
Yan, J., Mitra, A., Hu, J., Cutrera, J. J., Xia, X., Doetschman, T., Gagea, M., Mishra, L., & Li, S. (2016). Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells. Journal of Hepatology.

Sepsis is an acute systemic inflammatory response to infection associated with high patient mortality (28-40%). We hypothesized that interleukin (IL)-30, a novel cytokine protecting mice against liver injury resulting from inflammation, would generate a protective effect against systemic inflammation and sepsis-induced death.

Doetschman, T., Sholl, A., Chen, H., Gard, C., Hildeman, D., & Bommireddy, R. (2011). Divergent effects of calcineurin Abeta on regulatory and conventional T-cell homeostasis. Clinical Immunology, 138(3), 321-330.
Thomas, R., Belsito, D., Huang, C., Chen, L. L., Ormsby, I., Simmons, W., Cowin, P., Shaw, J., Doetschman, T., & Thorbecke, G. (2001). Appearance of Langerhans cells in the epidermis of Tgfb1(-/-) SCID mice: paracrine and autocrine effects of transforming growth factor-beta 1 and -beta 2(1).. J Invest Dermatol, 117, 1574-1580.