Cellular & Molecular Medicine

Cellular & Molecular Medicine
Assistant Professor, BIO5 Institute, Assistant Professor, Cellular and Molecular Medicine, Assistant Professor, Genetics - GIDP, Assistant Professor, Physiological Sciences - GIDP, Director, iPS Cell Core
Assistant Professor, BIO5 Institute, Assistant Professor, Biomedical Engineering, Assistant Professor, Cellular and Molecular Medicine, Assistant Professor, Clinical Translational Sciences, Assistant Professor, Physiological Sciences - GIDP
Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Cellular and Molecular Medicine, Professor, Genetics - GIDP
I am investigating a human connective tissue disorder in mice. I am also investigating the role of gut bacteria in colon cancer risk in both a mouse model of colon cancer and in humans with colon cancer.
Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Cellular and Molecular Medicine, Professor, Molecular and Cellular Biology, Professor, Physiological Sciences - GIDP, Professor, Physiology
Our research is focused on elucidating the structure and function of titin and nebulin, two large filamentous proteins found in muscle. We use a range of model systems with a major focus on KO and TG mouse models. The techniques that we use range from single molecule mechanics, (immuno) electron microscopy, exon microarray analysis, in vitro motility assays, low angle X-ray diffraction, cell physiology (including calcium imaging), muscle mechanics, and isolated heart physiology.
Co-Director, Sarver Heart Center, Department Head, Cellular and Molecular Medicine, Director, Molecular Cardiovascular Research Program, Professor, BIO5 Institute, Professor, Cellular and Molecular Medicine, Professor, Molecular and Cellular Biology, Vice Dean, Innovation and Development
The research in my laboratory is focused on identifying the components and molecular mechanisms regulating actin architecture in cardiac and skeletal muscle during normal development and disease. Control of actin filament lengths and dynamics is important for cell motility and architecture and is regulated in part by capping proteins that block elongation and depolymerization at both the fast-growing (barbed) and slow-growing (pointed) ends of the filaments.
Associate Professor, BIO5 Institute, Associate Professor, Physiological Sciences - GIDP, Co-Chair, ABBS Program, Professor, Cellular and Molecular Medicine
The long-term goal of research in my lab is to understand the molecular mechanisms of muscle contraction. I am especially interested in how contractile proteins of muscle sarcomeres regulate the force and speed of contraction in the heart. The question is important from both basic science and clinical perspectives because mutations in sarcomere proteins of muscle are a leading cause of hypertrophic cardiomyopathy (HCM), the most common cause of sudden cardiac death in the young and a prevalent cause of heart failure in adults. Myosin binding protein-C (MyBP-C) is a muscle regulatory protein that speeds actomyosin cycling kinetics in response to adrenaline (b-adrenergic stimuli) and is one of the two most commonly affected proteins linked to HCM. Currently, the major research focus in my lab is understanding the mechanisms by which cMyBP-C regulates contractile speed and mechanisms by which mutations in cMyBP-C cause disease.
Investigator, Center for Toxicology, Professor, BIO5 Institute, Professor, Cellular and Molecular Medicine, Professor, Public Health
We are interested in the effects of early life exposures to environmental toxicants on lung growth and development. We determine if the early life exposures leads to adult disease.
Assistant Professor, BIO5 Institute, Assistant Professor, Clinical Translational Sciences, Assistant Professor, Immunobiology, Associate Professor, Cellular and Molecular Medicine, Associate Professor, Medicine
Julie Ledford's research focuses on respiratory disease, and genetic and molecular mechanisms of allergic airway diseases in children.
Associate Professor, Cellular and Molecular Medicine, Associate Professor, BIO5 Institute, Associate Professor, Immunobiology
Co-Program Leader, Cancer Biology Research Program, Professor, BIO5 Institute, Professor, Cellular and Molecular Medicine
Associate Head, Faculty Development, Associate Professor, BIO5 Institute, Associate Professor, Cancer Biology - GIDP, Associate Professor, Cellular and Molecular Medicine, Associate Professor, Molecular and Cellular Biology, Associate Professor, Genetics - GIDP
Assistant Professor, Cellular and Molecular Medicine, Research Fellow, BIO5 Institute
My laboratory aims to identify the genetic and environmental reasons that certain individuals are predisposed to develop complex diseases like heart disease. We use new technologies, experimental, and computational approaches to identify molecular patterns indicative of disease predisposition.
Assistant Professor, BIO5 Institute, Assistant Professor, Cellular and Molecular Medicine
We combine chemical and computer vision approaches to discover how regenerative tissues process environmental information to promote accurate cell fate decisions and prevent uncontrolled cell growth.
Director, Arizona Center for the Biology of Complex Diseases (ABCD), Professor, BIO5 Institute, Professor, Cellular and Molecular Medicine, Professor, Genetics - GIDP, Associate Director, Asthma / Airway Disease Research Center
Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Cellular and Molecular Medicine, Professor, Neuroscience - GIDP, Director, Willed Body Program