Immunobiology

Professor, Immunobiology, Professor, Applied BioSciences - GIDP, Member of the Graduate Faculty, Professor, BIO5 Institute
Professor, Immunobiology, Associate Professor, Surgery, Associate Professor, Genetics - GIDP, Associate Professor, Cancer Biology - GIDP, Member of the Graduate Faculty, Associate Professor, BIO5 Institute
Associate Professor, Immunobiology, Associate Research Scientist, Member of the Graduate Faculty

I am currently appointed as Associate Professor of Immunobiology, and Associate Research Scientist, Asthma and Airway Disease Research Center (A2DRC), College of Medicine, The University of Arizona. My main areas of expertise include immunology and systems biology/genomic data analysis in the context of respiratory disease, allergy, and various modalities of immunotherapy. My research program is underpinned by the concept that genes do not exist nor function in isolation, they function as components of an interconnected system. My lab has performed the first studies to identify allergen-induced and rhinovirus-induced gene network patterns that underpin the pathogenesis of asthma and related traits. The long-term goal of this work is to unlock the basic immune mechanisms and principles that govern the early origins of asthma and identify novel pathways for therapeutic intervention.

 
Professor, Immunobiology , Member of the Graduate Faculty

Cancer models have been utilized to define properties of the anti-tumor response and factors that regulate the function of distinct cellular populations. The overarching results highlight the importance of the Wnt signaling pathways that utilize the canonical pathways but also new pathways that don’t utilize the canonical pathways. These pathways may also be significantly impacted by Notch signaling. Novel cellular functions have been identified and the hope is that it will lead to innovative therapeutic approaches to treat cancer. In addition, studies of the Wnt antagonist DKK1 in the chronic parasitic infections by Leishmania major are being utilized to define the primary mechanistic interactions that lead to the infections.

Associate Professor, Immunobiology, Associate Professor, Molecular and Cellular Biology, Associate Professor, Cancer Biology - GIDP, Associate Professor, BIO5 Institute

We aim to understand the mechanisms of HPV infection, the cellular responses to HPV infection, and how the interplay between host and virus influences the outcome

Associate Professor, Immunobiology, Associate Professor, Neurology, Associate Professor, Neurosurgery, Associate Professor, Psychology, Associate Professor, Neuroscience - GIDP, Member of the Graduate Faculty, Research Scientist, Associate Professor, BIO5 Institute

Approximately 795,000 Americans suffer a stroke each year, and 400,000 will experience long-term disability. The number of stroke survivors in the population is expected to double by 2025. Currently, treatments for stroke patients are limited to tissue plasminogen activator (TPA), but its use is limited to the first few hours after stroke. Therefore, the goal of our research is to develop new therapeutics that can promote repair and recovery in this rapidly growing population.

Interim Associate Department Head, Immunobiology, Member of the Graduate Faculty, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Cellular and Molecular Medicine, Professor, Genetics - GIDP, Professor, Immunobiology, Professor, Molecular and Cellular Biology

Dr. Goodrum's long-standing research focus is to understand the molecular virus-host interactions important to human cytomegalovirus (CMV) latency and persistence in the host. She has focused on identifying viral and host determinants mediating the switch between latent and replicative states. The goal of her research program is to define the mechanistic underpinnings of HCMV latency and reactivation to lay the foundation for clinical interventions to control CMV disease in all settings.

Associate Professor, Applied BioSciences - GIDP, Associate Professor, BIO5 Institute, Associate Professor, Immunobiology, Member of the Graduate Faculty

Metals such as calcium and iron are essential to living organisms. Some metals in excess, like copper, are detrimental to bacteria. My laboratory studies this phenomenon in Streptococcus pneumoniae to find novels method for killing pathogenic bacteria.

Associate Professor, Immunobiology, Associate Professor, Genetics - GIDP, Associate Professor, BIO5 Institute

Michael Kuhns' research program is focused on (i) increasing our basic understanding of how T cell fate decisions are made (e.g. development, activation, differentiation, effector functions), and (ii) increasing their working knowledge of how to manipulate these decisions to direct T cells towards a desired outcome, such as increasing responses to vaccines or tumors, preventing transplant rejection, or attenuating autoimmunity.

Department Head, Immunobiology, Co-Director, Arizona Center on Aging, Professor, Immunobiology, Professor, Medicine, Professor, Nutritional Sciences, Professor, Genetics - GIDP, Professor, Neuroscience - GIDP, Professor, BIO5 Institute
Assistant Professor, Immunobiology, Assistant Professor, Cancer Biology - GIDP, Member of the Graduate Faculty, Research Fellow, BIO5 Institute

All viruses hijack host cell machinery to facilitate their replication. My lab investigates how the production of infectious viral progeny relies on host metabolism. Our overall goal is to guide the development of novel antiviral therapies using information regarding how viruses hijack host metabolism.

Professor, Immunobiology, Director, Microbial Pathogenesis Program, Professor, Animal and Comparative Biomedical Sciences, Professor, Biochemistry/Molecular Biophysics, Professor, Genetics - GIDP, Professor, Molecular and Cellular Biology, Professor, BIO5 Institute

How do bacteria "talk" to the body? How does the body reply to the microbe? How does this conversation affect your health and well being?

Assistant Professor, Immunobiology, Assistant Professor, Cancer Biology - GIDP, Member of the Graduate Faculty, Assistant Professor, BIO5 Institute