In the past 10 years, the nation’s opioid crisis has skyrocketed. Local startup Regulonix has licensed a newly invented class of non-opioid painkillers that are non-addictive and non-toxic at high doses and more effective than morphine. These inhibitors indirectly regulate voltage-gated sodium Nav1.7 channel via a unique pathway. While chronic pain and opioid misuse and overdose are widely prevalent, the discovery could provide viable options to combat these major public health crises. The company's co-founders and inventors include associate professor of anesthesiology and neuroscience and professor of pharmacology Dr. Rajesh Khanna, assistant professor of pharmacology Dr. May Khanna, and senior research scientist Dr. Vijay Gokhale.