Biochemistry
Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Chemistry and Biochemistry-Sci
Assistant Professor, BIO5 Institute, Assistant Professor, Molecular and Cellular Biology
Research Professor, Research Professor, BIO5 Institute
Peptides and proteins play a vital role in almost every cellular process in living organisms. Our research discovers and determines structural information on peptides and proteins to design drugs to more effectively treat human disease.
Associate Professor, BIO5 Institute, Associate Professor, Chemistry and Biochemistry-Sci
Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Cellular and Molecular Medicine, Professor, Genetics - GIDP
I am investigating a human connective tissue disorder in mice. I am also investigating the role of gut bacteria in colon cancer risk in both a mouse model of colon cancer and in humans with colon cancer.
Professor, BIO5 Institute, Professor, Chemistry and Biochemistry-Sci
The broad objective of our research program in Bioorganic Chemistry and Chemical Biology is to construct protein therapeutics, protein mimetics, biomaterials, and biosensors. Our research at the University of Arizona is highly multidisciplinary and utilizes techniques in organic synthesis, biochemistry, molecular biology, and a host of physical characterization methods. Our research motto is simple: Unraveling mysteries and Enabling discoveries.
Associate Professor, BIO5 Institute, Associate Professor, Physiological Sciences - GIDP, Co-Chair, ABBS Program, Professor, Cellular and Molecular Medicine
The long-term goal of research in my lab is to understand the molecular mechanisms of muscle contraction. I am especially interested in how contractile proteins of muscle sarcomeres regulate the force and speed of contraction in the heart. The question is important from both basic science and clinical perspectives because mutations in sarcomere proteins of muscle are a leading cause of hypertrophic cardiomyopathy (HCM), the most common cause of sudden cardiac death in the young and a prevalent cause of heart failure in adults. Myosin binding protein-C (MyBP-C) is a muscle regulatory protein that speeds actomyosin cycling kinetics in response to adrenaline (b-adrenergic stimuli) and is one of the two most commonly affected proteins linked to HCM. Currently, the major research focus in my lab is understanding the mechanisms by which cMyBP-C regulates contractile speed and mechanisms by which mutations in cMyBP-C cause disease.
Assistant Professor, BIO5 Institute, Assistant Professor, Chemistry and Biochemistry
Andrew Hausrath's lab studies the structures of proteins and complexes using X-ray crystallography, microscopy, and biophysical techniques. Proteins of certain classes are heavily represented as components of complexes. Knowledge of the structures and properties of the proteins which function within higher-order complexes then stimulates development of improved models and theory about how such complexes carry out their functions in the cell. Systems of current interest include the ATP synthase, the signaling hormone adiponectin, and the higher-order organization of chromatin in the nucleus.
Regents Professor Emeritus, Professor Emeritus
Our research is centered on the prevention and treatment of our major degenerative diseases. We concentrate on peptide hormones and neurotransmitters and their receptors that are involved in these major diseases. Specific potential applications include pigmentary disorders, melanoma cancer, feeding disorders, pain, sexual function and motivation, and neurodegenerative diseases such as Alzheimer's, Parkinson's, etc.
Associate Director, BIO5 Institute, Professor, BIO5 Institute, Professor, Medicinal Chemistry-Pharmaceutical Sciences, Professor, Medicinal Chemistry-Pharmacology and Toxicology, Professor, Cancer Biology - GIDP
Laurence Hurley's long-time research interest is in molecular targeting of DNA, first by covalent binders (CC-1065 and psorospermin), then as compounds that target protein–DNA complexes (pluramycins and Et 743), and most recently as four-stranded DNA structures (G-quadruplexes and i-motifs). He was the first to show that targeting G-quadruplexes could inhibit telomerase (Sun et al. [1997] J. Med. Chem., 40, 2113) and that targeting G-quadruplexes in promoter complexes results in inhibition of transcription (Siddiqui-Jain et al. [2002] Proc. Natl. Acad. Sci. U.S.A., 99, 11593).
Professor, BIO5 Institute, Professor, Entomology, Professor, Entomology / Insect Science - GIDP
Xianchun Li's research aims to use genetics to shed light on the defense signaling of plants and the counterdefense of herbivorous insects, which may result in the design of new insecticides for crops like corn, in defense against the corn earworm. Additionally, Dr. Li's research is to define, globally, the regulatory triangle between nuclear receptors (NRs), their ligands, and cytochrome P450s (P450s) in Drosophila melanogaster, and to investigate the molecular mechanisms of Bt and conventional insecticide resistance.
Chair, Institutional Animal Care-USE Committee, Director, Agriculture Research Complex, Professor, Animal and Comparative Biomedical Sciences, Professor, BIO5 Institute, Professor, Obstetrics and Gynecology, Professor, Physiological Sciences - GIDP
Our current research program use an integrative approach at the whole animal, isolated organ, cellular and molecular levels to investigate developmental adaptations in pancreatic β-cells and insulin sensitivity that result from early life risk factors, such as intrauterine growth restriction, and increase risk of glucose intolerance and Diabetes in later life.
Associate Director, Shared Resources, Associate Professor, Pharmacology, Director, Aribi Institute, Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Physiological Sciences - GIDP, Professor, Physiology
Precise diagnosis and treatment of disease requires an ability to target agents to specific tissues and cell types within those tissues. We are developing agents that exhibit cell type specificity for these purposes.
Professor, BIO5 Institute, Professor, Chemistry and Biochemistry-Sci
Associate Professor, BIO5 Institute, Associate Professor, Chemistry and Biochemistry-Sci
We seek to produce new drugs that harness molecules produced during the natural immune response in order to treat cancer and pain. Such compounds may also provide new treatments for heart failure and alcoholism.
Professor, Applied Mathematics - GIDP, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Genetics - GIDP, Professor, Molecular and Cellular Biology, Professor, Chemistry and Biochemistry-Sci
We investigate how proteins work in healthy organisms and how they fail in disease. We determine the atomic structures of proteins and the underlying biochemistry that gives rise to protein function. We also develop new proteins as drug targets for treating cancer and cardiovascular disease.
Professor, BIO5 Institute, Professor, Chemistry and Biochemistry, Professor, Chemistry and Biochemistry-Sci, Professor, Immunobiology
How we sense and react to our environment is communicated in the cell by vast networks of highly dynamic, interacting proteins. These interactions are regulated in both space and time, and it is this tight regulation that allows signals from outside of the cell to be rapidly and precisely transmitted to the nucleus leading to the appropriate, and healthy, cellular response. My research integrates structural biology, biophysics and biochemistry in order to understand how these signals and to develop novel drugs for the treatment of cancer, autoimmune disorders and antibiotic resistance.
Professor, Chemistry and Biochemistry, Professor, BIO5 Institute, Professor, Chemistry and Biochemistry-Sci
Assistant Professor, BIO5 Institute, Assistant Professor, Chemistry and Biochemistry - Med, Assistant Professor, Chemistry and Biochemistry-Sci, Assistant Professor, Neuroscience - GIDP
Associate Professor, BIO5 Institute, Associate Professor, Pharmacology and Toxicology, Associate, Center for Toxicology, Co-Director, Bachelor of Science - Pharmaceutical Sciences Program
Professor, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP