Chemistry
Professor, Applied Mathematics - GIDP, Professor, BIO5 Institute, Professor, Chemistry and Biochemistry-Sci
Adjunct Professor, Mining and Geological Engineering, Associate Dean, Research-Public Health, Professor, BIO5 Institute, Professor, Public Health, Associate Dean, Research - Mel and Enid Zuckerman College of Public Health
Assistant Professor, BIO5 Institute, Assistant Professor, Soil / Subsurface Microbial Ecology
We investigate the myriad of ways microbes living in the wild (soil, water and air) affect Earth processes and our health.
Associate Professor, BIO5 Institute, Associate Professor, Materials Science and Engineering, Distinguished Scholar, Materials Science and Engineering, Associate Professor, Aerospace-Mechanical Engineering
Associate Professor, BIO5 Institute, Professor, Environmental Science-Ext
Clinical Instructor, Pharmacy Practice-Science, Professor, Medicine, Professor, BIO5 Institute, Professor, Nutritional Sciences
Janet Funk's work includes a focus on metastatic breast cancer that spans the research spectrum from bench to bedside, translational arthritis studies of the pharmacokinetics and safety of turmeric, and collaborative endocrinological studies evaluating the effects of obesity and insulin resistance on bone development in Hispanic girls, as well as effects of metformin on breast cancer risk on obese women.
Research Professor, Center for Toxicology, Research Professor, BIO5 Institute
Dr. Gandolfi directed toxicology research projects at the University of Arizona since 1978. His research interests are in the toxicity of halogenated hydrocarbons and metals with an emphasis on hepatic and renal systems. He was also active in developing in vitro toxicity models and the disposition of xenobiotics.
Professor, BIO5 Institute, Professor, Chemistry and Biochemistry-Sci
The broad objective of our research program in Bioorganic Chemistry and Chemical Biology is to construct protein therapeutics, protein mimetics, biomaterials, and biosensors. Our research at the University of Arizona is highly multidisciplinary and utilizes techniques in organic synthesis, biochemistry, molecular biology, and a host of physical characterization methods. Our research motto is simple: Unraveling mysteries and Enabling discoveries.
Senior Research Scientist, BIO5 Institute
Vijay Gokhale's work includes the use of medicinal chemistry in the development of small molecule therapeutics for neuropathic pain, idiopathic pulmonary fibrosis (IPF), and acute lung injury and cancer.
Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Cellular and Molecular Medicine, Professor, Molecular and Cellular Biology, Professor, Physiological Sciences - GIDP, Professor, Physiology
Our research is focused on elucidating the structure and function of titin and nebulin, two large filamentous proteins found in muscle. We use a range of model systems with a major focus on KO and TG mouse models. The techniques that we use range from single molecule mechanics, (immuno) electron microscopy, exon microarray analysis, in vitro motility assays, low angle X-ray diffraction, cell physiology (including calcium imaging), muscle mechanics, and isolated heart physiology.
Director, Natural Products Center, Professor, Arid Lands Resources Sciences - GIDP, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Natural Resources and the Environment, Professor, Pharmacology and Toxicology
Discovery of natural products from plants and their associated microorganisms as potential drugs to treat cancer. Application of medicinal chemistry approach for structure-activity relationship studies and to obtain compounds for preclinical evaluation. Development of alternative agricultural systems for sustainable utilization of natural resources.
Assistant Professor, BIO5 Institute, Assistant Professor, Optical Sciences, Assistant Professor, Physics
Regents Professor Emeritus, Professor Emeritus
Our research is centered on the prevention and treatment of our major degenerative diseases. We concentrate on peptide hormones and neurotransmitters and their receptors that are involved in these major diseases. Specific potential applications include pigmentary disorders, melanoma cancer, feeding disorders, pain, sexual function and motivation, and neurodegenerative diseases such as Alzheimer's, Parkinson's, etc.
Associate Director, BIO5 Institute, Professor, BIO5 Institute, Professor, Medicinal Chemistry-Pharmaceutical Sciences, Professor, Medicinal Chemistry-Pharmacology and Toxicology, Professor, Cancer Biology - GIDP
Laurence Hurley's long-time research interest is in molecular targeting of DNA, first by covalent binders (CC-1065 and psorospermin), then as compounds that target protein–DNA complexes (pluramycins and Et 743), and most recently as four-stranded DNA structures (G-quadruplexes and i-motifs). He was the first to show that targeting G-quadruplexes could inhibit telomerase (Sun et al. [1997] J. Med. Chem., 40, 2113) and that targeting G-quadruplexes in promoter complexes results in inhibition of transcription (Siddiqui-Jain et al. [2002] Proc. Natl. Acad. Sci. U.S.A., 99, 11593).
Assistant Professor, BIO5 Institute, Assistant Professor, Biomedical Engineering, Assistant Professor, Optical Sciences
We are developing low-cost in vivo microscopy devices that can visualize cellular details of human tissues in vivo and help disease diagnosis and treatment in low-resource settings, high-speed tissue microscopy technologies that can examine entire organ under risk of having malignant diseases and detect small, early-stage lesions, and miniature microscopy devices that have the potential to examine anatomically-challenging human organs and facilitate integration of microscopic imaging with other imaging modalities.
Adjunct Associate Professor, Nursing, Assistant Professor, Medicine - (Research Scholar Track), Associate Professor, BIO5 Institute, Associate Professor, Genetics - GIDP, Associate Professor, Pharmacology and Toxicology, Associate Professor, Public Health, Interim Associate Dean, Academic Programs and Faculty Affairs
Walter Klimecki's research program involves the balance between the particular DNA sequence “versions” of genes that we inherit from our ancestors, and the particular environmental exposures that we experience throughout our lives. The Klimecki lab studies diseases resulting from human exposure to arsenic, contributing to a better understanding of the inherited genetic differences between people that result in altered chemical processing of arsenic after it enters the body.
Professor, Electrical and Computer Engineering, Professor, Optical Sciences
Raymond Kostuk's research is focused on Optical imaging and systems, photovoltaic devices and systems, holography, electro-optics, and fiber optic systems
Investigator, Center for Toxicology, Professor, BIO5 Institute, Professor, Cellular and Molecular Medicine, Professor, Public Health
We are interested in the effects of early life exposures to environmental toxicants on lung growth and development. We determine if the early life exposures leads to adult disease.
Professor, BIO5 Institute, Professor, Chemistry and Biochemistry, Professor, Materials Science and Engineering
Developing safer, more stable sunscreens
Associate Director, Shared Resources, Associate Professor, Pharmacology, Director, Aribi Institute, Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Physiological Sciences - GIDP, Professor, Physiology
Precise diagnosis and treatment of disease requires an ability to target agents to specific tissues and cell types within those tissues. We are developing agents that exhibit cell type specificity for these purposes.
Adjunct Professor, Pharmacology and Toxicology
Professor, BIO5 Institute, Professor, Chemistry and Biochemistry-Sci
Associate Professor, BIO5 Institute, Associate Professor, Chemistry and Biochemistry-Sci
We seek to produce new drugs that harness molecules produced during the natural immune response in order to treat cancer and pain. Such compounds may also provide new treatments for heart failure and alcoholism.
Professor, Applied Mathematics - GIDP, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Genetics - GIDP, Professor, Molecular and Cellular Biology, Professor, Chemistry and Biochemistry-Sci
We investigate how proteins work in healthy organisms and how they fail in disease. We determine the atomic structures of proteins and the underlying biochemistry that gives rise to protein function. We also develop new proteins as drug targets for treating cancer and cardiovascular disease.
Department Chair, Chemical and Environmental Engineering, Professor, BIO5 Institute, Professor, Chemical and Environmental Engineering
Research Professor
Professor, BIO5 Institute, Regents Professor, Professor, Chemistry and Biochemistry-Sci
Professor, Chemistry and Biochemistry, Professor, BIO5 Institute, Professor, Chemistry and Biochemistry-Sci
Professor, BIO5 Institute, Professor, Chemistry and Biochemistry-Sci, Professor, Neuroscience - GIDP, Professor, Pharmacology and Toxicology
Professor, BIO5 Institute, Professor, Chemistry and Biochemistry-Sci
Assistant Professor, BIO5 Institute, Assistant Professor, Chemical and Environmental Engineering, Assistant Professor, Materials Science and Engineering
Associate, Center for Toxicology, Professor, Animal and Comparative Biomedical Sciences, Professor, BIO5 Institute, Professor, Nutritional Sciences, Professor, Cancer Biology - GIDP
Professor, Applied Mathematics - GIDP, Professor, BIO5 Institute, Regents Professor
Assistant Professor, BIO5 Institute, Assistant Professor, Chemistry and Biochemistry
Assistant Research Scientist, BIO5 Institute, Staff Scientist
Director, Ligand Discovery Laboratory, Research Associate Professor, Pharmacology, Research Professor
Co-Director, MD/PhD Dual Degree Program, Department Head, Pharmacology, Professor, Anesthesiology, Professor, BIO5 Institute, Professor, Neurology, Professor, Neuroscience - GIDP, Professor, Pharmacology, Professor, Physiological Sciences - GIDP
Associate Professor, BIO5 Institute, Associate Professor, Molecular and Cellular Biology, Associate Professor, Optical Sciences, Associate Professor, Physics, Associate Professor, Applied Mathematics - GIDP
Director, Drug Discovery Program, Professor, Pharmacology and Toxicology
Investigator, Center for Toxicology, Professor, BIO5 Institute, Professor, Biochemistry/Molecular Biophysics, Professor, Physiological Sciences - GIDP, Professor, Physiology
The kidney plays a critical role in clearing the body of potentially harmful compounds, including many commonly prescribed drugs. Unfortunately, this also sets the kidney up as a site where multiple drugs can interact in unwanted ways. We study the cellular transport processes responsible for renal drug clearance with the intent of developing predictive models that can assist clinicians, drug companies, and the Food & Drug Administration in their efforts to increase patient safety.