Associate Director, Omics, Research Scientist, Arizona Research Labs, Research Scientist, BIO5 Institute, Research Scientist, Ecology and Evolutionary Biology, Research Scientist, Neurology

Michael Hammer has headed a productive research lab in human evolutionary genetics. His lab were early adopters of next generation sequencing (NGS) technology successfully employed NGS methods to identify molecular lesions causing neurodevelopmental disorders in undiagnosed children. His lab is also currently pursuing studies to identify modifier genes that alter the expression of major genes and how they contribute to phenotypic heterogeneity in Mendelian disorders.

Associate Professor, Chemistry and Biochemistry - Med, Associate Professor, Chemistry and Biochemistry-Sci, Associate Professor, Genetics - GIDP, Associate Professor, Molecular and Cellular Biology
The Horton lab uses biophysical, biochemical, and molecular biology to study protein-DNA interactions and filament formation by enzymes. Current projects include the investigation of mechanisms of disease caused by the Human Parvovirus B19, and advantages of filament formation by enzymes such as the sequence specific DNA endonuclease SgrAI, and the important metabolic enzyme PFK.
Associate Director, BIO5 Institute, Professor, BIO5 Institute, Professor, Medicinal Chemistry-Pharmaceutical Sciences, Professor, Medicinal Chemistry-Pharmacology and Toxicology, Professor, Cancer Biology - GIDP
Laurence Hurley's long-time research interest is in molecular targeting of DNA, first by covalent binders (CC-1065 and psorospermin), then as compounds that target protein–DNA complexes (pluramycins and Et 743), and most recently as four-stranded DNA structures (G-quadruplexes and i-motifs). He was the first to show that targeting G-quadruplexes could inhibit telomerase (Sun et al. [1997] J. Med. Chem., 40, 2113) and that targeting G-quadruplexes in promoter complexes results in inhibition of transcription (Siddiqui-Jain et al. [2002] Proc. Natl. Acad. Sci. U.S.A., 99, 11593).
Adjunct Associate Professor, Nursing, Assistant Professor, Medicine - (Research Scholar Track), Associate Professor, BIO5 Institute, Associate Professor, Genetics - GIDP, Associate Professor, Pharmacology and Toxicology, Associate Professor, Public Health, Interim Associate Dean, Academic Programs and Faculty Affairs
Walter Klimecki's research program involves the balance between the particular DNA sequence “versions” of genes that we inherit from our ancestors, and the particular environmental exposures that we experience throughout our lives. The Klimecki lab studies diseases resulting from human exposure to arsenic, contributing to a better understanding of the inherited genetic differences between people that result in altered chemical processing of arsenic after it enters the body.
Coordinator, Bac/Est Resource Center
We are a plant genomics lab who specialize in whole genome sequencing and assembly; with analyses of structural variation, gene modeling and transcriptomes. Our work on major projects of rice, corn, barley, etc, allows us to share our technical expertise with other researchers.
Assistant Professor, Cellular and Molecular Medicine, Research Fellow, BIO5 Institute
My laboratory aims to identify the genetic and environmental reasons that certain individuals are predisposed to develop complex diseases like heart disease. We use new technologies, experimental, and computational approaches to identify molecular patterns indicative of disease predisposition.
Bud Antle Endowed Chair For Excellence, Agriculture-Life Sciences, Director, Plant Genomics Institute, Professor, BIO5 Institute, Professor, Ecology and Evolutionary Biology, Professor, Plant Science, Regents Professor
Harnessing 15MY of natural variation in the genus Oryza (rice) to help solve the 10-billion people question: i.e. how do we feed our world without destroying our world.
Professor, BIO5 Institute, Professor, Pharmacology and Toxicology, Professor, Cancer Biology - GIDP