Professor, BIO5 Institute, Professor, Entomology / Insect Science - GIDP, Professor, Plant Science, Regents Professor, Plant Sciences, Research Associate Professor, Entomology
Unravel the phylodynamics and transmission-specific determinants of emerging plant virus/fastidious bacteria-insect vector complexes, and translate new knowledge to abate pathogen spread in food systems.
Director, Valley Fever Center for Excellence, Member of the Graduate Faculty, Professor, BIO5 Institute, Professor, Immunobiology, Professor, Internal Medicine, Professor, Medicine
Valley Fever (coccidioidomycosis) occurs more in Arizona than anywhere else. My research and others at the Valley Fever Center for Excellence involve understanding how disease is caused by infection, how the immune system stops or prevents illness, and how we can better diagnose, treat, or prevent this public health problem.
Associate Professor, BIO5 Institute, Associate Professor, Chemistry and Biochemistry-Sci, Member of the Graduate Faculty
We seek to develop tools and strategies to expedite the understanding and treatment of the dengue virus. These advances will be transferable to other areas of virology and biochemistry. Along these lines, we are engaged in three core synergistic projects to answer the following questions: (1) Do unnatural metabolites incorporated into DENV serve as reporters for host-pathogen interactions? (2) What are the host-pathogen interactions in DENV that are targetable for diagnosis or treatment? (3) Is there a chemical reaction between two small molecules that reports on the interaction between DENV and host proteins?
Associate Professor, Associate Professor, BIO5 Institute, Associate Professor, Evelyn F Mcknight Brain Institute, Associate Professor, Immunobiology, Associate Professor, Medicine, Associate Professor, Neuroscience - GIDP
We study how a common intracellular parasite, Toxoplasma gondii, persists in, and potentially changes, the mammalian brain. Understanding the Toxoplasma-brain interaction offers the opportunity to develop better therapies to treat toxoplasmosis as well as giving new insights into how to manipulate the brain immune response which has been implicated in many neurodegenerative diseases.
Distinguished Professor, Chemistry and Biochemistry, Professor, BIO5 Institute, Professor, Chemistry and Biochemistry, Professor, Entomology / Insect Science - GIDP, Professor, Molecular and Cellular Biology
Co-Director, Collaboratory for Anti-infectives & Therapeutics, Professor, Animal and Comparative Biomedical Sciences, Professor, BIO5 Institute, Professor, Immunobiology
Our research efforts focus on bacteria that cause serious healthcare-associated infections, and those associated with antibiotic use. This infections disproportiOur federally-funded research focuses on infection prevention. Specifically, we study diseases such as Clostridium difficile Infection that affect populations worldwide ("One-Health" issue). Our current efforts are aimed at translating bench-research findings to the bedside. We have recently been awarded two patents for a novel biologic agent invention aimed at preventing bacterial infections in humans as well as food animals.onately affect the elderly, and those with compromised immune systems. One overarching goal of our studies is to develop safe, cost-effective, non-antibiotic interventions to prevent and treat bacterial diarrheas.