Metastasis

Ian F Robey

Research Scholar
Primary Department
Contact
(520) 626-5874

Research Interest

Ian Robey, PhD, is a Research Assistant Professor with the Department of Medicine, University of Arizona, and a Full Investigator at the Arizona Cancer Center. Dr. Robey is a new investigator studying the role of pH in tumor behavior. He is interested in the mechanisms driving acid-mediated invasion and metastases and how pH modulation can be used for therapeutic purposes in cancer treatment.Dr. Robey is published in over 20 research articles ranging in immunology and cancer biology. He regularly presents his research at national meetings and conferences. He is a lecturer for the introductory biology course for Biomedical Engineering and serves as a committee member for graduate student comprehensive examinations. He is a mentor for Molecular and Cellular Biology student projects. He has been a regular attending and voting IRB member since 2008. He is a regular peer reviewer of grant proposals and manuscripts. Dr. Robey’s current research is focused on investigating the mechanisms of systemic alkalinization in tumor bearing mice to inhibit the spread of metastases. The objective of my project is to advance the preclinical findings on the effects of tumor alkalinization to promote the application of eventual clinical trials with the expectation of establishing a research program bridging integrative medicine and diagnosis/ therapy driven non-invasive imaging methodologies.

Cynthia Miranti

Professor, Cellular and Molecular Medicine
Chair, Cancer Biology - GIDP
Co-Program Leader, Cancer Biology Research Program
Member of the Graduate Faculty
Professor, BIO5 Institute
Primary Department
Contact
(520) 626-2269

Research Interest

Research Interests Our objective is to define how integrin interactions within the tumor microenvironment impact prostate cancer development, hormonal resistance, and metastasis. Our approach is to understand the normal biology of the prostate gland and its microenvironment, as well as the bone environment, to inform on the mechanisms by which tumor cells remodel and use that environment to develop, acquire hormonal resistance, and metastasize. Our research is focused in three primary areas: 1) developing in vitro and in vivo models that recapitulate human disease based on clinical pathology, 2) identifying signal transduction pathway components that could serve as both clinical markers and therapeutic targets, and 3) defining the genetic/epigenetic programming involved in prostate cancer development.