Associate Department Head, Environmental Science, Member of the Graduate Faculty, Professor, BIO5 Institute, Professor, Environmental Science
Assistant Professor, BIO5 Institute, Assistant Professor, Genetics - GIDP, Assistant Professor, Pharmacology and Toxicology, Member of the Graduate Faculty
Professor, BIO5 Institute, Professor, Chemistry and Biochemistry-Sci
The broad objective of our research program in Bioorganic Chemistry and Chemical Biology is to construct protein therapeutics, protein mimetics, biomaterials, and biosensors. Our research at the University of Arizona is highly multidisciplinary and utilizes techniques in organic synthesis, biochemistry, molecular biology, and a host of physical characterization methods. Our research motto is simple: Unraveling mysteries and Enabling discoveries.
Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Cellular and Molecular Medicine, Professor, Genetics - GIDP, Professor, Molecular and Cellular Biology, Professor, Physiological Sciences - GIDP, Professor, Physiology
Our research is focused on elucidating the structure and function of titin and nebulin, two large filamentous proteins found in muscle. We use a range of model systems with a major focus on KO and TG mouse models. The techniques that we use range from single molecule mechanics, (immuno) electron microscopy, exon microarray analysis, in vitro motility assays, low angle X-ray diffraction, cell physiology (including calcium imaging), muscle mechanics, and isolated heart physiology.
Co-Director, Sarver Heart Center, Department Head, Cellular and Molecular Medicine, Director, Molecular Cardiovascular Research Program, Professor, BIO5 Institute, Professor, Cellular and Molecular Medicine, Professor, Molecular and Cellular Biology
The research in my laboratory is focused on identifying the components and molecular mechanisms regulating actin architecture in cardiac and skeletal muscle during normal development and disease. Control of actin filament lengths and dynamics is important for cell motility and architecture and is regulated in part by capping proteins that block elongation and depolymerization at both the fast-growing (barbed) and slow-growing (pointed) ends of the filaments.
Member of the Graduate Faculty, Professor, Professor, BIO5 Institute, Professor, Chemistry and Biochemistry - Med, Professor, Chemistry and Biochemistry-Sci, Professor, Genetics - GIDP
The Horton lab uses biophysical, biochemical, and molecular biology to study protein-DNA interactions and filament formation by enzymes. Current projects include the investigation of mechanisms of disease caused by the Human Parvovirus B19, and advantages of filament formation by enzymes such as the sequence specific DNA endonuclease SgrAI, and the important metabolic enzyme PFK.
Professor, BIO5 Institute, Professor, Entomology, Professor, Entomology / Insect Science - GIDP
Xianchun Li's research aims to use genetics to shed light on the defense signaling of plants and the counterdefense of herbivorous insects, which may result in the design of new insecticides for crops like corn, in defense against the corn earworm. Additionally, Dr. Li's research is to define, globally, the regulatory triangle between nuclear receptors (NRs), their ligands, and cytochrome P450s (P450s) in Drosophila melanogaster, and to investigate the molecular mechanisms of Bt and conventional insecticide resistance.
Professor, Applied Mathematics - GIDP, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Genetics - GIDP, Professor, Molecular and Cellular Biology, Professor, Chemistry and Biochemistry-Sci
We investigate how proteins work in healthy organisms and how they fail in disease. We determine the atomic structures of proteins and the underlying biochemistry that gives rise to protein function. We also develop new proteins as drug targets for treating cancer and cardiovascular disease.