Professor, BIO5 Institute, Professor, Plant Science, Research Associate Professor, Entomology, Professor, Entomology / Insect Science - GIDP
Unravel the phylodynamics and transmission-specific determinants of emerging plant virus/fastidious bacteria-insect vector complexes, and translate new knowledge to abate pathogen spread in food systems.
Professor, BIO5 Institute, Professor, Genetics - GIDP, Professor, Immunobiology, Professor, Plant Sciences, Professor, Applied BioSciences - GIDP
Upon infection, viruses must transport their genomes into cells and produce progeny, often under a strict time deadline. We study how the viral proteins interact with with each other and with host cell proteins to efficiently accomplish these processes.
Director, Graduate Program in Immunobiology, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Cellular and Molecular Medicine, Professor, Genetics - GIDP, Professor, Immunobiology, Professor, Molecular and Cellular Biology
Dr. Goodrum's long-standing research focus is to understand the molecular virus-host interactions important to human cytomegalovirus (CMV) latency and persistence in the host. Her recent work has defined the epidermal growth factor receptor (EGFR) as primary pathway targeted by these viral determinants to switch between latent and replicative states of infection. The goal of their research program is to define the mechanistic underpinnings of HCMV latency and lay the foundation for clinical interventions to control CMV disease in all settings.
Associate Professor, BIO5 Institute, Associate Professor, Chemistry and Biochemistry-Sci
We seek to develop tools and strategies to expedite the understanding and treatment of the dengue virus. These advances will be transferable to other areas of virology and biochemistry. Along these lines, we are engaged in three core synergistic projects to answer the following questions: (1) Do unnatural metabolites incorporated into DENV serve as reporters for host-pathogen interactions? (2) What are the host-pathogen interactions in DENV that are targetable for diagnosis or treatment? (3) Is there a chemical reaction between two small molecules that reports on the interaction between DENV and host proteins?
Assistant Professor, Immunobiology, Research Fellow, BIO5 Institute
All viruses hijack host cell machinery to facilitate their replication. My lab investigates how the production of infectious viral progeny relies on host metabolism. Our overall goal is to guide the development of novel antiviral therapies using information regarding how viruses hijack host metabolism.