Hulme, C., & Maggiora, G. M. (2008). Molecular diversity: from small to large, emerging to enabling. Current Opinion in Chemical Biology, 12(3), 257-259.
Hulme, C., Foley, C., & Shaw, A. (2016). Two step route to diverse N-functionalized peptidomimetic-like Isatins through an oxidation/intramolecular oxidative-amidation cascade of Ugi-azide and Ugi-3CR reaction products.. Organic Letters, 18, 4904-4907.
Hulme, C., Morrissette, M. M., Volz, F. A., & Burns, C. J. (1998). The solution phase synthesis of diketopiperazine libraries via the Ugi reaction: Novel application of Armstrong's convertible isonitrile.. Tetrahedron Letters, 39(10), 1113-1116.
Abstract:
This communication describes the generation of high-yielding solution phase diketopiperazine libraries via a '3-step, 1-pot' procedure, employing the Ugi multi-component reaction (MCR), followed by BOC deprotection and cyclization to diketopiperazine (DKP). Exploitation of Armstrong's convertible isonitrile in the Ugi reaction utilising an 'internal nucleophile' approach for diketopiperazine formation is presented.
Hulme, C., Shaw, A. Y., Denning, C. R., & Hulme, C. -. (2012). Selenium dioxide-mediated synthesis of α-ketoamides from arylglyoxals and secondary amines. Tetrahedron letters, 53(32).
A facile and expeditious synthetic approach to α-ketoamides 3 is described. A series of α-ketoamides 3 was synthesized via reaction of selenium dioxide-mediated oxidative amidation between arylglyoxals 1 and secondary amines 2, and accelerated with microwave irradiation. Our findings indicate that constrained amines, such as piperazine and piperidine exhibit higher conversions for this transformation. This reaction was explored by synthesizing a series of α-ketoamides 3 from various arylglyoxals with cyclic and acyclic secondary amines.
Hsu, M., Dietrich, J., Hulme, C., & Shaw, A. Y. (2013). Synthesis of di- and tri-substituted imidazole-4-carboxylates via PBu3-mediated [3+2] cycloaddition. Synthetic Communications, 43(11), 1538-1542.
Abstract:
Some new di- and trisubstituted imidazole-4-carboxylates were prepared from amidoacetic acids 3 in the present report. The key step to establish such imidazole- 4-carboxylates stemmed from the PBu3-mediated [3+2] cycloaddition between in situ-generated Δ2-oxazolinone 4 and ethyl cyanoformate6. Our results indicated that trisubstituted imidazoles 7-20 were afforded in better yields than those of disubstituted imidazoles 21-27. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications1 to view the free supplemental file. Copyright © Taylor & Francis Group, LLC.