John JB Allen

John JB Allen

Professor, Psychology
Distinguished Professor
Professor, BIO5 Institute
Member of the General Faculty
Professor, Neuroscience - GIDP
Member of the General Faculty
Member of the Graduate Faculty
Primary Department
Department Affiliations
Contact
(520) 621-7448

Work Summary

Depression is a major health problem that is often chronic or recurrent. Existing treatments have limited effectiveness, and are provided wihtout a clear indication that they will match a particular patient's needs. In this era of precision medicine, we strive to develop neurally-informed treatments for depression and related disorders.

Research Interest

Dr. Allen’s research spans several areas, but the main focus is the etiology and treatment of mood and anxiety disorders. His work focuses on identifying risk factors for depression using electroencephalographic and autonomic psychophysiological measures, especially EEG asymmetry, resting state fMRI connectivity, and cardiac vagal control. Based on these findings, he is developing novel and neurally-informed treatments for mood and anxiety disorders, including Transcranial Ultrasound, EEG biofeedback, and Transcranial Direct Current and Transcranial Alternating Current stimulation. Other work includes understanding how emotion and emotional disorders influence the way we make decisions and monitor our actions. Keywords: Depression, Neuromodulation, EEG, Resting-state fMRI

Publications

Movius, H. L., & Allen, J. J. (2005). Cardiac Vagal Tone, defensiveness, and motivational style. Biological Psychology, 68(2), 147-162.

PMID: 15450694;Abstract:

Cardiac Vagal Tone has been proposed as a stable biological marker for the ability to sustain attention and regulate emotion [Porges, Monographs of the Society for Research in Child Development 59 (1994) 167-186]. Vagal tone is a physiological index of parasympathetic nervous system influence on the heart that has predicted a number of emotional behaviors and styles in infants, children, and adults. Little research, however, has sought to explore the link between vagal tone and established variables relating to personality and self-regulation. In this study, vagal tone was collected during 5-min baseline, stress, and recovery periods. Subjects (n=98) also completed a short form of the Marlowe-Crowne Social Desirability Scale, the Behavioral Activation and Behavioral Inhibition Scales, the Taylor Manifest Anxiety Scale, the Self-Consciousness Scale, and the Openness to Experience subscale of the Five Factor Personality Inventory. Poorer modulation for vagal tone was associated with greater social anxiety, while lower vagal tone across recording periods was associated with greater defensiveness and lower behavioral activation sensitivity. © 2004 Elsevier B.V. All rights reserved.

Allen, J., Mertens, R., & Allen, J. J. (2008). The role of psychophysiology in forensic assessments: deception detection, ERPs, and virtual reality mock crime scenarios. Psychophysiology, 45(2).

Few data are available to address whether the use of ERP-based deception detection alternatives have sufficient validity for applied use. The present study was designed to replicate and extend J. P. Rosenfeld, M. Soskins, G. Bosh, and A. Ryan's (2004) study by utilizing a virtual reality crime scenario to determine whether ERP-based procedures, including brain fingerprinting, can be rendered less effective by participant manipulation by employing a virtual reality crime scenario and multiple countermeasures. Bayesian and bootstrapping analytic approaches were used to classify individuals as guilty or innocent. Guilty subjects were detected significantly less frequently compared to previous studies; countermeasures further reduced the overall hit rates. Innocent participants remained protected from being falsely accused. Reaction times did not prove suitable for accurate classification. Results suggested that guilty verdicts from ERP-based deception detection approaches are likely to be accurate, but that innocent (or indeterminate) verdicts yield no useful interpretation in an applied setting.

Sanguinetti, J. L., Smith, E., Allen, J. J., & Hameroff, S. (2014). Human brain stimulation with transcranial ultrasound (TUS); Potential applications for mental health. Bioelectromagnetic Medicine.

New York, NY: Taylor & Francis. In press.

Chapman, J. P., Chapman, L. J., & Allen, J. J. (1987). The measurement of foot preference. Neuropsychologia, 25(3), 579-584.

PMID: 3683814;Abstract:

Foot preference has been given only superficial attention in studies of hemispheric lateralization, although it has potential utility for predicting hemispheric dominance. This paper reports the development of a reliable (alpha = 0.89) 11-item behavioral inventory of foot preference. Since footedness and handedness are only partially related, both must be measured reliably to identify individuals who have a consistent right or left side preference. It has yet to be determined whether footedness or handedness has the stronger relationship to other aspects of cerebral lateralization and whether both measures together predict lateralization better than one of them alone. © 1987.

Manber, R., Schnyer, R. N., Lyell, D., Chambers, A. S., Caughey, A. B., Druzin, M., Carlyle, E., Celio, C., Gress, J. L., Huang, M. I., Kalista, T., Martin-Okada, R., & J., J. (2010). Acupuncture for depression during pregnancy: A randomized controlled trial. Obstetrics and Gynecology, 115(3), 511-520.

PMID: 20177281;Abstract:

Objective: To estimate the efficacy of acupuncture for depression during pregnancy in a randomized controlled trial. Methods: A total of 150 pregnant women who met Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) criteria for major depressive disorder were randomized to receive either acupuncture specific for depression or one of two active controls: control acupuncture or massage. Treatments lasted 8 weeks (12 sessions). Junior acupuncturists, who were not told about treatment assignment, needled participants at points prescribed by senior acupuncturists. All treatments were standardized. The primary outcome was the Hamilton Rating Scale for Depression, administered by masked raters at baseline and after 4 and 8 weeks of treatment. Continuous data were analyzed using mixed effects models and by intent to treat. Results: Fifty-two women were randomized to acupuncture specific for depression, 49 to control acupuncture, and 49 to massage. Women who received acupuncture specific for depression experienced a greater rate of decrease in symptom severity (P.05) compared with the combined controls (Cohen's d=0.39, 95% confidence interval [CI] 0.01-0.77) or control acupuncture alone (P.05; Cohen's d=0.46, 95% CI 0.01-0.92). They also had significantly greater response rate (63.0%) than the combined controls (44.3%; P.05; number needed to treat, 5.3; 95% CI 2.8-75.0) and control acupuncture alone (37.5%; P.05: number needed to treat, 3.9; 95% CI 2.2-19.8). Symptom reduction and response rates did not differ significantly between controls (control acupuncture, 37.5%; massage, 50.0%). Conclusion: The short acupuncture protocol demonstrated symptom reduction and a response rate comparable to those observed in standard depression treatments of similar length and could be a viable treatment option for depression during pregnancy. © 2010 by The American College of Obstetricians and Gynecologists. Published by Lippincott Williams & Wilkins.