Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Chemistry and Biochemistry-Sci
Associate Professor, BIO5 Institute, Associate Professor, Genetics - GIDP, Associate Professor, Immunobiology, Associate Professor, Surgery
Research Professor, Research Professor, BIO5 Institute
Peptides and proteins play a vital role in almost every cellular process in living organisms. Our research discovers and determines structural information on peptides and proteins to design drugs to more effectively treat human disease.
Professor, Agricultural-Biosystems Engineering, Professor, Arid Lands Resources Sciences - GIDP, Professor, BIO5 Institute
Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Plant Science
I examine the molecular functions of the different cells found in the tissues and organs of plants and animals and how they combine these functions to optimize the health and vigor of the organism.
Professor, BIO5 Institute, Professor, Internal Medicine, Professor, Medicine, Professor, Pharmacology and Toxicology, Professor, Physiological Sciences - GIDP, Professor, Physiology
The Garcia laboratory works to understand the molecular mechanisms of lung inflammatory processes, particularly those producing lung edema or vascular leak. The laboratory focus is to investigate gene discovery, protein function assessment, SNP discovery, genetic manipulation, in vivo testing, and candidate gene and biomarker identification, working to translate basic research into potential novel clinical therapies.
Professor, BIO5 Institute, Professor, Medicine - (Research Scholar Track), Research Scientist
Our lab has a new treatment for heart failure. We have a biodegradable graft seeded with adult human cells that we put on the surface of the heart. The potential is to regenerate new heart muscle
Assistant Director, Cancer Research, Assistant Professor, BIO5 Institute, Assistant Professor, Pharmacology, Assistant Professor, Public Health, Assistant Vice President, Translational Research in Special Populations, Associate Director, Center for Elimination of Border Health, Co-Director, Clinical Translational Sciences - Tucson, Director, BLAISER Program
Director, Epidemiology, Professor, BIO5 Institute, Professor, Medicine - (Tenure Track), Professor, Public Health, Research Scientist, Respiratory Sciences
Stefano Guerra's work includes an epidemiologic study, which used a household-based approach to assess prevalence and longitudinal changes in respiratory health. Other biomarker projects include a study on molecular biomarkers of asthma and COPD from the European Community Respiratory Health Survey.
Associate Director, Omics, Research Scientist, Arizona Research Labs, Research Scientist, BIO5 Institute, Research Scientist, Ecology and Evolutionary Biology, Research Scientist, Neurology

Michael Hammer has headed a productive research lab in human evolutionary genetics. His lab were early adopters of next generation sequencing (NGS) technology successfully employed NGS methods to identify molecular lesions causing neurodevelopmental disorders in undiagnosed children. His lab is also currently pursuing studies to identify modifier genes that alter the expression of major genes and how they contribute to phenotypic heterogeneity in Mendelian disorders.

Executive Director, AHSC Biorepository, Professor, BIO5 Institute, Professor, Immunobiology, Professor, Medicine, Professor, Applied BioSciences - GIDP
We are involved in banking clinical specimens obtained from various patients for use in biomarker discovery and clinical therapies. Clinical therapies may include regenerative medicine, transplant or gene therapy.
Associate Professor, Chemistry and Biochemistry - Med, Associate Professor, Chemistry and Biochemistry-Sci, Associate Professor, Genetics - GIDP, Associate Professor, Molecular and Cellular Biology
The Horton lab uses biophysical, biochemical, and molecular biology to study protein-DNA interactions and filament formation by enzymes. Current projects include the investigation of mechanisms of disease caused by the Human Parvovirus B19, and advantages of filament formation by enzymes such as the sequence specific DNA endonuclease SgrAI, and the important metabolic enzyme PFK.
Director, Biostatistics - Phoenix Campus, Professor, BIO5 Institute, Professor, Public Health, Professor, Statistics-GIDP
Chengcheng Hu has worked on a broad range of areas including cancer, occupational health, HIV/AIDS, and aging. He has extensive collaborative research in conducting methodological research in the areas of survival analysis, longitudinal data, high-dimensional data, and measurement error. His current methodological interest, arising from studies of viral and human genetics and biomarkers, is to develop innovative methods to investigate the relationship between high-dimensional information and longitudinal outcomes or survival endpoints.
Professor, BIO5 Institute, Professor, Pharmacology and Toxicology
The Hulme group is focused on small molecule drug design and developing enabling chemical methodologies to expedite the drug discovery process. The development of small molecule inhibitors of kinases is of particular interest.
Associate Director, BIO5 Institute, Professor, BIO5 Institute, Professor, Medicinal Chemistry-Pharmaceutical Sciences, Professor, Medicinal Chemistry-Pharmacology and Toxicology, Professor, Cancer Biology - GIDP
Laurence Hurley's long-time research interest is in molecular targeting of DNA, first by covalent binders (CC-1065 and psorospermin), then as compounds that target protein–DNA complexes (pluramycins and Et 743), and most recently as four-stranded DNA structures (G-quadruplexes and i-motifs). He was the first to show that targeting G-quadruplexes could inhibit telomerase (Sun et al. [1997] J. Med. Chem., 40, 2113) and that targeting G-quadruplexes in promoter complexes results in inhibition of transcription (Siddiqui-Jain et al. [2002] Proc. Natl. Acad. Sci. U.S.A., 99, 11593).
Assistant Professor, Neuroscience - GIDP, Assistant Professor, Pharmacology
Dr. Khanna has worked in the areas of RNA, RNA-protein, and protein-protein interactions for over 10 years. Dr. Khanna's has a background in chemistry, structural biology, biophysics and drug discovery in neurodegenerative diseases. In her laboratory, she hsa several exciting ongoing projects that all focus on drug discovery using small molecules, peptides and aptamers. The Khanna laboratory develops inhibitors for difficult to target RNA-protein and protein-protein interfaces.
Assistant Professor, BIO5 Institute, Assistant Professor, Biomedical / Materials Science Engineer, Assistant Professor, Biomedical Engineering
Minkyu Kim's research interests are in the areas of biopolymers and biomaterials for advanced national defense and healthcare. He is currently working to develop functional biopolymer materials for the treatment of antimicrobial-resistance diseases and atherosclerosis.
Adjunct Associate Professor, Nursing, Assistant Professor, Medicine - (Research Scholar Track), Associate Professor, BIO5 Institute, Associate Professor, Genetics - GIDP, Associate Professor, Pharmacology and Toxicology, Associate Professor, Public Health, Associate Professor, Veterinary Medicine
Walter Klimecki's research program involves the balance between the particular DNA sequence “versions” of genes that we inherit from our ancestors, and the particular environmental exposures that we experience throughout our lives. The Klimecki lab studies diseases resulting from human exposure to arsenic, contributing to a better understanding of the inherited genetic differences between people that result in altered chemical processing of arsenic after it enters the body.
Assistant Professor, Genetics - GIDP, Associate Professor, BIO5 Institute, Associate Professor, Public Health
I use human genetic data to find associations of genetic markers with complex traits and diseases, to shed light on disease pathophysiology, causal pathways, and health disparities, and to inform precision medicine.
Coordinator, Bac/Est Resource Center
We are a plant genomics lab who specialize in whole genome sequencing and assembly; with analyses of structural variation, gene modeling and transcriptomes. Our work on major projects of rice, corn, barley, etc, allows us to share our technical expertise with other researchers.
Assistant Dean, Graduate Education, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Nutritional Sciences, Professor, Physiological Sciences - GIDP
Kirsten Limesand's research program has its foundation in radiation-induced salivary gland dysfunction; mechanisms of damage, clinical prevention measures, and restoration therapies. They utilize a number of techniques including: genetically engineered mouse models, real-time RT/PCR, immunoblotting, immunohistochemistry, primary cultures, siRNA transfections, and procedures to quantitate salivary gland physiology and integrate this information in order to understand the complete system.
Associate Professor, BIO5 Institute, Associate Professor, Clinical Translational Sciences, Associate Professor, Evelyn F Mcknight Brain Institute, Associate Professor, Medicine, Associate Professor, Molecular and Cellular Biology, Associate Professor, Neurology, Associate Professor, Neuroscience - GIDP, Associate Professor, Physiological Sciences - GIDP
Interim Director, Institute of the Environment, Professor, BIO5 Institute, Professor, Environmental Science-Ext, Professor, Pharmaceutical Sciences, Professor, Pharmacology and Toxicology
Chair, Applied BioSciences - GIDP, Chair, Arid Lands Resources Sciences - GIDP, Professor, Natural Resources and the Environment, Professor, BIO5 Institute, Professor, Plant Sciences
Professor, Applied Mathematics - GIDP, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Genetics - GIDP, Professor, Molecular and Cellular Biology, Professor, Chemistry and Biochemistry-Sci
We investigate how proteins work in healthy organisms and how they fail in disease. We determine the atomic structures of proteins and the underlying biochemistry that gives rise to protein function. We also develop new proteins as drug targets for treating cancer and cardiovascular disease.
Interim Associate Department Head, Research/Faculty Affairs, Professor, BIO5 Institute, Professor, Chemistry and Biochemistry, Professor, Chemistry and Biochemistry-Sci, Professor, Immunobiology
How we sense and react to our environment is communicated in the cell by vast networks of highly dynamic, interacting proteins. These interactions are regulated in both space and time, and it is this tight regulation that allows signals from outside of the cell to be rapidly and precisely transmitted to the nucleus leading to the appropriate, and healthy, cellular response. My research integrates structural biology, biophysics and biochemistry in order to understand how these signals and to develop novel drugs for the treatment of cancer, autoimmune disorders and antibiotic resistance. Lab website:
Associate Vice President, Precision Health Sciences, Associate Vice President, Research, Director, MD/PhD Program, Professor, Internal Medicine, Professor, Medicine
Assistant Professor, Cellular and Molecular Medicine, Assistant Professor, Clinical Translational Sciences, Assistant Professor, Genetics - GIDP, Research Fellow, BIO5 Institute
My laboratory aims to identify the genetic and environmental reasons that certain individuals are predisposed to develop complex diseases like heart disease. We use new technologies, experimental, and computational approaches to identify molecular patterns indicative of disease predisposition.
Associate Professor, BIO5 Institute, Associate Professor, Biomedical Engineering, Associate Professor, Materials Science and Engineering, Associate Professor, Neurosurgery
Associate Professor, Applied BioSciences - GIDP, Associate Professor, BIO5 Institute, Associate Professor, Genetics - GIDP, Associate Professor, Plant Science
My research focus is on functional foods—designing crops to deliver more than mere calories—by both adding nutritional compounds and eliminating anti-nutritional compounds. I work on enhancing seeds of two of the most globally important crops, soybean and corn.
Professor, Applied Mathematics - GIDP, Professor, BIO5 Institute, Regents Professor
Distinguished Outreach Professor, Faculty Director, Diversity and Inclusion, Professor, Applied BioSciences - GIDP, Professor, BIO5 Institute, Professor, Genetics - GIDP, Professor, Molecular and Cellular Biology, Professor, Plant Sciences
Assistant Professor, BIO5 Institute, Assistant Professor, Cellular and Molecular Medicine
We combine chemical and computer vision approaches to discover how regenerative tissues process environmental information to promote accurate cell fate decisions and prevent uncontrolled cell growth.
Bud Antle Endowed Chair For Excellence, Agriculture-Life Sciences, Director, Plant Genomics Institute, Professor, BIO5 Institute, Professor, Ecology and Evolutionary Biology, Professor, Plant Science, Regents Professor
Harnessing 15MY of natural variation in the genus Oryza (rice) to help solve the 10-billion people question: i.e. how do we feed our world without destroying our world.
Assistant Professor, BIO5 Institute, Assistant Professor, Surgery
Professor, Aerospace-Mechanical Engineering, Professor, BIO5 Institute, Professor, Biomedical Engineering