Biotechnology

Professor, Chemistry and Biochemistry-Sci, Professor, Chemistry and Biochemistry - Med, Professor, Biomedical Engineering, Department Head, Member of the Graduate Faculty, Professor, BIO5 Institute
Professor, Immunobiology, Associate Professor, Surgery, Associate Professor, Genetics - GIDP, Associate Professor, Cancer Biology - GIDP, Member of the Graduate Faculty, Associate Professor, BIO5 Institute
Research Professor, Member of the General Faculty , Member of the Graduate Faculty, Research Professor, BIO5 Institute

Peptides and proteins play a vital role in almost every cellular process in living organisms. Our research discovers and determines structural information on peptides and proteins to design drugs to more effectively treat human disease.

Professor, Agricultural-Biosystems Engineering, Professor, Applied BioSciences - GIDP, Professor, Arid Lands Resources Sciences - GIDP, Member of the Graduate Faculty, Professor, BIO5 Institute
Professor, Plant Science, Professor, Biomedical Engineering, Professor, BIO5 Institute

I examine the molecular functions of the different cells found in the tissues and organs of plants and animals and how they combine these functions to optimize the health and vigor of the organism.

Professor, Medicine, Professor, Internal Medicine, Professor, Pharmacology and Toxicology, Professor, Physiology, Professor, Physiological Sciences - GIDP, Professor, BIO5 Institute

The Garcia laboratory works to understand the molecular mechanisms of lung inflammatory processes, particularly those producing lung edema or vascular leak. The laboratory focus is to investigate gene discovery, protein function assessment, SNP discovery, genetic manipulation, in vivo testing, and candidate gene and biomarker identification, working to translate basic research into potential novel clinical therapies.

Professor, Medicine - (Research Scholar Track), Research Scientist, Professor, BIO5 Institute

Our lab has a new treatment for heart failure. We have a biodegradable graft seeded with adult human cells that we put on the surface of the heart. The potential is to regenerate new heart muscle

Director, Epidemiology, Professor, Public Health, Professor, Medicine - (Tenure Track), Research Scientist, Respiratory Sciences, Professor, BIO5 Institute

Stefano Guerra's work includes an epidemiologic study, which used a household-based approach to assess prevalence and longitudinal changes in respiratory health. Other biomarker projects include a study on molecular biomarkers of asthma and COPD from the European Community Respiratory Health Survey.

Associate Director, Omics, Research Scientist, Arizona Research Labs, Research Scientist, Ecology and Evolutionary Biology, Research Scientist, Neurology, Research Scientist, BIO5 Institute

Michael Hammer has headed a productive research lab in human evolutionary genetics. His lab were early adopters of next generation sequencing (NGS) technology successfully employed NGS methods to identify molecular lesions causing neurodevelopmental disorders in undiagnosed children. His lab is also currently pursuing studies to identify modifier genes that alter the expression of major genes and how they contribute to phenotypic heterogeneity in Mendelian disorders.

Executive Director, AHSC Biorepository, Professor, Immunobiology, Professor, Medicine, Professor, Applied BioSciences - GIDP, Professor, BIO5 Institute

We are involved in banking clinical specimens obtained from various patients for use in biomarker discovery and clinical therapies. Clinical therapies may include regenerative medicine, transplant or gene therapy.

Professor, Professor, Chemistry and Biochemistry - Med, Professor, Chemistry and Biochemistry-Sci, Professor, Genetics - GIDP, Member of the Graduate Faculty, Professor, BIO5 Institute

The Horton lab uses biophysical, biochemical, and molecular biology to study protein-DNA interactions and filament formation by enzymes. Current projects include the investigation of mechanisms of disease caused by the Human Parvovirus B19, and advantages of filament formation by enzymes such as the sequence specific DNA endonuclease SgrAI, and the important metabolic enzyme PFK.

Director, Biostatistics - Phoenix Campus, Professor, Public Health, Professor, Statistics-GIDP, Professor, BIO5 Institute

Chengcheng Hu has worked on a broad range of areas including cancer, occupational health, HIV/AIDS, and aging. He has extensive collaborative research in conducting methodological research in the areas of survival analysis, longitudinal data, high-dimensional data, and measurement error. His current methodological interest, arising from studies of viral and human genetics and biomarkers, is to develop innovative methods to investigate the relationship between high-dimensional information and longitudinal outcomes or survival endpoints.

Professor, Pharmacology and Toxicology, Professor, BIO5 Institute

The Hulme group is focused on small molecule drug design and developing enabling chemical methodologies to expedite the drug discovery process. The development of small molecule inhibitors of kinases is of particular interest.

Associate Director, BIO5 Institute, Professor, Medicinal Chemistry-Pharmaceutical Sciences, Professor, Medicinal Chemistry-Pharmacology and Toxicology, Professor, Cancer Biology - GIDP, Professor, BIO5 Institute

Laurence Hurley's long-time research interest is in molecular targeting of DNA, first by covalent binders (CC-1065 and psorospermin), then as compounds that target protein–DNA complexes (pluramycins and Et 743), and most recently as four-stranded DNA structures (G-quadruplexes and i-motifs). He was the first to show that targeting G-quadruplexes could inhibit telomerase (Sun et al. [1997] J. Med. Chem., 40, 2113) and that targeting G-quadruplexes in promoter complexes results in inhibition of transcription (Siddiqui-Jain et al. [2002] Proc. Natl. Acad. Sci. U.S.A., 99, 11593).

Assistant Professor, Biomedical / Materials Science Engineer, Assistant Professor, Biomedical Engineering, Member of the Graduate Faculty, Assistant Professor, BIO5 Institute

Minkyu Kim's research interests are in the areas of biopolymers and biomaterials for advanced national defense and healthcare. He is currently working to develop functional biopolymer materials for the treatment of antimicrobial-resistance diseases and atherosclerosis.

Associate Professor, Veterinary Medicine, Assistant Professor, Medicine - (Research Scholar Track), Associate Professor, Pharmacology and Toxicology, Associate Professor, Public Health, Associate Professor, Genetics - GIDP, Adjunct Associate Professor, Nursing, Associate Professor, BIO5 Institute

Walter Klimecki's research program involves the balance between the particular DNA sequence “versions” of genes that we inherit from our ancestors, and the particular environmental exposures that we experience throughout our lives. The Klimecki lab studies diseases resulting from human exposure to arsenic, contributing to a better understanding of the inherited genetic differences between people that result in altered chemical processing of arsenic after it enters the body.

Associate Professor, Public Health, Assistant Professor, Genetics - GIDP, Associate Professor, BIO5 Institute

I use human genetic data to find associations of genetic markers with complex traits and diseases, to shed light on disease pathophysiology, causal pathways, and health disparities, and to inform precision medicine.

Coordinator, Bac/Est Resource Center
We are a plant genomics lab who specialize in whole genome sequencing and assembly; with analyses of structural variation, gene modeling and transcriptomes. Our work on major projects of rice, corn, barley, etc, allows us to share our technical expertise with other researchers.
Professor, Nutritional Sciences, Professor, Cancer Biology - GIDP, Professor, Physiological Sciences - GIDP, Assistant Dean, Graduate Education, Professor, BIO5 Institute

Kirsten Limesand's research program has its foundation in radiation-induced salivary gland dysfunction; mechanisms of damage, clinical prevention measures, and restoration therapies. They utilize a number of techniques including: genetically engineered mouse models, real-time RT/PCR, immunoblotting, immunohistochemistry, primary cultures, siRNA transfections, and procedures to quantitate salivary gland physiology and integrate this information in order to understand the complete system.

Associate Professor, Neurology, Associate Professor, Medicine, Associate Professor, Neuroscience - GIDP, Associate Professor, Molecular and Cellular Biology, Associate Professor, Evelyn F Mcknight Brain Institute, Associate Professor, Clinical Translational Sciences, Associate Professor, Physiological Sciences - GIDP, Associate Professor, BIO5 Institute
Professor, Environmental Science, Professor, Pharmaceutical Sciences, Professor, Pharmacology and Toxicology, Professor, BIO5 Institute
Professor, Chemistry and Biochemistry-Sci, Professor, Molecular and Cellular Biology, Professor, Applied Mathematics - GIDP, Professor, Cancer Biology - GIDP, Professor, Genetics - GIDP, Professor, BIO5 Institute

We investigate how proteins work in healthy organisms and how they fail in disease. We determine the atomic structures of proteins and the underlying biochemistry that gives rise to protein function. We also develop new proteins as drug targets for treating cancer and cardiovascular disease.

Assistant Professor, Cellular and Molecular Medicine, Assistant Professor, Clinical Translational Sciences, Assistant Professor, Genetics - GIDP, Research Fellow, BIO5 Institute

My laboratory aims to identify the genetic and environmental reasons that certain individuals are predisposed to develop complex diseases like heart disease. We use new technologies, experimental, and computational approaches to identify molecular patterns indicative of disease predisposition.

Associate Professor, Biomedical Engineering, Associate Professor, Materials Science and Engineering, Associate Professor, Neurosurgery, Member of the Graduate Faculty, Associate Professor, BIO5 Institute
Associate Professor, Plant Science, Associate Professor, Applied BioSciences - GIDP, Associate Professor, Genetics - GIDP, Associate Professor, BIO5 Institute

My research focus is on functional foods—designing crops to deliver more than mere calories—by both adding nutritional compounds and eliminating anti-nutritional compounds. I work on enhancing seeds of two of the most globally important crops, soybean and corn.

Professor, Chemistry and Biochemistry-Sci , Professor, Applied Mathematics - GIDP, Regents Professor, Professor, BIO5 Institute
Assistant Professor, Biomedical Engineering, Assistant Professor, BIO5 Institute, Member of the Graduate Faculty, Member of the General Faculty

Using engineered biomaterials and cell therapy, my lab develops organ-on-chip systems and artificial implantable organs/devices for diagnostics and therapeutics. I focus on student-centered teaching with hands-on learning experience. I'm a strong advocate for women, URM, first-gen, and non-traditional students (veterans) in STEM education.

Associate Dean, Student Affairs, Diversity & Inclusion, Faculty Director, Diversity and Inclusion, Distinguished Outreach Professor, Professor, Applied BioSciences - GIDP, Professor, Genetics - GIDP, Professor, Molecular and Cellular Biology, Professor, Plant Sciences, Professor, BIO5 Institute
Assistant Professor, Cellular and Molecular Medicine, Assistant Professor, BIO5 Institute

We combine chemical and computer vision approaches to discover how regenerative tissues process environmental information to promote accurate cell fate decisions and prevent uncontrolled cell growth.

Director, Plant Genomics Institute, Bud Antle Endowed Chair For Excellence, Agriculture-Life Sciences, Professor, Plant Science, Professor, Ecology and Evolutionary Biology, Regents Professor, Professor, BIO5 Institute

Harnessing 15MY of natural variation in the genus Oryza (rice) to help solve the 10-billion people question: i.e. how do we feed our world without destroying our world.

Assistant Professor, Surgery, Assistant Professor, BIO5 Institute
Professor, Aerospace-Mechanical Engineering, Professor, Biomedical Engineering, Professor, BIO5 Institute