Medicine
Professor, Pathology - (Research Scholar Track), Research Professor, BIO5 Institute
The personalized diagnosis, prognosis and treatment of cancer.
Distinguished Professor, Professor, BIO5 Institute, Professor, Cognitive Science - GIDP, Professor, Psychology, Professor, Neuroscience - GIDP
Depression is a major health problem that is often chronic or recurrent. Existing treatments have limited effectiveness, and are provided wihtout a clear indication that they will match a particular patient's needs. In this era of precision medicine, we strive to develop neurally-informed treatments for depression and related disorders.
Professor, BIO5 Institute, Professor, Evelyn F Mcknight Brain Institute, Professor, Physiology, Professor, Speech/Language and Hearing
Associate Professor, Medicine - (Research Scholar Track), Coordinator, Phase I/II Clinical Trials, Research Assistant Professor, BIO5 Institute, Associate Professor, Pharmacy Practice-Science
Associate Professor, Animal and Comparative Biomedical Sciences, Associate Professor, Plant Sciences
We are interested in understanding the genetic basis for bacterial interactions with other organisms (be they plants, insects, fungi, other bacteria), and on how evolution shapes these interactions. By better understanding the rules and molecules that structure such relationships, we hope to develop new ways to manipulate these interactions (e.g. through the development of specific antimicrobial compounds) or shape their evolutionary dynamics through time.
Director, BIO5 Institute, Professor, Agricultural-Biosystems Engineering, Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Electrical and Computer Engineering, Professor, Medical Imaging, Professor, Optical Sciences
I develop new optical imaging devices that can detect cancer at the earliest stage. Optics has the resolution and sensitivity to find these small, curable lesions, and we design the endoscope that provide access to organs inside the body. .
Associate Director, Statistical Consulting, Professor, BIO5 Institute, Professor, Public Health, Professor, Statistics-GIDP
Department Head, Speech/Language and Hearing, Professor, BIO5 Institute, Professor, Cognitive Science - GIDP, Professor, Speech/Language and Hearing
Adjunct Associate Professor, Animal and Comparative Biomedical Sciences, Associate Research Scientist, BIO5 Institute, Director/Attending Veterinarian, University Animal Care, Veterinary Specialist
Associate Professor, Pharmacology, Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Medicine, Professor, Physiological Sciences - GIDP, Professor, Physiology
Professor, BIO5 Institute, Professor, Entomology / Insect Science - GIDP, Professor, Plant Science, Regents Professor, Plant Sciences, Research Associate Professor, Entomology
Unravel the phylodynamics and transmission-specific determinants of emerging plant virus/fastidious bacteria-insect vector complexes, and translate new knowledge to abate pathogen spread in food systems.
Research Professor, Research Professor, BIO5 Institute
Peptides and proteins play a vital role in almost every cellular process in living organisms. Our research discovers and determines structural information on peptides and proteins to design drugs to more effectively treat human disease.
Associate Professor, BIO5 Institute, Associate Professor, Cancer Biology - GIDP, Associate Professor, Immunobiology, Associate Professor, Molecular and Cellular Biology
We aim to understand the mechanisms of HPV infection, the cellular responses to HPV infection, and how the interplay between host and virus influences the outcome
Associate Professor, BIO5 Institute, Associate Professor, Clinical Translational Sciences, Associate Professor, Neurosurgery, Associate Professor, Otolaryngology, Vice Chair, Academic Affairs - Otolaryngology
Department Chair, Epidemiology and Biostatistics, Distinguished Professor, Professor, Anthropology, Professor, BIO5 Institute, Professor, Statistics-GIDP
Associate Dean, Research and Graduate Studies - College of Pharmacy, Director, Southwest Environmental Health Science Center, Professor, BIO5 Institute, Professor, Clinical Translational Sciences, Professor, Pharmacology and Toxicology, Professor, Public Health
Assistant Professor, BIO5 Institute, Assistant Professor, Cognitive Science - GIDP, Assistant Professor, Evelyn F Mcknight Brain Institute, Assistant Professor, Psychology
Division Chief, Infectious Disease, Professor, BIO5 Institute, Professor, Immunobiology, Professor, Medicine
Dr. Connick is a physician scientist who has dedicated her career to the improvement of health of individuals living with or at risk for HIV-1 infection. Her research ranges from laboratory based investigations of HIV-1 immunopathogenesis to clinical and epidemiological studies of novel immunotherapies and other interventions to improve health outcomes in people living with HIV-1.
Director, Cutaneous Oncology Program, Professor, BIO5 Institute, Professor, Medicine - (Tenure Track)
Professor, BIO5 Institute, Professor, Neuroscience - GIDP, Professor, Pharmacology, Professor, Pharmacology and Toxicology, Professor, Physiological Sciences - GIDP
Professor, BIO5 Institute, Professor, Emergency Medicine, Professor, Optical Sciences
Associate Professor, BIO5 Institute, Associate Professor, Immunobiology, Associate Professor, Neurology, Associate Professor, Neuroscience - GIDP, Associate Professor, Neurosurgery, Associate Professor, Psychology, Research Scientist
Approximately 795,000 Americans suffer a stroke each year, and 400,000 will experience long-term disability. The number of stroke survivors in the population is expected to double by 2025. Currently, treatments for stroke patients are limited to tissue plasminogen activator (TPA), but its use is limited to the first few hours after stroke. Therefore, the goal of our research is to develop new therapeutics that can promote repair and recovery in this rapidly growing population.
Assistant Professor, BIO5 Institute, Assistant Professor, Gastrointestinal Microbiology, Assistant Professor, Physiological Sciences - GIDP
Clinical Instructor, Pharmacy Practice-Science, Professor, BIO5 Institute, Professor, Medicine, Professor, Nutritional Sciences, Professor, Physiological Sciences - GIDP
Janet Funk's work includes a focus on metastatic breast cancer that spans the research spectrum from bench to bedside, translational arthritis studies of the pharmacokinetics and safety of turmeric, and collaborative endocrinological studies evaluating the effects of obesity and insulin resistance on bone development in Hispanic girls, as well as effects of obesity on breast cancer risk in older women.
Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Plant Science
I examine the molecular functions of the different cells found in the tissues and organs of plants and animals and how they combine these functions to optimize the health and vigor of the organism.
Director, Valley Fever Center for Excellence, Professor, BIO5 Institute, Professor, Medicine
Valley Fever (coccidioidomycosis) occurs more in Arizona than anywhere else. My research and others at the Valley Fever Center for Excellence involve understanding how disease is caused by infection, how the immune system stops or prevents illness, and how we can better diagnose, treat, or prevent this public health problem.
Professor, BIO5 Institute, Professor, Internal Medicine, Professor, Medicine, Professor, Pharmacology and Toxicology, Professor, Physiological Sciences - GIDP, Professor, Physiology
The Garcia laboratory works to understand the molecular mechanisms of lung inflammatory processes, particularly those producing lung edema or vascular leak. The laboratory focus is to investigate gene discovery, protein function assessment, SNP discovery, genetic manipulation, in vivo testing, and candidate gene and biomarker identification, working to translate basic research into potential novel clinical therapies.
Department Head, Nutritional Sciences, Professor, BIO5 Institute, Professor, Nutritional Sciences, Professor, Physiological Sciences - GIDP, Professor, Physiology, Professor, Public Health
Scott Going is an expert in models and methods for assessment of changes in body composition during growth, and with aging, and is currently investigating the effects of chronic exercise versus hormone replacement therapy on bone, soft tissue composition and muscle strength in postmenopausal women, as well as the role of exercise in obesity prevention in children.
Associate Research Professor
Vijay Gokhale's work includes the use of medicinal chemistry in the development of small molecule therapeutics for neuropathic pain, idiopathic pulmonary fibrosis (IPF), and acute lung injury and cancer.
Assistant Director, Cancer Research, Assistant Professor, BIO5 Institute, Assistant Professor, Pharmacology, Assistant Professor, Public Health, Assistant Vice President, Translational Research in Special Populations, Associate Director, Center for Elimination of Border Health, Co-Director, Clinical Translational Sciences - Tucson, Director, BLAISER Program
Director, Epidemiology, Professor, BIO5 Institute, Professor, Medicine - (Tenure Track), Professor, Public Health, Research Scientist, Respiratory Sciences
Stefano Guerra's work includes an epidemiologic study, which used a household-based approach to assess prevalence and longitudinal changes in respiratory health. Other biomarker projects include a study on molecular biomarkers of asthma and COPD from the European Community Respiratory Health Survey.
Director, Natural Products Center, Professor, Arid Lands Resources Sciences - GIDP, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Natural Resources and the Environment, Professor, Pharmacology and Toxicology
Discovery of natural products from plants and their associated microorganisms as potential drugs to treat cancer. Application of medicinal chemistry approach for structure-activity relationship studies and to obtain compounds for preclinical evaluation. Development of alternative agricultural systems for sustainable utilization of natural resources.
Executive Director, AHSC Biorepository, Professor, BIO5 Institute, Professor, Immunobiology, Professor, Medicine, Professor, Applied BioSciences - GIDP
We are involved in banking clinical specimens obtained from various patients for use in biomarker discovery and clinical therapies. Clinical therapies may include regenerative medicine, transplant or gene therapy.
Associate Professor, BIO5 Institute, Associate Professor, Physiological Sciences - GIDP, Co-Chair, ABBS Program, Professor, Cellular and Molecular Medicine
The long-term goal of research in my lab is to understand the molecular mechanisms of muscle contraction. I am especially interested in how contractile proteins of muscle sarcomeres regulate the force and speed of contraction in the heart. The question is important from both basic science and clinical perspectives because mutations in sarcomere proteins of muscle are a leading cause of hypertrophic cardiomyopathy (HCM), the most common cause of sudden cardiac death in the young and a prevalent cause of heart failure in adults. Myosin binding protein-C (MyBP-C) is a muscle regulatory protein that speeds actomyosin cycling kinetics in response to adrenaline (b-adrenergic stimuli) and is one of the two most commonly affected proteins linked to HCM. Currently, the major research focus in my lab is understanding the mechanisms by which cMyBP-C regulates contractile speed and mechanisms by which mutations in cMyBP-C cause disease.
Professor, BIO5 Institute, Professor, Evelyn F Mcknight Brain Institute, Professor, Physiology, Professor, Psychology, Professor, Physiological Sciences - GIDP
Our lab is focused on the development of novel peptides to inhibit this inflammatory cascade and improve brain blood flow. These peptides are designed to significantly improve serum half-life and penetrate the blood-brain-barrier. These peptides act to inhibit the inflammatory pathways at both the level of brain blood vessels and the brain itself.
Associate Professor, BIO5 Institute, Associate Professor, Clinical Translational Sciences, Associate Professor, Medicine
Louise Hecker’s research is focused on understanding why the process of regenerative biology and mechanisms of tissue injury-repair "goes awry" in aging. She is working to identifying novel pathways that can be targeted to reverse age-associated diseases, such as Idiopathic pulmonary fibrosis (IPF).
Associate Professor, BIO5 Institute, Associate Professor, Basic Medical Sciences, Associate Professor, Clinical Translational Sciences, Associate Professor, Obstetrics and Gynecology
Associate Professor, BIO5 Institute, Associate Professor, Nutritional Sciences, Associate Professor, Public Health
Melanie Hingle's work focuses on understanding determinants of energy balance behaviors (i.e. how and why behaviors are initiated and sustained), and identifying contributors to the success of interventions (i.e. when, where, and how interventions should be delivered) are critical steps toward developing programs that effectively change behavior, thereby mitigating unhealthy weight gain and promoting optimal health. Current projects include: Determinants of metabolic risk, and amelioration of risk, in pediatric cancer survivors, Guided imagery intervention delivered via a mobile software application to increase healthy eating and physical activity in weight-concerned women smokers, and Family-focused diabetes prevention program delivered in partnership with the YMCA.
Professor, Professor, BIO5 Institute, Professor, Chemistry and Biochemistry - Med, Professor, Chemistry and Biochemistry-Sci, Professor, Genetics - GIDP
The Horton lab uses biophysical, biochemical, and molecular biology to study protein-DNA interactions and filament formation by enzymes. Current projects include the investigation of mechanisms of disease caused by the Human Parvovirus B19, and advantages of filament formation by enzymes such as the sequence specific DNA endonuclease SgrAI, and the important metabolic enzyme PFK.
Director, Biostatistics - Phoenix Campus, Professor, BIO5 Institute, Professor, Public Health, Professor, Statistics-GIDP
Chengcheng Hu has worked on a broad range of areas including cancer, occupational health, HIV/AIDS, and aging. He has extensive collaborative research in conducting methodological research in the areas of survival analysis, longitudinal data, high-dimensional data, and measurement error. His current methodological interest, arising from studies of viral and human genetics and biomarkers, is to develop innovative methods to investigate the relationship between high-dimensional information and longitudinal outcomes or survival endpoints.
Assistant Professor, BIO5 Institute, Assistant Professor, Biomedical Engineering
Associate Professor, BIO5 Institute, Associate Professor, Chemistry and Biochemistry-Sci
We seek to develop tools and strategies to expedite the understanding and treatment of the dengue virus. These advances will be transferable to other areas of virology and biochemistry. Along these lines, we are engaged in three core synergistic projects to answer the following questions:
(1) Do unnatural metabolites incorporated into DENV serve as reporters for host-pathogen interactions?
(2) What are the host-pathogen interactions in DENV that are targetable for diagnosis or treatment?
(3) Is there a chemical reaction between two small molecules that reports on the interaction between DENV and host proteins?
Assistant Professor, Immunobiology, Assistant Professor, BIO5 Institute
Metals such as calcium and iron are essential to living organisms. Some metals in excess, like copper, are detrimental to bacteria. My laboratory studies this phenomenon in Streptococcus pneumoniae to find novels method for killing pathogenic bacteria.
Assistant Professor, BIO5 Institute, Assistant Professor, Biomedical Engineering, Assistant Professor, Optical Sciences
We are developing low-cost in vivo microscopy devices that can visualize cellular details of human tissues in vivo and help disease diagnosis and treatment in low-resource settings, high-speed tissue microscopy technologies that can examine entire organ under risk of having malignant diseases and detect small, early-stage lesions, and miniature microscopy devices that have the potential to examine anatomically-challenging human organs and facilitate integration of microscopic imaging with other imaging modalities.
Professor, BIO5 Institute, Professor, Immunobiology, Professor, Medicine, Professor, Pathology, Professor, Pediatrics, Program Director, Blood and Bone Marrow Transplant, Professor, Cancer Biology - GIDP
Augmenting immune responses to cancer. Reducing relapse and graft versus host disease after hematopoietic cell transplantation.
Professor, Medical Imaging, Professor, Neurology, Professor, BIO5 Institute
Chelsea Kidwell specializes in prevention and treatment of stroke. She has special interests in medical imaging and stroke as well as ethnic and racial disparities among stroke patients.
Assistant Professor, BIO5 Institute, Assistant Professor, Cognitive Science - GIDP, Assistant Professor, Speech/Language and Hearing
My research examines neural factors which affect language functions, and how these change across life-span and are influenced by stroke, brain injury and neurodegenerative disorders. In my work, I use combination of cognitive measures and multimodal neuroimaging techniques (fMRI, EEG/ERPs, MEG). I am also interested in recovery of function, and treatment approaches involving speech-language therapy in combination with noninvasive brain stimulation techniques.
Assistant Professor, Genetics - GIDP, Associate Professor, BIO5 Institute, Associate Professor, Public Health
I use human genetic data to find associations of genetic markers with complex traits and diseases, to shed light on disease pathophysiology, causal pathways, and health disparities, and to inform precision medicine.
Associate Professor, Associate Professor, BIO5 Institute, Associate Professor, Evelyn F Mcknight Brain Institute, Associate Professor, Immunobiology, Associate Professor, Medicine, Associate Professor, Neuroscience - GIDP
We study how a common intracellular parasite, Toxoplasma gondii, persists in, and potentially changes, the mammalian brain. Understanding the Toxoplasma-brain interaction offers the opportunity to develop better therapies to treat toxoplasmosis as well as giving new insights into how to manipulate the brain immune response which has been implicated in many neurodegenerative diseases.
Chair, Department of Medicine, Professor, BIO5 Institute, Professor, Medicine
Monica Kraft's research focus is in the areas of adult asthma, the role of infection in asthma and the role of the distal lung in asthma and airway remodeling.
Associate Professor, Immunobiology, Associate Professor, BIO5 Institute, Associate Professor, Genetics - GIDP
Michael Kuhns' research program is focused on (i) increasing our basic understanding of how T cell fate decisions are made (e.g. development, activation, differentiation, effector functions), and (ii) increasing their working knowledge of how to manipulate these decisions to direct T cells towards a desired outcome, such as increasing responses to vaccines or tumors, preventing transplant rejection, or attenuating autoimmunity.
Professor, Applied Mathematics - GIDP, Professor, BIO5 Institute, Professor, Mathematics
I develop mathematics of biomedical imaging. All modalities of tomography imaging rely heavily on mathematical algorithms for forming an image. I develop the theory and the algorithm enabling this technology.
Investigator, Center for Toxicology, Professor, BIO5 Institute, Professor, Cellular and Molecular Medicine, Professor, Public Health
We are interested in the effects of early life exposures to environmental toxicants on lung growth and development. We determine if the early life exposures leads to adult disease.
Associate Professor, BIO5 Institute, Associate Professor, Cellular and Molecular Medicine, Associate Professor, Clinical Translational Sciences, Associate Professor, Immunobiology, Associate Professor, Medicine
Julie Ledford's research focuses on respiratory disease, and genetic and molecular mechanisms of allergic airway diseases in children.
Professor, Child Health - (Research Scholar Track)
Jonathan Lifshitz's research questions primarily investigate traumatic brain injury as a disease process that dismantles, repairs and regenerates circuits in the brain. The underlying principle is that adaptive repair and regeneration fail, leaving a miswired brain and neurological impairments that decrease quality of life.
Assistant Dean, Graduate Education, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Nutritional Sciences, Professor, Physiological Sciences - GIDP
Kirsten Limesand's research program has its foundation in radiation-induced salivary gland dysfunction; mechanisms of damage, clinical prevention measures, and restoration therapies. They utilize a number of techniques including: genetically engineered mouse models, real-time RT/PCR, immunoblotting, immunohistochemistry, primary cultures, siRNA transfections, and procedures to quantitate salivary gland physiology and integrate this information in order to understand the complete system.
Chair, Institutional Animal Care-USE Committee, Director, Agriculture Research Complex, Professor, Animal and Comparative Biomedical Sciences, Professor, BIO5 Institute, Professor, Obstetrics and Gynecology, Professor, Physiological Sciences - GIDP
Our current research program use an integrative approach at the whole animal, isolated organ, cellular and molecular levels to investigate developmental adaptations in pancreatic β-cells and insulin sensitivity that result from early life risk factors, such as intrauterine growth restriction, and increase risk of glucose intolerance and Diabetes in later life.
Associate Professor, Cellular and Molecular Medicine, Associate Professor, BIO5 Institute, Associate Professor, Immunobiology
Associate Director, Shared Resources, Associate Professor, Pharmacology, Director, Aribi Institute, Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Physiological Sciences - GIDP, Professor, Physiology
Precise diagnosis and treatment of disease requires an ability to target agents to specific tissues and cell types within those tissues. We are developing agents that exhibit cell type specificity for these purposes.
Director, Asthma / Airway Disease Research Center, Endowed Chair, Swift - McNear, Professor, BIO5 Institute, Professor, Pediatrics, Regents Professor, Professor, Genetics - GIDP
Assistant Professor, Cancer Biology - GIDP, Assistant Professor, Cellular and Molecular Medicine, Assistant Professor, Genetics - GIDP, Research Associate Professor, Medicine
Assistant Professor, BIO5 Institute, Assistant Professor, Molecular and Cellular Biology, Assistant Professor, Pediatrics, Assistant Professor, Cancer Biology - GIDP
Distinguished Professor, Chemistry and Biochemistry, Professor, BIO5 Institute, Professor, Chemistry and Biochemistry, Professor, Entomology / Insect Science - GIDP, Professor, Molecular and Cellular Biology
Associate Professor, BIO5 Institute, Associate Professor, Chemistry and Biochemistry-Sci
We seek to produce new drugs that harness molecules produced during the natural immune response in order to treat cancer and pain. Such compounds may also provide new treatments for heart failure and alcoholism.
Co-Program Leader, Cancer Biology Research Program, Professor, BIO5 Institute, Professor, Cellular and Molecular Medicine
Co-Director, Arizona Center on Aging, Department Head, Immunobiology, Professor, BIO5 Institute, Professor, Immunobiology, Professor, Medicine, Professor, Nutritional Sciences, Professor, Genetics - GIDP, Professor, Neuroscience - GIDP
Associate Vice President, Clinical Research / Global Health Initiatives, Professor, BIO5 Institute, Professor, Medicine, Professor, Mel and Enid Zuckerman College of Public Health
Professor, Animal and Comparative Biomedical Sciences, Professor, BIO5 Institute, Professor, Medical Imaging - (Research Scholar Track), Professor, Physiological Sciences - GIDP, Professor, Surgery
Division Chief, Pulmonary / Allergy - Critical Care and Sleep Medicine, Professor, Clinical Translational Sciences, Professor, Medicine
Dr. Parthasarathy has expertise in noninvasive home ventilation for sleep-related breathing disorders and invasive ventilation in critically ill patients. His major areas of focus have been in promoting adherence to nonivasive ventilation devices in the home setting and patient-ventilator interaction during critical illness. He serves as Chief of Division of Pulmonary, Allergy, Critical Care & Sleep Medicine at COM-T and as a Special Advisor to NH/NHLBI.
Research Scientist, Speech/Language and Hearing
I analyze MRI images to understand more about how human language works. We use functional MRI to determine which brain regions are involved in different language tasks. We also look at diffusion MRI to learn about the quality of the wiring between regions.
Assistant Professor, BIO5 Institute, Assistant Professor, Public Health, Associate Veterinary Specialist, Animal and Comparative Biomedical Sciences
Assistant Professor, BIO5 Institute, Assistant Professor, Physiological Sciences - GIDP, Assistant Research Scientist, Associate Professor, Medicine
Endowed Chair, Thomas R Brown - Biomedical Engineering, Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Electrical and Computer Engineering
Our group develops rapid, inexpensive tools for the immediate discovery and identification of infectious diseases. It is critical for highly populated areas and resource-poor environments to have access to immediate therapeutics to save their populations and prevent the spread of these diseases.
Associate Vice President, Precision Health Sciences, Associate Vice President, Research, Director, MD/PhD Program, Professor, Internal Medicine, Professor, Medicine
Associate Professor, Animal and Comparative Biomedical Sciences, Associate Professor, BIO5 Institute
Associate Professor, Animal and Comparative Biomedical Sciences, Associate Professor, BIO5 Institute, Associate Professor, Nutritional Sciences, Associate Professor, Physiological Sciences - GIDP
Renquist Lab Research aims to address the causes and consequent diseases of obesity. To this end we have research focused on 1) type 2 diabetes and obesity associated hypertension, 2) development of effective, ligand-directed, chemotherapeutic for cancer, and 3) central nervous system control of visceral blood flow and food intake.
Professor, BIO5 Institute, Professor, Entomology, Professor, Entomology / Insect Science - GIDP
Our work seeks to develop novel approaches towards controlling mosquito-borne diseases. We are interested in better understanding the relationship between the mosquito vector and the pathogens they transmit. Through genetic engineering we hope to generate fit, pathogen resistant mosquitoes that could be used to control the spread of mosquito-borne diseases.
Professor, Aerospace-Mechanical Engineering, Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Cellular and Molecular Medicine, Professor, Physiology, Professor, Surgery
Assistant Professor, Cellular and Molecular Medicine, Assistant Professor, Clinical Translational Sciences, Assistant Professor, Genetics - GIDP, Research Fellow, BIO5 Institute
My laboratory aims to identify the genetic and environmental reasons that certain individuals are predisposed to develop complex diseases like heart disease. We use new technologies, experimental, and computational approaches to identify molecular patterns indicative of disease predisposition.
Associate Professor, Nutritional Sciences
The aims of our efforts are to elucidate the science of nutrient-responsive sensing and signaling processes in human systems and to rationally apply this knowledge in development of effective interventions. We apply three approaches in these endeavors; namely: 1. Integrative omics to: a) characterize | catalog structural chemistry and molecular dynamics of nutrient-responsive human systems (receptors, transporters, enzymes and hormones); and, b) determine functional implications of structural variation in elements of these systems. 2. Physiological optics to characterize in vivo human response to nutrient intake (tissue status change and retinal | visual function). 3. Ultra-structural | membrane | organoid biophysics to identify modifiable ('druggable') mechanisms and rate-limiting steps of nutrient sensing | signaling in human retina and brain.
Associate Professor, BIO5 Institute, Associate Professor, Ecology and Evolutionary Biology, Associate Professor, Entomology, Associate Professor, Entomology / Insect Science - GIDP, Associate Professor, Genetics - GIDP, Associate Professor, Molecular and Cellular Biology, Associate Professor, Neuroscience - GIDP
Associate Professor, Applied BioSciences - GIDP, Associate Professor, BIO5 Institute, Associate Professor, Pathology - (Research Scholar Track)
We are studying how tumor cells escape immunosurveillance, a hallmark of cancer, in aggressive lymphomas. MHCII is a protein important for immunosurveillance. We are studying the underlying mechanisms of altered regulation of MHCII in lymphoma cells and its effects on tumor immunosurveillance.
Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Genetics - GIDP, Professor, Molecular and Cellular Biology, Department Head, Molecular and Cellular Biology
Professor, Applied Mathematics - GIDP, Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Mathematics, Professor, Physiological Sciences - GIDP, Professor, Physiology, Research Professor, Arizona Research Labs
Associate Professor, Cancer Biology - GIDP, Associate Professor, Immunobiology, Associate Professor, Nutritional Sciences, Associate Professor, Pediatrics, Associate Professor, Physiological Sciences - GIDP
Director, Microbial Pathogenesis Program, Professor, Animal and Comparative Biomedical Sciences, Professor, BIO5 Institute, Professor, Biochemistry/Molecular Biophysics, Professor, Genetics - GIDP, Professor, Immunobiology, Professor, Molecular and Cellular Biology
How do bacteria "talk" to the body? How does the body reply to the microbe? How does this conversation affect your health and well being?
Adjunct Associate Professor, Aerospace-Mechanical Engineering, Adjunct Associate Professor, Materials Science and Engineering, Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Orthopaedic Surgery, Professor, Physiological Sciences - GIDP
Director, Canyon Ranch Center for Prevention and Health Promotion, Distinguished Professor, Professor, BIO5 Institute, Professor, Clinical Translational Sciences, Professor, Medicine, Professor, Nutritional Sciences Graduate Program, Professor, Public Health
Co-Director, MD/PhD Dual Degree Program, Department Head, Pharmacology, Professor, Anesthesiology, Professor, BIO5 Institute, Professor, Neurology, Professor, Neuroscience - GIDP, Professor, Pharmacology, Professor, Physiological Sciences - GIDP
Co-Director, Collaboratory for Anti-infectives & Therapeutics, Professor, Animal and Comparative Biomedical Sciences, Professor, BIO5 Institute, Professor, Immunobiology
Our research efforts focus on bacteria that cause serious healthcare-associated infections, and those associated with antibiotic use. This infections disproportiOur federally-funded research focuses on infection prevention. Specifically, we study diseases such as Clostridium difficile Infection that affect populations worldwide ("One-Health" issue). Our current efforts are aimed at translating bench-research findings to the bedside. We have recently been awarded two patents for a novel biologic agent invention aimed at preventing bacterial infections in humans as well as food animals.onately affect the elderly, and those with compromised immune systems. One overarching goal of our studies is to develop safe, cost-effective, non-antibiotic interventions to prevent and treat bacterial diarrheas.
Director, Arizona Center for the Biology of Complex Diseases (ABCD), Professor, BIO5 Institute, Professor, Cellular and Molecular Medicine, Professor, Genetics - GIDP, Associate Director, Asthma / Airway Disease Research Center
Associate Professor, Animal and Comparative Biomedical Sciences, Associate Professor, BIO5 Institute
Ninety children die every hour due to diarrhea. My laboratory uses the latest technology to understand how bacteria cause diarrhea in children. In addition to providing clues for new ways to prevent disease, our research helps us understand how the body maintains good health.
Assistant Professor, Applied BioSciences - GIDP, Assistant Research Professor, Director, Viper Institute
Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Cellular and Molecular Medicine, Professor, Neuroscience - GIDP, Director, Willed Body Program
Associate Professor, Applied Mathematics - GIDP, Associate Professor, BIO5 Institute, Associate Professor, Neuroscience - GIDP, Associate Professor, Optical Sciences, Professor, Biomedical Engineering, Professor, Medical Imaging, Professor, Neurosurgery
We develop cutting-edge imaging technology, integrating light, ultrasound and electricity, to diagnose and treat diseases ranging from epilepsy to breast cancer. Novel sources for ultrasound contrast include optical and microwave absorption, mechanical strain, and electrical current. We visualize electrical brain “stormsˮ during uncontrollable seizures and envision “smartˮ photoacoustic agents that seek-and-destroy deadly tumors.
Director, Clinical Decision Support, Professor, Biomedical Informatics - (Research Scholar Track), Professor, Internal Medicine - (Research Scholar Track)
Associate Director, Microbiome, Department Head, Ecology and Evolutionary Biology, Professor, BIO5 Institute, Professor, Ecology and Evolutionary Biology, Professor, Genetics - GIDP
Professor, BIO5 Institute, Professor, Pharmacology and Toxicology, Professor, Cancer Biology - GIDP
Professor, Agricultural-Biosystems Engineering, Professor, Animal and Comparative Biomedical Sciences, Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Chemistry and Biochemistry-Sci
Professor, Applied BioSciences - GIDP, Professor, BIO5 Institute, Professor, Cellular and Molecular Medicine, Professor, Genetics - GIDP, Professor, Molecular and Cellular Biology, Professor, Neurology, Professor, Neuroscience, Professor, Neuroscience - GIDP
We are working to uncover the molecular mechanisms of aging and neurodegenerative diseases using a combination of genetic, computational and pharmacological tools, and a diverse array of experimental models. We also seek to develop therapies for ALS and related neurodegenerative diseases.
Director, Center for Applied NanoBioscience and Medicine, Interim Co-Chair, Basic Medical Sciences, Professor, BIO5 Institute, Professor, Basic Medical Sciences, Professor, Biomedical Engineering, Professor, Clinical Translational Sciences, Professor, Radiation Oncology
Our research approaches apply a combination of advances in nanoscience, molecular biology and omics to a new generation of biological tools and sensors based on nano and microscale technologies for breakthrough applications in healthcare delivery.
