Brian L Erstad

Brian L Erstad

Department Head, Pharmacy Practice-Science
Professor, Pharmaceutical Sciences
Member of the Graduate Faculty
Professor, BIO5 Institute
Primary Department
Contact
(520) 626-4289

Work Summary

Brian Erstad’s research interests pertain to critical care medicine with an emphasis on patient safety and related outcomes research.

Research Interest

Brian L. Erstad, PharmD, FCCM, is currently a tenured professor and head of the Department of Pharmacy Practice and Science. He is also a center investigator for the Center for Health Outcomes and PharmacoEconomics Research and a co-director for the Arizona Clinical and Translational Research Graduate Certificate Program. His clinical responsibilities are performed at Banner-University Medical Center Tucson.Dr. Erstad’s research interests pertain to critical care medicine with an emphasis on patient safety and related outcomes research. He has authored more than 150 peer-reviewed articles and book chapters.Dr. Erstad has served on the board of directors of the American Society of Health-System Pharmacists and on numerous committees and task forces for other organizations including AHRQ, USP, Society of Critical Care Medicine and the American College of Chest Physicians. He is currently an ad hoc member of the FDA’s Drug Safety and Risk Management Advisory Committee, a steering committee member of the United States Critical Illness and Injury Trials (USCIIT) Group, and treasurer of the American College of Clinical Pharmacy.

Publications

Pasero, C., Puntillo, K., Denise, L. i., Mularski, R. A., Grap, M. J., Erstad, B. L., Varkey, B., Gilbert, H. C., Medina, J., & Sessler, C. N. (2009). Structured approaches to pain management in the ICU. Chest, 135(6), 1665-1672.

PMID: 19497902;Abstract:

Pain in patients who are critically ill remains undertreated despite decades of research, guideline development and distribution, and intense educational efforts. By nature of their complex medical conditions, these patients present unique challenges to the delivery of optimal pain treatment. Outdated clinical practices and faulty systems, such as a formulary that allows dangerous prescriptions, present additional obstacles. A multidisciplinary and patient-centered continuous quality improvement process is essential to identifying barriers and implementing evidence-based solutions to the problem of undertreated pain in hospital ICUs. This article addresses barriers common to the ICU setting and presents a number of structured approaches that have been shown to be successful in improving pain treatment in patients who are critically ill. Copyright © 2009 American College of Chest Physicians.

Erstad, B. L., Haas, C. E., O'Keeffe, T., Hokula, C. A., Parrinello, K., & Theodorou, A. A. (2011). Interdisciplinary patient care in the intensive care unit: Focus on the pharmacist. Pharmacotherapy, 31(2), 128-137.

PMID: 21275491;Abstract:

The field of critical care medicine began to flourish only within the last 40 years, yet it provides some of the best examples of collaborative pharmacy practice models and evidence for the value of pharmacist involvement in interdisciplinary practice. This collaborative approach is fostered by critical care organizations that have elected pharmacists into leadership positions and recognized pharmacists through various honors. There is substantial literature to support the value of the critical care pharmacist as a member of an interdisciplinary intensive care unit (ICU) team, particularly in terms of patient safety. Furthermore, a number of economic investigations have demonstrated cost savings or cost avoidance with pharmacist involvement. As the published evidence supporting pharmacist involvement in patient care activities in the ICU setting has increased, surveys have demonstrated an increase in the percentage of pharmacists performing clinical activities. In addition, substantial support of pharmacists has been provided by other clinicians, safety officers, and administrative personnel who have been involved with the initiation and expansion of critical care pharmacy services in their own institutions. Although there is still room for improvement in the range of pharmacist involvement, particularly with respect to interdisciplinary activities related to education and scholarship, pharmacists have become essential members of interdisciplinary care teams in ICU settings.

Erstad, B. L., & Meeks, M. L. (1993). Influence of injection site and route on medication absorption. Hospital Pharmacy, 28(9), 853-856+858.

Abstract:

Concerns related to drug absorption are not limited to the oral route of administration. Medications given by various parenteral routes must also be absorbed to gain access to the systemic circulation. This article reviews the absorption characteristics of commonly administered medications by type and site of injection. The article focuses on four routes of parenteral injections: intramuscular, intralipomatous, subcutaneous, and intradermal. Differences in absorption relative to route or site of injection have been often demonstrated in studies, when such information was actively sought. Particularly important differences have been found with members of the following classes of medications: opiates, benzodiazepines, vaccines, insulins, and antiarrhythmics.

Erstad, B. L., & Favre, J. K. (1999). Written testing of students in the experiential setting. American Journal of Pharmaceutical Education, 63(4), 426-429.

Abstract:

There is a paucity of literature regarding specific evaluation or testing procedures used in the experiential setting. The purpose of this investigation was to compare the results of paired baseline and end-rotation short-answer tests and determine the potential role of such testing in the student learning and evaluation process. The preceptor had students on rotations at this site for approximately ten years, which resulted in 86 pre/post examinations. There was significant improvement in the scores from baseline to end-rotation (10.51 ± 2.90 to 13.92 ± 2.50, P0.001). Students expressed concerns that the evaluation exercise would be used for grading purposes despite assurances to the contrary. The preceptor was concerned that the examinations would not be useful in assessing higher level cognitive skills that were rotation objectives. Based on these findings, the written examination will be used as interactive assessment instrument, not as a replacement for more subjective grading tools.

Erstad, B. L., Martin, S. J., Brophy, G. M., Haas, C. E., Jacobi, J., Welage, L. S., & Thomas, M. C. (2005). Key articles and guidelines relative to intensive care unit pharmacology - 2004. Pharmacotherapy, 25(4), 585-610.

PMID: 15977919;Abstract:

Compilations of key articles and guidelines in a particular clinical practice area are useful not only to clinicians who practice in that area, but to all clinicians. We compiled pertinent articles and guidelines pertaining to drug therapy in the intensive care setting from the perspective of actively practicing critical care pharmacists. This document differs from the original 2002 version in that a broader assembly of intensive care practitioners was involved in the compilation.