Health
Professor, Pathology - (Research Scholar Track), Research Professor, BIO5 Institute
The personalized diagnosis and treatment of cancer.
Professor, BIO5 Institute, Professor, Immunobiology
Specialist
Associate Professor, American Indian Studies-GIDP, Associate Professor, BIO5 Institute, Associate Professor, Chemical and Environmental Engineering, Associate Professor, Public Health
Adjunct Associate Professor, Animal and Comparative Biomedical Sciences, Associate Research Scientist, BIO5 Institute, Director/Attending Veterinarian, University Animal Care, Veterinary Specialist
Director, Statistical Consulting, Professor, BIO5 Institute, Professor, Public Health, Professor, Statistics-GIDP
My research develops new clinical trial and experimental study designs to allow 'learning from data' more efficiently. My research also develops new analysis methods to understand latent structure in data. This allows better understanding of disease processes, better targeting of existing treatments, and development of more effective new treatments.
Director, Center for Innovation in Brain Science, Professor, BIO5 Institute, Professor, Clinical Translational Sciences, Professor, Evelyn F Mcknight Brain Institute, Professor, Neurology, Professor, Neuroscience - GIDP, Professor, Pharmacology, Professor, Pharmacology and Toxicology, Professor, Psychology
Professor, BIO5 Institute, Professor, Plant Science, Research Associate Professor, Entomology, Professor, Entomology / Insect Science - GIDP
Unravel the phylodynamics and transmission-specific determinants of emerging plant virus/fastidious bacteria-insect vector complexes, and translate new knowledge to abate pathogen spread in food systems.
Assistant Research Professor
Adjunct Professor, Mining and Geological Engineering, Associate Dean, Research-Public Health, Professor, BIO5 Institute, Professor, Public Health, Associate Dean, Research - Mel and Enid Zuckerman College of Public Health
Dean, Charles-Sander - College of Agriculture and Life Sciences, Director, Experiment Station, Professor, Animal and Comparative Biomedical Sciences, Professor, BIO5 Institute, Professor, Immunobiology, Vice President, Agriculture - Life and Veterinary Sciences / Cooperative Extension
Research Professor, Research Professor, BIO5 Institute
Peptides and proteins play a vital role in almost every cellular process in living organisms. Our research discovers and determines structural information on peptides and proteins to design drugs to more effectively treat human disease.
Associate Professor, BIO5 Institute, Associate Professor, Clinical Translational Sciences, Associate Professor, Otolaryngology, Vice Chair, Academic Affairs - Otolaryngology
Assistant Professor, BIO5 Institute, Associate Professor, Pharmacology and Toxicology
Department Chair, Epidemiology and Biostatistics, Distinguished Professor, Professor, Anthropology, Professor, BIO5 Institute, Professor, Statistics-GIDP
Associate Dean, Research and Graduate Studies - College of Pharmacy, Director, Southwest Environmental Health Science Center, Professor, BIO5 Institute, Professor, Clinical Translational Sciences, Professor, Pharmacology and Toxicology, Professor, Public Health
Division Chief, Infectious Disease, Professor, BIO5 Institute, Professor, Immunobiology, Professor, Medicine
Assistant Professor, BIO5 Institute, Assistant Professor, Physiological Sciences - GIDP, Associate Professor, Animal and Comparative Biomedical Sciences
We investigate how the chemicals in our daily lives interact with the female reproductive system and influence fertility. We hope that our discoveries will help reduce the incidence of infertility and improve women's health.
Director, Cutaneous Oncology Program, Professor, BIO5 Institute, Professor, Medicine - (Tenure Track)
Professor, BIO5 Institute, Professor, Neuroscience - GIDP, Professor, Pharmacology, Professor, Pharmacology and Toxicology, Professor, Physiological Sciences - GIDP
Professor, BIO5 Institute, Professor, Emergency Medicine, Professor, Optical Sciences
Head, Pharmacology and Toxicology, Professor, BIO5 Institute, Professor, Pharmacology and Toxicology
Xinxin Ding, PhD, department head, Pharmacology and Toxicology, College of Pharmacy—studies enzyme function, regulation and genetics as applied to translational research for drug safety and efficacy and genetic and environmental risks for chemical toxicity. Author of nearly 200 peer-reviewed papers, book chapters and articles, he serves as associate editor for “Drug Metabolism and Disposition” and “Acta Pharmaeutica Sinica B.” Grants from the National Cancer Institute and National Institute of Environmental Health Sciences of the National Institute of Health fund his work, in part. Former chair of the NIH XNDA study section (2016-2018), he currently chairs (2018-19) Drug Metabolism and Disposition Division of the American Society for Pharmacology and Experimental Therapeutics..
Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Cellular and Molecular Medicine, Professor, Genetics - GIDP
I am investigating a human connective tissue disorder in mice. I am also investigating the role of gut bacteria in colon cancer risk in both a mouse model of colon cancer and in humans with colon cancer.
Associate Professor, BIO5 Institute, Associate Professor, Immunobiology, Associate Professor, Neurology, Associate Professor, Neuroscience - GIDP, Associate Professor, Psychology, Research Scientist
Approximately 795,000 Americans suffer a stroke each year, and 400,000 will experience long-term disability. The number of stroke survivors in the population is expected to double by 2025. Currently, treatments for stroke patients are limited to tissue plasminogen activator (TPA), but its use is limited to the first few hours after stroke. Therefore, the goal of our research is to develop new therapeutics that can promote repair and recovery in this rapidly growing population.
Assistant Professor, BIO5 Institute, Assistant Professor, Gastrointestinal Microbiology, Assistant Professor, Physiological Sciences - GIDP
Department Head, Pharmacy Practice-Science, Professor, BIO5 Institute, Professor, Pharmaceutical Sciences
Brian Erstad’s research interests pertain to critical care medicine with an emphasis on patient safety and related outcomes research.
Clinical Instructor, Pharmacy Practice-Science, Professor, Medicine, Professor, BIO5 Institute, Professor, Nutritional Sciences
Janet Funk's work includes a focus on metastatic breast cancer that spans the research spectrum from bench to bedside, translational arthritis studies of the pharmacokinetics and safety of turmeric, and collaborative endocrinological studies evaluating the effects of obesity and insulin resistance on bone development in Hispanic girls, as well as effects of metformin on breast cancer risk on obese women.
Director, Valley Fever Center for Excellence, Professor, BIO5 Institute, Professor, Medicine
Valley Fever (coccidioidomycosis) occurs more in Arizona than anywhere else. My research and others at the Valley Fever Center for Excellence involve understanding how disease is caused by infection, how the immune system stops or prevents illness, and how we can better diagnose, treat, or prevent this public health problem.
Research Professor, Center for Toxicology, Research Professor, BIO5 Institute
Dr. Gandolfi directed toxicology research projects at the University of Arizona since 1978. His research interests are in the toxicity of halogenated hydrocarbons and metals with an emphasis on hepatic and renal systems. He was also active in developing in vitro toxicity models and the disposition of xenobiotics.
Senior Research Scientist, BIO5 Institute
Vijay Gokhale's work includes the use of medicinal chemistry in the development of small molecule therapeutics for neuropathic pain, idiopathic pulmonary fibrosis (IPF), and acute lung injury and cancer.
Assistant Director, Cancer Research, Assistant Professor, BIO5 Institute, Assistant Professor, Pharmacology, Assistant Professor, Public Health, Assistant Vice President, Translational Research in Special Populations, Associate Director, Center for Elimination of Border Health, Co-Director, Clinical Translational Sciences - Tucson, Director, BLAISER Program
Director, Epidemiology, Professor, BIO5 Institute, Professor, Medicine - (Tenure Track), Professor, Public Health, Research Scientist, Respiratory Sciences
Stefano Guerra's work includes an epidemiologic study, which used a household-based approach to assess prevalence and longitudinal changes in respiratory health. Other biomarker projects include a study on molecular biomarkers of asthma and COPD from the European Community Respiratory Health Survey.
Director, Natural Products Center, Professor, Arid Lands Resources Sciences - GIDP, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Natural Resources and the Environment, Professor, Pharmacology and Toxicology
Discovery of natural products from plants and their associated microorganisms as potential drugs to treat cancer. Application of medicinal chemistry approach for structure-activity relationship studies and to obtain compounds for preclinical evaluation. Development of alternative agricultural systems for sustainable utilization of natural resources.
Executive Director, AHSC Biorepository, Professor, BIO5 Institute, Professor, Immunobiology, Professor, Medicine, Professor, Applied BioSciences - GIDP
We are involved in banking clinical specimens obtained from various patients for use in biomarker discovery and clinical therapies. Clinical therapies may include regenerative medicine, transplant or gene therapy.
Associate Professor, BIO5 Institute, Associate Professor, Physiological Sciences - GIDP, Co-Chair, ABBS Program, Professor, Cellular and Molecular Medicine
The long-term goal of research in my lab is to understand the molecular mechanisms of muscle contraction. I am especially interested in how contractile proteins of muscle sarcomeres regulate the force and speed of contraction in the heart. The question is important from both basic science and clinical perspectives because mutations in sarcomere proteins of muscle are a leading cause of hypertrophic cardiomyopathy (HCM), the most common cause of sudden cardiac death in the young and a prevalent cause of heart failure in adults. Myosin binding protein-C (MyBP-C) is a muscle regulatory protein that speeds actomyosin cycling kinetics in response to adrenaline (b-adrenergic stimuli) and is one of the two most commonly affected proteins linked to HCM. Currently, the major research focus in my lab is understanding the mechanisms by which cMyBP-C regulates contractile speed and mechanisms by which mutations in cMyBP-C cause disease.
Professor, BIO5 Institute, Professor, Evelyn F Mcknight Brain Institute, Professor, Physiology, Professor, Psychology, Professor, Physiological Sciences - GIDP
Our lab is focused on the development of novel peptides to inhibit this inflammatory cascade and improve brain blood flow. These peptides are designed to significantly improve serum half-life and penetrate the blood-brain-barrier. These peptides act to inhibit the inflammatory pathways at both the level of brain blood vessels and the brain itself.
Associate Professor, BIO5 Institute, Associate Professor, Clinical Translational Sciences, Associate Professor, Medicine
Louise Hecker’s research is focused on understanding why the process of regenerative biology and mechanisms of tissue injury-repair "goes awry" in aging. She is working to identifying novel pathways that can be targeted to reverse age-associated diseases, such as Idiopathic pulmonary fibrosis (IPF).
Associate Professor, BIO5 Institute, Associate Professor, Basic Medical Sciences, Associate Professor, Clinical Translational Sciences, Associate Professor, Obstetrics and Gynecology
Professor, Applied BioSciences - GIDP, Professor, BIO5 Institute, Professor, Plant Sciences
My research is directed at producing enhanced traits in soybean that improves its use and sustainability to provide for growing global needs. In soybeans have produced enhanced seeds that contain much more protein content while minimizing or eliminating several food allergens and anti-nutritional proteins. This will provide better food and animal feed.
Associate Professor, BIO5 Institute, Associate Professor, Nutritional Sciences, Associate Professor, Public Health
Melanie Hingle's work focuses on understanding determinants of energy balance behaviors (i.e. how and why behaviors are initiated and sustained), and identifying contributors to the success of interventions (i.e. when, where, and how interventions should be delivered) are critical steps toward developing programs that effectively change behavior, thereby mitigating unhealthy weight gain and promoting optimal health. Current projects include: Determinants of metabolic risk, and amelioration of risk, in pediatric cancer survivors, Guided imagery intervention delivered via a mobile software application to increase healthy eating and physical activity in weight-concerned women smokers, and Family-focused diabetes prevention program delivered in partnership with the YMCA.
Associate Professor, Chemistry and Biochemistry - Med, Associate Professor, Chemistry and Biochemistry-Sci, Associate Professor, Genetics - GIDP, Associate Professor, Molecular and Cellular Biology
The Horton lab uses biophysical, biochemical, and molecular biology to study protein-DNA interactions and filament formation by enzymes. Current projects include the investigation of mechanisms of disease caused by the Human Parvovirus B19, and advantages of filament formation by enzymes such as the sequence specific DNA endonuclease SgrAI, and the important metabolic enzyme PFK.
Professor, BIO5 Institute, Professor, Pharmacology and Toxicology
The Hulme group is focused on small molecule drug design and developing enabling chemical methodologies to expedite the drug discovery process. The development of small molecule inhibitors of kinases is of particular interest.
Associate Professor, Research Scholar Track - Internal Medicine, Director, Clinical Outcomes Research
Professor, BIO5 Institute, Professor, Immunobiology, Professor, Medicine, Professor, Pathology, Professor, Pediatrics, Program Director, Blood and Bone Marrow Transplant, Professor, Cancer Biology - GIDP
Augmenting immune responses to cancer. Reducing relapse and graft versus host disease after hematopoietic cell transplantation.
Professor, Medical Imaging, Professor, Neurology, Professor, BIO5 Institute
Chelsea Kidwell specializes in prevention and treatment of stroke. She has special interests in medical imaging and stroke as well as ethnic and racial disparities among stroke patients.
Assistant Professor, BIO5 Institute, Assistant Professor, Cognitive Science - GIDP, Assistant Professor, Speech/Language and Hearing
My research examines neural factors which affect language functions, and how these change across life-span and are influenced by stroke, brain injury and neurodegenerative disorders. In my work, I use combination of cognitive measures and multimodal neuroimaging techniques (fMRI, EEG/ERPs, MEG). I am also interested in recovery of function, and treatment approaches involving speech-language therapy in combination with noninvasive brain stimulation techniques.
Assistant Professor, BIO5 Institute, Assistant Professor, Genetics - GIDP, Assistant Professor, Public Health
I use human genetic data to find associations of genetic markers with traits and diseases, to shed light on disease pathophysiology, causal pathways, and health disparities, and to inform personalized medicine.
Associate Professor, Associate Professor, BIO5 Institute, Associate Professor, Evelyn F Mcknight Brain Institute, Associate Professor, Immunobiology, Associate Professor, Neuroscience - GIDP
We study how a common intracellular parasite, Toxoplasma gondii, persists in, and potentially changes, the mammalian brain. Understanding the Toxoplasma-brain interaction offers the opportunity to develop better therapies to treat toxoplasmosis as well as giving new insights into how to manipulate the brain immune response which has been implicated in many neurodegenerative diseases.
Chair, Department of Medicine, Professor, BIO5 Institute, Professor, Medicine
Monica Kraft's research focus is in the areas of adult asthma, the role of infection in asthma and the role of the distal lung in asthma and airway remodeling.
Investigator, Center for Toxicology, Professor, BIO5 Institute, Professor, Cellular and Molecular Medicine, Professor, Public Health
We are interested in the effects of early life exposures to environmental toxicants on lung growth and development. We determine if the early life exposures leads to adult disease.
Assistant Professor, BIO5 Institute, Assistant Professor, Pharmacology
Associate Professor, Child Health - (Research Scholar Track)
Jonathan Lifshitz's research questions primarily investigate traumatic brain injury as a disease process that dismantles, repairs and regenerates circuits in the brain. The underlying principle is that adaptive repair and regeneration fail, leaving a miswired brain and neurological impairments that decrease quality of life.
Assistant Dean, Graduate Education, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Nutritional Sciences, Professor, Physiological Sciences - GIDP
Kirsten Limesand's research program has its foundation in radiation-induced salivary gland dysfunction; mechanisms of damage, clinical prevention measures, and restoration therapies. They utilize a number of techniques including: genetically engineered mouse models, real-time RT/PCR, immunoblotting, immunohistochemistry, primary cultures, siRNA transfections, and procedures to quantitate salivary gland physiology and integrate this information in order to understand the complete system.
Assistant Professor, BIO5 Institute, Assistant Professor, Pharmaceutical Sciences
Associate Director, Informatics, Associate Director, Cancer Informatics / Precision Health - UA Cancer Center, Associate Vice President / Chief Knowledge Officer, UA - Health Sciences Center, Professor, Clinical Translational Sciences, Professor, Medicine - (Tenure Track), Professor, Statistics-GIDP
Associate Professor, Cellular and Molecular Medicine, Associate Professor, BIO5 Institute, Associate Professor, Immunobiology
Associate Professor, Medicine, Associate Professor, Public Health
Adjunct Professor, Pharmacology and Toxicology
Associate Professor, BIO5 Institute, Associate Professor, Clinical Translational Sciences, Associate Professor, Medicine, Associate Professor, Pharmaceutical Sciences
Director, Asthma / Airway Disease Research Center, Endowed Chair, Swift - McNear, Professor, BIO5 Institute, Professor, Pediatrics, Regents Professor, Professor, Genetics - GIDP
Assistant Professor, Cancer Biology - GIDP, Assistant Professor, Cellular and Molecular Medicine, Assistant Professor, Genetics - GIDP, Research Associate Professor, Medicine
Director, Cyber Innovation, Director, Data Science Institute
Associate Professor, BIO5 Institute, Associate Professor, Chemistry and Biochemistry-Sci
We seek to produce new drugs that harness molecules produced during the natural immune response in order to treat cancer and pain. Such compounds may also provide new treatments for heart failure and alcoholism.
Co-Program Leader, Cancer Biology Research Program, Professor, BIO5 Institute, Professor, Cellular and Molecular Medicine
Co-Director, Arizona Center on Aging, Department Head, Immunobiology, Professor, BIO5 Institute, Professor, Immunobiology, Professor, Medicine, Professor, Nutritional Sciences, Professor, Genetics - GIDP, Professor, Neuroscience - GIDP
Associate Professor, Medicine, Professor, Pharmacy Practice-Science
Associate Vice President, Clinical Research / Global Health Initiatives, Professor, BIO5 Institute, Professor, Medicine, Professor, Mel and Enid Zuckerman College of Public Health
Professor, Animal and Comparative Biomedical Sciences, Professor, BIO5 Institute, Professor, Medical Imaging - (Research Scholar Track), Professor, Physiological Sciences - GIDP, Professor, Surgery
Assistant Professor, BIO5 Institute, Assistant Professor, Public Health, Associate Veterinary Specialist, Animal and Comparative Biomedical Sciences
Assistant Professor, Medicine, Assistant Research Scientist
Endowed Chair, Thomas R Brown - Biomedical Engineering, Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Electrical and Computer Engineering
Our group develops rapid, inexpensive tools for the immediate discovery and identification of infectious diseases. It is critical for highly populated areas and resource-poor environments to have access to immediate therapeutics to save their populations and prevent the spread of these diseases.
Associate Vice President, Precision Health Sciences, Associate Vice President, Research, Director, MD/PhD Program, Professor, Internal Medicine, Professor, Medicine
Professor, Neurology, Professor, Psychology, Professor, Speech/Language and Hearing, Professor, BIO5 Institute
Associate Professor, Animal and Comparative Biomedical Sciences, Associate Professor, BIO5 Institute
Associate Professor, Animal and Comparative Biomedical Sciences, Associate Professor, BIO5 Institute, Associate Professor, Nutritional Sciences, Associate Professor, Physiological Sciences - GIDP
Renquist Lab Research aims to address the causes and consequent diseases of obesity. To this end we have research focused on 1) type 2 diabetes and obesity associated hypertension, 2) development of effective, ligand-directed, chemotherapeutic for cancer, and 3) central nervous system control of visceral blood flow and food intake.
Research Scholar
Associate, Center for Toxicology, Professor, Animal and Comparative Biomedical Sciences, Professor, BIO5 Institute, Professor, Nutritional Sciences, Professor, Cancer Biology - GIDP
Assistant Professor, Cellular and Molecular Medicine, Research Fellow, BIO5 Institute
My laboratory aims to identify the genetic and environmental reasons that certain individuals are predisposed to develop complex diseases like heart disease. We use new technologies, experimental, and computational approaches to identify molecular patterns indicative of disease predisposition.
Professor, BIO5 Institute, Professor, Medicine
Associate Professor, Nutritional Sciences
Associate Professor, BIO5 Institute, Associate Professor, Ecology and Evolutionary Biology, Associate Professor, Entomology, Associate Professor, Entomology / Insect Science - GIDP, Associate Professor, Genetics - GIDP, Associate Professor, Molecular and Cellular Biology, Associate Professor, Neuroscience - GIDP
Associate Professor, Applied BioSciences - GIDP, Associate Professor, BIO5 Institute, Associate Professor, Pathology - (Research Scholar Track)
We are studying how tumor cells escape immunosurveillance, a hallmark of cancer, in aggressive lymphomas. MHCII is a protein important for immunosurveillance. We are studying the underlying mechanisms of altered regulation of MHCII in lymphoma cells and its effects on tumor immunosurveillance.
Assistant Professor, Applied BioSciences - GIDP, Assistant Professor, Genetics - GIDP, Associate Professor, Plant Science
My research focus is on functional foods—designing crops to deliver more than mere calories—by both adding nutritional compounds and eliminating anti-nutritional compounds. I work on enhancing seeds of two of the most globally important crops, soybean and corn.
Professor, Applied Mathematics - GIDP, Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Mathematics, Professor, Physiological Sciences - GIDP, Professor, Physiology, Research Professor, Arizona Research Labs
Director, Research - Arizona Center for Integrative Medicine, Professor, BIO5 Institute, Professor, Medicine - (Research Scholar Track), Professor, Psychology
Assistant Professor, BIO5 Institute, Assistant Professor, Biomedical Engineering, Assistant Professor, Clinical Translational Sciences, Assistant Professor, Statistics-GIDP, Assistant Professor, Systems and Industrial Engineering
Adjunct Associate Professor, Aerospace-Mechanical Engineering, Adjunct Associate Professor, Materials Science and Engineering, Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Orthopaedic Surgery, Professor, Physiological Sciences - GIDP
Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Cellular and Molecular Medicine, Professor, Medicine, Professor, Physiological Sciences - GIDP
Assistant Professor, Neuroscience - GIDP, Assistant Professor, Physiological Sciences - GIDP, Associate Professor
Director, Canyon Ranch Center for Prevention and Health Promotion, Distinguished Professor, Professor, BIO5 Institute, Professor, Clinical Translational Sciences, Professor, Medicine, Professor, Nutritional Sciences Graduate Program, Professor, Public Health
Professor, Biomedical Engineering
Professor, Animal and Comparative Biomedical Sciences, Professor, BIO5 Institute, Professor, Immunobiology
Our research efforts focus on bacteria that cause serious healthcare-associated infections, and those associated with antibiotic use. This infections disproportiOur federally-funded research focuses on infection prevention. Specifically, we study diseases such as Clostridium difficile Infection that affect populations worldwide ("One-Health" issue). Our current efforts are aimed at translating bench-research findings to the bedside. We have recently been awarded two patents for a novel biologic agent invention aimed at preventing bacterial infections in humans as well as food animals.onately affect the elderly, and those with compromised immune systems. One overarching goal of our studies is to develop safe, cost-effective, non-antibiotic interventions to prevent and treat bacterial diarrheas.
Associate Professor, Animal and Comparative Biomedical Sciences, Associate Professor, BIO5 Institute
Ninety children die every hour due to diarrhea. My laboratory uses the latest technology to understand how bacteria cause diarrhea in children. In addition to providing clues for new ways to prevent disease, our research helps us understand how the body maintains good health.
Associate Professor, Applied Mathematics - GIDP, Associate Professor, BIO5 Institute, Associate Professor, Biomedical Engineering, Associate Professor, Neuroscience - GIDP, Associate Professor, Optical Sciences, Professor, Medical Imaging
We develop cutting-edge imaging technology, integrating light, ultrasound and electricity, to diagnose and treat diseases ranging from epilepsy to breast cancer. Novel sources for ultrasound contrast include optical and microwave absorption, mechanical strain, and electrical current. We visualize electrical brain “stormsˮ during uncontrollable seizures and envision “smartˮ photoacoustic agents that seek-and-destroy deadly tumors.
Professor, BIO5 Institute, Professor, Pharmacology and Toxicology, Professor, Cancer Biology - GIDP
Professor, Agricultural-Biosystems Engineering, Professor, Animal and Comparative Biomedical Sciences, Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Chemistry and Biochemistry-Sci
Professor, Applied BioSciences - GIDP, Professor, BIO5 Institute, Professor, Cellular and Molecular Medicine, Professor, Genetics - GIDP, Professor, Molecular and Cellular Biology, Professor, Neurology, Professor, Neuroscience, Professor, Neuroscience - GIDP
We are working to uncover the molecular mechanisms of aging and neurodegenerative diseases using a combination of genetic, computational and pharmacological tools, and a diverse array of experimental models. We also seek to develop therapies for ALS and related neurodegenerative diseases.