Abstract:
In epidemiology, contact tracing is a process to control the spread of an infectious disease and identify individuals who were previously exposed to patients with the disease. After the emergence of AIDS, Social Network Analysis (SNA) was demonstrated to be a good supplementary tool for contact tracing. Traditionally, social networks for disease investigations are constructed only with personal contacts. However, for diseases which transmit not only through personal contacts, incorporating geographical contacts into SNA has been demonstrated to reveal potential contacts among patients. In this research, we use Taiwan SARS data to investigate the differences in connectivity between personal and geographical contacts in the construction of social networks for these diseases. According to our results, geographical contacts, which increase the average degree of nodes from 0 to 108.62 and decrease the number of components from 961 to 82, provide much higher connectivity than personal contacts. Therefore, including geographical contacts is important to understand the underlying context of the transmission of these diseases. We further explore the differences in network topology between one-mode networks with only patients and multi-mode networks with patients and geographical locations for disease investigation. We find that including geographical locations as nodes in a social network provides a good way to see the role that those locations play in the disease transmission and reveal potential bridges among those geographical locations and households. © Springer-Verlag Berlin Heidelberg 2007.
Abstract:
Ever since the 9-11 incident, the multidisciplinary field of terrorism has experienced tremendous growth. As the domain has benefited greatly from recent advances in information technologies, more complex and challenging new issues have emerged from numerous counter-terrorism-related research communities as well as governments of all levels. In this paper, we describe an advanced knowledge discovery approach to addressing terrorism threats. We experimented with our approach in a project called Terrorism Knowledge Discovery Project that consists of several custom-built knowledge portals. The main focus of this project is to provide advanced methodologies for analyzing terrorism research, terrorists, and the terrorized groups (victims). Once completed, the system can also become a major learning resource and tool that the general community can use to heighten their awareness and understanding of global terrorism phenomenon, to learn how best they can respond to terrorism and, eventually, to garner significant grass root support for the government's efforts to keep America safe. © Springer-Verlag Berlin Heidelberg 2004.
Abstract:
Predicting blood concentration levels of pharmaceutical agents in human subjects can be made difficult by missing data and variability within and between human subjects. Biometricians use a variety of software tools to analyze pharmacokinetic information in order to conduct research about a pharmaceutical agent. This paper is the comparison between using a feedforward backpropagation neural network to predict blood serum concentration levels of the drug tobramycin in pediatric cystic fibrosis and hemotologic-oncologic disorder patients with the most commonly used software for analysis of pharmacokinetics, NONMEM. Mean squared standard error is used to establish the comparability of the two estimation methods. The motivation for this research is the desire to provide clinicians and pharmaceutical researchers a cost effective, user friendly, and timely analysis tool for effectively predicting blood concentration ranges in human subjects.
Abstract:
Link (association) analysis has been used in law enforcement and intelligence domains to extract and search associations between people from large datasets. Nonetheless, link analysis still faces many challenging problems, such as information overload, high search complexity, and heavy reliance on domain knowledge. To address these challenges and enable crime investigators to conduct automated, effective, and efficient link analysis, we proposed three techniques which include: the concept space approach, a shortest-path algorithm, and a heuristic approach that captures domain knowledge for determining importance of associations. We implemented a system called CrimeLink Explorer based on the proposed techniques. Results from our user study involving ten crime investigators from the Tucson Police Department showed that our system could help subjects conduct link analysis more efficiently. Additionally, subjects concluded that association paths found based on the heuristic approach were more accurate than those found based on the concept space approach. © Springer-Verlag Berlin Heidelberg 2003.
