Senescence

Associate, Center for Toxicology, Director, Pharmacogenomics, Endowed Professor, Holslaw - Pharmacogenomics, Member of the Graduate Faculty, Professor, Applied BioSciences - GIDP, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Genetics - GIDP, Professor, Pharmacogenomics, Professor, Pharmacology, Professor, Pharmacology and Toxicology
Department Chair, Epidemiology and Biostatistics, Distinguished Professor, Public Health, Professor, Anthropology, Professor, BIO5 Institute, Professor, Public Health, Professor, Statistics-GIDP
Professor, BIO5 Institute, Professor, Medicine - (Research Scholar Track), Research Scientist
Our lab has a new treatment for heart failure. We have a biodegradable graft seeded with adult human cells that we put on the surface of the heart. The potential is to regenerate new heart muscle
Associate Director, BIO5 Institute, Professor, BIO5 Institute, Professor, Medicinal Chemistry-Pharmaceutical Sciences, Professor, Medicinal Chemistry-Pharmacology and Toxicology, Professor, Cancer Biology - GIDP
Laurence Hurley's long-time research interest is in molecular targeting of DNA, first by covalent binders (CC-1065 and psorospermin), then as compounds that target protein–DNA complexes (pluramycins and Et 743), and most recently as four-stranded DNA structures (G-quadruplexes and i-motifs). He was the first to show that targeting G-quadruplexes could inhibit telomerase (Sun et al. [1997] J. Med. Chem., 40, 2113) and that targeting G-quadruplexes in promoter complexes results in inhibition of transcription (Siddiqui-Jain et al. [2002] Proc. Natl. Acad. Sci. U.S.A., 99, 11593).
Assistant Professor, Assistant Professor, BIO5 Institute, Assistant Professor, Cancer Biology - GIDP, Assistant Professor, Genetics - GIDP, Assistant Professor, Molecular and Cellular Biology, Member of the Graduate Faculty
The Sutphin Lab studies the molecular basis of aging. Individual age is the primary risk factor for the majority of the top causes of death in the United States and other developed nations. As our population grows older, aging is increasingly a central problem for both individual quality of life and the economics of societal health. Understanding the molecular architecture that drives aging will reveal key intervention points to extend healthy human lifespan, simultaneously delay onset of multiple categories of age-associated disease, and develop targeted treatments for specific pathologies. We use a combination of systems biology, comparative genetics, and molecular physiology to identify new genetic and environmental factors in aging and characterize their molecular role in age-associated disease.
Member of the Graduate Faculty, Professor, Applied BioSciences - GIDP, Professor, BIO5 Institute, Professor, Cellular and Molecular Medicine, Professor, Genetics - GIDP, Professor, Molecular and Cellular Biology, Professor, Neurology, Professor, Neuroscience, Professor, Neuroscience - GIDP
We are working to uncover the molecular mechanisms of aging and neurodegenerative diseases using a combination of genetic, computational and pharmacological tools, and a diverse array of experimental models. We also seek to develop therapies for ALS and related neurodegenerative diseases.
Professor, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP