Associate, Center for Toxicology, Professor, Pharmacology, Professor, Pharmacology and Toxicology, Professor, Applied BioSciences - GIDP, Professor, Cancer Biology - GIDP
Professor, BIO5 Institute, Professor, Neuroscience - GIDP, Professor, Pharmacology, Professor, Pharmacology and Toxicology, Professor, Physiological Sciences - GIDP
Professor, Anesthesiology, Professor, BIO5 Institute, Professor, Neuroscience - GIDP, Professor, Pharmacology
The focus of my laboratory’s’ research is to understand how ion channels, specifically, voltage-gated calcium and sodium channels, are regulated by novel protein interactions. Recent studies in my laboratory have focused on targeting protein-protein interactions with biologics (peptide aptamers) and small molecules; testing the activity of these novel chemical entities in biochemical and immunofluorescent-based assays of trafficking; examining their protein interaction signatures; testing them with whole cell voltage-clamp electrophysiology and voltage- and calcium sensitive fluorescence-based imaging. Regulating these protein networks to modulate the activity of ion channels in neurodegenerative diseases (Chronic Pain, Migraine, and Neurofibromatosis) is a key focus of the laboratory.