Gunaherath, G. B., Gunatilaka, A., Sultanbawa, M. S., & Balasubramaniam, S. (1983). 1,2(3)-Tetrahydro-3,3′-biplumbagin: A naphthalenone and other constituents from Plumbago zeylanica. Phytochemistry, 22(5), 1245-1247.
Abstract:
The isolation of plumbagin, droserone, isoshinanolone and a new naphthalenone, 1,2(3)-tetrahydro-3,3′-biplumbagin is reported from the phenolic fract. © 1983.
Subramanian, B., Nakeff, A., Tenney, K., Crews, P., Gunatilaka, L., & Valeriote, F. (2006). A new paradigm for the development of anticancer agents from natural products. Journal of Experimental Therapeutics and Oncology, 5(3), 195-204.
PMID: 16528970;PMCID: PMC1693669;Abstract:
A novel pharmacology paradigm has been developed which quickly and efficiently moves prospective anticancer drugs from the discovery phase through pharmacology testing and into therapeutic trial assessment. Following discovery, the drug is first assessed in a clonogenic assay which determines the cytotoxic effect of different concentrations of the drug at 3 different exposure durations: 2h, 24h and continuous (168 h). Second, pharmacokinetic information is obtained in both plasma and tumor for the drug administered at the maximum tolerated dose given intravenously. The first study defines the time-concentration profile required to obtain a specific cell survival for the tumor cells; the second study determines the concentration-time profile that can be obtained in both plasma and tumor at the maximum tolerated dose of the drug. The integration of this information determines whether a successful therapeutic trial is possible. Only when a drug shows therapeutic efficacy is a proteomics-based mechanism of action study initiated. Two drugs have been assessed in this paradigm: salicortin and fascaplysin A. © 2006 Old City Publishing, Inc.
Zhan, J., Kamal, G., Wijeratne, E. K., & Gunatilaka, A. L. (2007). Asperpyrone D and other metabolites of the plant-associated fungal strain Aspergillus tubingensis. Phytochemistry, 68(3), 368-372.
PMID: 17150233;PMCID: PMC3361907;Abstract:
Bioactivity-guided fractionation of a cytotoxic extract of Aspergillus tubingensis, a fungal strain occurring in the rhizosphere of the Sonoran desert plant, Fallugia paradoxa, afforded a dimeric naphtho-γ-pyrone asperpyrone D, nine known naphtho-γ-pyrones, funalenone, and the cytotoxic cyclic penta-peptide, malformin A1. © 2006 Elsevier Ltd. All rights reserved.
Gunatilaka, L., Xu, Y., Wijeratne, K., Brooks, A. D., Henrich, C. J., Tewary, P., & Sayers, T. J. (2017). 17beta-Hydroxywithanolides as Sensitizers of Renal Carcinoma Cells to TRAIL–Induced Apoptosis: Structure–Activity Relationships. Journal of Medicinal Chemistry, 60, 3039-3051. doi:10.1021/acs.jmedchem.7b00069
Gunatilaka, A., Silva, A. D., Sotheeswaran, S., & Tillekeratne, L. M. (1982). Horsfieldin, a lignan and other constituents from Horsfieldia iryaghedhi. Phytochemistry, 21(11), 2719-2723.
Abstract:
A new lignan, horsfieldin [2-(3-hydroxy-4-methoxyphenyl)-6-(3,4-methylenedioxyphenyl)-3,7-dioxabicyclo(3,3,0)octane], d-asarinin, (-)-dihydrocubebin, dodecanoylphloroglucinol, myristic acid, trimyristin and sitosterol have been isolated and characterized from the hot methanol extract of Horsfieldia iryaghedhi seeds. The absolute configuration of the lignans and the chemotaxonomic significance of their occurrence is discussed. © 1982.