John JB Allen

John JB Allen

Professor, Psychology
Distinguished Professor
Professor, BIO5 Institute
Member of the General Faculty
Professor, Neuroscience - GIDP
Member of the General Faculty
Member of the Graduate Faculty
Primary Department
Department Affiliations
Contact
(520) 621-7448

Work Summary

Depression is a major health problem that is often chronic or recurrent. Existing treatments have limited effectiveness, and are provided wihtout a clear indication that they will match a particular patient's needs. In this era of precision medicine, we strive to develop neurally-informed treatments for depression and related disorders.

Research Interest

Dr. Allen’s research spans several areas, but the main focus is the etiology and treatment of mood and anxiety disorders. His work focuses on identifying risk factors for depression using electroencephalographic and autonomic psychophysiological measures, especially EEG asymmetry, resting state fMRI connectivity, and cardiac vagal control. Based on these findings, he is developing novel and neurally-informed treatments for mood and anxiety disorders, including Transcranial Ultrasound, EEG biofeedback, and Transcranial Direct Current and Transcranial Alternating Current stimulation. Other work includes understanding how emotion and emotional disorders influence the way we make decisions and monitor our actions. Keywords: Depression, Neuromodulation, EEG, Resting-state fMRI

Publications

Accortt, E. E., Bismark, A., Schneider, T. R., & J., J. (2011). Diagnosing premenstrual dysphoric disorder: The reliability of a structured clinical interview. Archives of Women's Mental Health, 14(3), 265-267.

PMID: 21336934;Abstract:

Premenstrual dysphoric disorder (PMDD), a diagnosis included for further study in the DSM-IV-TR (American Psychiatric Association 2000), lacks a structured interview. The reliability of a Structured Clinical Interview for DSM-IV-TR-Defined PMDD (SCID-PMDD) was assessed with 96 participants who spanned the full range of premenstrual problems. All individual SCID-PMDD items had high inter-rater agreement, and the overall reliability of diagnosis was high (kappa=0.96). The SCID-PMDD provides a structured, sensitive, and reliable measure of the symptoms and impairment criteria for PMDD. © 2011 Springer-Verlag.

Allen, J. J., Iacono, W. G., Laravuso, J. J., & Dunn, L. A. (1995). An Event-Related Potential Investigation of Posthypnotic Recognition Amnesia. Journal of Abnormal Psychology, 104(3), 421-430.

PMID: 7673565;Abstract:

Forty-two individuals selected for high hypnotizability or for low hypnotizability were taught lists of words during hypnosis and assessed for recognition following hypnosis using event-related potential (ERP) procedures, both before and after the cue to reverse amnesia. A subgroup of low-hypnotizable participants were asked to simulate hypnotic behavior. All participants had larger late positive component (LPC) amplitudes to learned than to unlearned words, regardless of whether amnesia was reported. The highly hypnotizable participants who reported recognition amnesia, however, had significant changes in attention-related (P1 and N1) and recognition-related (N400 and LPC) ERP component amplitudes as a function of whether amnesia was reported. These data suggest that posthypnotic amnesia may involve alterations in the processes of attention, selection, and accessibility. © 1995 American Psychological Association.

Allen, J., Bismark, A. W., Hajcak, G., Whitworth, N. M., & Allen, J. J. (2013). The role of outcome expectations in the generation of the feedback-related negativity. Psychophysiology, 50(2).

The feedback-related negativity (FRN) is thought to index activity within the midbrain dopaminergic reward-learning system, with larger FRN magnitudes observed when outcomes are worse than expected. This view holds that the FRN is an index of neural activity coding for prediction errors, and reflects activity that can be used to adaptively alter future performance. Untested to date, however, is a key prediction of this view: the FRN should not appear in response to negative outcomes when outcome expectations are not allowed to develop. The current study tests this assumption by eliciting FRNs to win and loss feedback in conditions of participant choice, participant observation of computer choice, and, critically, simple presentation of win or loss feedback in the absence of a predictive choice cue. Whereas FRNs were observed in each of the conditions in which there was time for an expectation to develop, no FRN was observed in conditions without sufficient time for the development of an expectation. These results provide empirical support for an untested but central tenet of the reinforcement learning account of the genesis of the FRN.

Bourassa, K. J., Allen, J. J., Mehl, M. R., & Sbarra, D. A. (2017). Impact of Narrative Expressive Writing on Heart Rate, Heart Rate Variability, and Blood Pressure After Marital Separation. Psychosomatic medicine, 79(6), 697--705.
J., J., & Dveirin, K. (2003). Mechanism of wart disappearance: An alternative hypothesis. Archives of Pediatrics and Adolescent Medicine, 157(5), 490-.