Professor, BIO5 Institute, Professor, Genetics - GIDP, Professor, Immunobiology, Professor, Plant Sciences, Professor, Applied BioSciences - GIDP
Upon infection, viruses must transport their genomes into cells and produce progeny, often under a strict time deadline. We study how the viral proteins interact with with each other and with host cell proteins to efficiently accomplish these processes.
Director, Graduate Program in Immunobiology, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Cellular and Molecular Medicine, Professor, Genetics - GIDP, Professor, Immunobiology, Professor, Molecular and Cellular Biology
Dr. Goodrum's long-standing research focus is to understand the molecular virus-host interactions important to human cytomegalovirus (CMV) latency and persistence in the host. She has focused on identifying viral and host determinants mediating the switch between latent and replicative states. The goal of her research program is to define the mechanistic underpinnings of HCMV latency and reactivation to lay the foundation for clinical interventions to control CMV disease in all settings.
Associate Professor, Chemistry and Biochemistry - Med, Associate Professor, Chemistry and Biochemistry-Sci, Associate Professor, Genetics - GIDP, Associate Professor, Molecular and Cellular Biology
The Horton lab uses biophysical, biochemical, and molecular biology to study protein-DNA interactions and filament formation by enzymes. Current projects include the investigation of mechanisms of disease caused by the Human Parvovirus B19, and advantages of filament formation by enzymes such as the sequence specific DNA endonuclease SgrAI, and the important metabolic enzyme PFK.