Pinart, M., Albang, R., Maier, D., Duran-Tauleria, E., Mena, G., Gimeno-Santos, E., Solà, I., Garcia-Aymerich, J., Guerra, S., Stein, R. T., Benet, M., Carlsen, K., Herr, M., Jacquemin, B., Momas, I., Pin, I., Rancière, F., Smit, H. A., Varraso, R., , Bonfill, X., et al. (2015). Systematic Review on the Definition of Allergic Diseases in Children: The MeDALL Study. International archives of allergy and immunology, 168(2), 110-21.
During the last decades, a large number of phenotypes and disease classifications of allergic diseases have been proposed. Despite the heterogeneity across studies, no systematic review has been conducted on phenotype classification and the criteria that define allergic diseases. We aimed to identify clinically expressed, population-based phenotypes of allergic diseases and their interrelationships, to explore disease heterogeneity and to evaluate the measurements employed in disease diagnosis.
Vasquez, M., others, ., & Guerra, S. (2016). Low lung function in young adult life is associated with early mortality. The American Journal of Respiratory and Critical Care Medicine.
BIO5 Collaborators
Stefano Guerra, Chengcheng Hu
Ramon, M. A., Ferrer, J., Gimeno-Santos, E., Donaire-Gonzalez, D., Rodríguez, E., Balcells, E., de Batlle, J., Benet, M., Guerra, S., Sauleda, J., Ferrer, A., Farrero, E., Gea, J., Barberà, J. A., Agustí, A., Rodriguez-Roisin, R., Antó, J. M., Garcia-Aymerich, J., & , P. S. (2016). Inspiratory capacity-to-total lung capacity ratio and dyspnoea predict exercise capacity decline in COPD. Respirology (Carlton, Vic.), 21(3), 476-82.
Exercise capacity decline is a predictor of mortality in patients with chronic obstructive pulmonary disease (COPD). Static pulmonary hyperinflation is a key determinant of exercise performance, but its effect on the longitudinal decline in exercise capacity remains unknown. We aimed to study the relationship between the inspiratory capacity-to-total lung capacity (IC/TLC) ratio and exercise capacity decline in COPD.
Amaral, A. F., Minelli, C., Guerra, S., Wjst, M., Probst-Hensch, N., Pin, I., Svanes, C., Janson, C., Heinrich, J., & Jarvis, D. L. (2015). The locus C11orf30 increases susceptibility to poly-sensitization. Allergy, 70(3), 328-33.
A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly-sensitization is unknown. Using data from the large multicentre population-based European Community Respiratory Health Survey, we assessed the association between 10 loci and specific IgE and skin prick tests to individual allergens and poly-sensitization. We found that the 10 loci associate with sensitization to different allergens in a nonspecific manner and that one in particular, C11orf30-rs2155219, doubles the risk of poly-sensitization (specific IgE/4 allergens: OR = 1.81, 95% CI 0.80-4.24; skin prick test/4+ allergens: OR = 2.27, 95% CI 1.34-3.95). The association of rs2155219 with higher levels of expression of C11orf30, which may be involved in transcription repression of interferon-stimulated genes, and its association with sensitization to multiple allergens suggest that this locus is highly relevant for atopy.
Zhai, J., Stern, D., Sherrill, D., Spangenberg, A., Wright, A., Morgan, W., Halonen, M., Martinez, F., & Guerra, S. (2017). Trajectories and early determinants of circulating CC16 from birth to age 32 years. American Journal of Respiratory and Critical Care Medicine.
