Croteau-Chonka, D. C., Qiu, W., Martinez, F. D., Strunk, R. C., Lemanske, R. F., Liu, A. H., Gilliland, F. D., Millstein, J., Gauderman, W. J., Ober, C., Krishnan, J. A., White, S. R., Naureckas, E. T., Nicolae, D. L., Barnes, K. C., London, S. J., Barraza-Villarreal, A., Carey, V. J., Weiss, S. T., , Raby, B. A., et al. (2017). Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control. American journal of respiratory and critical care medicine, 195(2), 179-188.
Maintaining optimal symptom control remains the primary objective of asthma treatment. Better understanding of the biologic underpinnings of asthma control may lead to the development of improved clinical and pharmaceutical approaches.
von Mutius, E., & Martinez, F. D. (2016). Inconclusive Results of Randomized Trials of Prenatal Vitamin D for Asthma Prevention in Offspring: Curbing the Enthusiasm. JAMA, 315(4), 347-8.
Martinez, F. D. (2016). Safety of Fluticasone plus Salmeterol in Asthma--Reassuring Data, but No Final Answer. The New England journal of medicine, 374(19), 1887-8.
Bacharier, L. B., Guilbert, T. W., Mauger, D. T., Boehmer, S., Beigelman, A., Fitzpatrick, A. M., Jackson, D. J., Baxi, S. N., Benson, M., Burnham, C. A., Cabana, M., Castro, M., Chmiel, J. F., Covar, R., Daines, M., Gaffin, J. M., Gentile, D. A., Holguin, F., Israel, E., , Kelly, H. W., et al. (2015). Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses: A Randomized Clinical Trial. JAMA, 314(19), 2034-44.
Many preschool children develop recurrent, severe episodes of lower respiratory tract illness (LRTI). Although viral infections are often present, bacteria may also contribute to illness pathogenesis. Strategies that effectively attenuate such episodes are needed.
Fitzpatrick, A. M., Jackson, D. J., Mauger, D. T., Boehmer, S. J., Phipatanakul, W., Sheehan, W. J., Moy, J. N., Paul, I. M., Bacharier, L. B., Cabana, M. D., Covar, R., Holguin, F., Lemanske, R. F., Martinez, F. D., Pongracic, J. A., Beigelman, A., Baxi, S. N., Benson, M., Blake, K., , Chmiel, J. F., et al. (2016). Individualized therapy for persistent asthma in young children. The Journal of allergy and clinical immunology, 138(6), 1608-1618.e12.
Phenotypic presentations in young children with asthma are varied and might contribute to differential responses to asthma controller medications.