Molecular biology

Associate Dean, Research-Agriculture and Life Sciences, Associate Vice President for Research, Agriculture - Life and Veterinary Sciences / Cooperative Extension, Professor, Cellular and Molecular Medicine, Professor, Molecular and Cellular Biology, Professor, BIO5 Institute
Professor, Chemistry and Biochemistry-Sci, Professor, Chemistry and Biochemistry - Med, Professor, Biomedical Engineering, Department Head, Member of the Graduate Faculty, Professor, BIO5 Institute
Associate Professor, Molecular and Cellular Biology, Associate Professor, BIO5 Institute

The Buchan lab studies how cells regulate gene expression at the level of cytoplasmic messenger RNA (mRNA), the templates of protein synthesis. Areas of particular interest include mRNA-protein bodies called stress granules and P-bodies, which regulate mRNA function, cell signaling, and are implicated in the pathology of viral replication, various cancers and neurodegenerative diseases such as ALS.

Research Professor, Member of the General Faculty , Member of the Graduate Faculty, Research Professor, BIO5 Institute

Peptides and proteins play a vital role in almost every cellular process in living organisms. Our research discovers and determines structural information on peptides and proteins to design drugs to more effectively treat human disease.

Associate Professor, Chemistry and Biochemistry-Sci, Associate Professor, BIO5 Institute
Professor, Chemistry and Biochemistry-Sci, Professor, BIO5 Institute

The broad objective of our research program in Bioorganic Chemistry and Chemical Biology is to construct protein therapeutics, protein mimetics, biomaterials, and biosensors. Our research at the University of Arizona is highly multidisciplinary and utilizes techniques in organic synthesis, biochemistry, molecular biology, and a host of physical characterization methods. Our research motto is simple: Unraveling mysteries and Enabling discoveries.

Professor, Cellular and Molecular Medicine, Professor, Molecular and Cellular Biology, Professor, Biomedical Engineering, Professor, Genetics - GIDP, Professor, Physiological Sciences - GIDP, Professor, Physiology, Professor, BIO5 Institute

Our research is focused on elucidating the structure and function of titin and nebulin, two large filamentous proteins found in muscle. We use a range of model systems with a major focus on KO and TG mouse models. The techniques that we use range from single molecule mechanics, (immuno) electron microscopy, exon microarray analysis, in vitro motility assays, low angle X-ray diffraction, cell physiology (including calcium imaging), muscle mechanics, and isolated heart physiology.

Associate Director, Omics, Research Scientist, Arizona Research Labs, Research Scientist, Ecology and Evolutionary Biology, Research Scientist, Neurology, Research Scientist, BIO5 Institute

Michael Hammer has headed a productive research lab in human evolutionary genetics. His lab were early adopters of next generation sequencing (NGS) technology successfully employed NGS methods to identify molecular lesions causing neurodevelopmental disorders in undiagnosed children. His lab is also currently pursuing studies to identify modifier genes that alter the expression of major genes and how they contribute to phenotypic heterogeneity in Mendelian disorders.

Professor, Cellular and Molecular Medicine, Co-Chair, ABBS Program, Professor, Biomedical Engineering, Professor, Physiological Sciences - GIDP, Professor, Physiology, Member of the Graduate Faculty, Professor, BIO5 Institute

The long-term goal of research in my lab is to understand the molecular mechanisms of muscle contraction. I am especially interested in how contractile proteins of muscle sarcomeres regulate the force and speed of contraction in the heart. The question is important from both basic science and clinical perspectives because mutations in sarcomere proteins of muscle are a leading cause of hypertrophic cardiomyopathy (HCM), the most common cause of sudden cardiac death in the young and a prevalent cause of heart failure in adults. Myosin binding protein-C (MyBP-C) is a muscle regulatory protein that speeds actomyosin cycling kinetics in response to adrenaline (b-adrenergic stimuli) and is one of the two most commonly affected proteins linked to HCM. Currently, the major research focus in my lab is understanding the mechanisms by which cMyBP-C regulates contractile speed and mechanisms by which mutations in cMyBP-C cause disease.

Assistant Professor, Biomedical / Materials Science Engineer, Assistant Professor, Biomedical Engineering, Member of the Graduate Faculty, Assistant Professor, BIO5 Institute

Minkyu Kim's research interests are in the areas of biopolymers and biomaterials for advanced national defense and healthcare. He is currently working to develop functional biopolymer materials for the treatment of antimicrobial-resistance diseases and atherosclerosis.

Associate Professor, Veterinary Medicine, Assistant Professor, Medicine - (Research Scholar Track), Associate Professor, Pharmacology and Toxicology, Associate Professor, Public Health, Associate Professor, Genetics - GIDP, Adjunct Associate Professor, Nursing, Associate Professor, BIO5 Institute

Walter Klimecki's research program involves the balance between the particular DNA sequence “versions” of genes that we inherit from our ancestors, and the particular environmental exposures that we experience throughout our lives. The Klimecki lab studies diseases resulting from human exposure to arsenic, contributing to a better understanding of the inherited genetic differences between people that result in altered chemical processing of arsenic after it enters the body.

Coordinator, Bac/Est Resource Center
We are a plant genomics lab who specialize in whole genome sequencing and assembly; with analyses of structural variation, gene modeling and transcriptomes. Our work on major projects of rice, corn, barley, etc, allows us to share our technical expertise with other researchers.
Professor, Nutritional Sciences, Professor, Cancer Biology - GIDP, Professor, Physiological Sciences - GIDP, Assistant Dean, Graduate Education, Professor, BIO5 Institute

Kirsten Limesand's research program has its foundation in radiation-induced salivary gland dysfunction; mechanisms of damage, clinical prevention measures, and restoration therapies. They utilize a number of techniques including: genetically engineered mouse models, real-time RT/PCR, immunoblotting, immunohistochemistry, primary cultures, siRNA transfections, and procedures to quantitate salivary gland physiology and integrate this information in order to understand the complete system.

Assistant Professor, Chemistry and Biochemistry-Sci, Assistant Professor, Chemistry and Biochemistry - Med, Assistant Professor, BIO5 Institute

The Marty Lab uses mass spectrometry to study interactions of membrane proteins, peptides, and lipids within nanoscale membrane mimetics.

Professor, Chemistry and Biochemistry-Sci, Professor, Molecular and Cellular Biology, Professor, Applied Mathematics - GIDP, Professor, Cancer Biology - GIDP, Professor, Genetics - GIDP, Professor, BIO5 Institute

We investigate how proteins work in healthy organisms and how they fail in disease. We determine the atomic structures of proteins and the underlying biochemistry that gives rise to protein function. We also develop new proteins as drug targets for treating cancer and cardiovascular disease.

Assistant Professor, Immunobiology, Assistant Professor, Cancer Biology - GIDP, Member of the Graduate Faculty, Research Fellow, BIO5 Institute

All viruses hijack host cell machinery to facilitate their replication. My lab investigates how the production of infectious viral progeny relies on host metabolism. Our overall goal is to guide the development of novel antiviral therapies using information regarding how viruses hijack host metabolism.

Assistant Professor, Cellular and Molecular Medicine, Assistant Professor, Clinical Translational Sciences, Assistant Professor, Genetics - GIDP, Research Fellow, BIO5 Institute

My laboratory aims to identify the genetic and environmental reasons that certain individuals are predisposed to develop complex diseases like heart disease. We use new technologies, experimental, and computational approaches to identify molecular patterns indicative of disease predisposition.

Associate Professor, Biomedical Engineering, Associate Professor, Materials Science and Engineering, Associate Professor, Neurosurgery, Member of the Graduate Faculty, Associate Professor, BIO5 Institute
Associate Research Professor, Pharmacology , Assistant Professor, Chemistry and Biochemistry - Med, Assistant Professor, Chemistry and Biochemistry-Sci, Assistant Professor, Neuroscience - GIDP, Associate Professor, Cancer Biology - GIDP, Associate Professor, Neuroscience - GIDP, Assistant Professor, BIO5 Institute
Associate Professor, Pharmacology and Toxicology, Associate Professor, Cancer Biology - GIDP, Associate Professor, Genetics - GIDP, Associate Professor, BIO5 Institute
Research Associate Professor, BIO5 Institute
Research Professor, Director, Ligand Discovery Laboratory, Research Associate Professor, Pharmacology
Professor, Pharmacology and Toxicology, Professor, Chemistry and Biochemistry, Co-Director, Arizona Center for Drug Discovery, Member of the Graduate Faculty, Endowed Chair, R Ken and Donna Coit - Drug Discovery, Professor, BIO5 Institute
Director, Plant Genomics Institute, Bud Antle Endowed Chair For Excellence, Agriculture-Life Sciences, Professor, Plant Science, Professor, Ecology and Evolutionary Biology, Regents Professor, Professor, BIO5 Institute

Harnessing 15MY of natural variation in the genus Oryza (rice) to help solve the 10-billion people question: i.e. how do we feed our world without destroying our world.

Associate Director, Microbiome, Department Head, Ecology and Evolutionary Biology, Professor, Ecology and Evolutionary Biology, Professor, Genetics - GIDP, Professor, BIO5 Institute
Professor, Professor, Cancer Biology - GIDP, Endowed Chair, Musil Family - Drug Discovery, Professor, BIO5 Institute