Molecular biology
Associate Dean, Research-Agriculture and Life Sciences, Associate Vice President for Research, Agriculture - Life and Veterinary Sciences / Cooperative Extension, Professor, BIO5 Institute, Professor, Cellular and Molecular Medicine, Professor, Molecular and Cellular Biology
Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Chemistry and Biochemistry-Sci
Assistant Professor, BIO5 Institute, Assistant Professor, Molecular and Cellular Biology
Research Professor, Research Professor, BIO5 Institute
Peptides and proteins play a vital role in almost every cellular process in living organisms. Our research discovers and determines structural information on peptides and proteins to design drugs to more effectively treat human disease.
Associate Professor, BIO5 Institute, Associate Professor, Chemistry and Biochemistry-Sci
Professor, BIO5 Institute, Professor, Chemistry and Biochemistry-Sci
The broad objective of our research program in Bioorganic Chemistry and Chemical Biology is to construct protein therapeutics, protein mimetics, biomaterials, and biosensors. Our research at the University of Arizona is highly multidisciplinary and utilizes techniques in organic synthesis, biochemistry, molecular biology, and a host of physical characterization methods. Our research motto is simple: Unraveling mysteries and Enabling discoveries.
Professor, BIO5 Institute, Professor, Biomedical Engineering, Professor, Cellular and Molecular Medicine, Professor, Molecular and Cellular Biology, Professor, Physiological Sciences - GIDP, Professor, Physiology
Our research is focused on elucidating the structure and function of titin and nebulin, two large filamentous proteins found in muscle. We use a range of model systems with a major focus on KO and TG mouse models. The techniques that we use range from single molecule mechanics, (immuno) electron microscopy, exon microarray analysis, in vitro motility assays, low angle X-ray diffraction, cell physiology (including calcium imaging), muscle mechanics, and isolated heart physiology.
Associate Director, Omics, Research Scientist, Arizona Research Labs, Research Scientist, BIO5 Institute, Research Scientist, Ecology and Evolutionary Biology, Research Scientist, Neurology

Michael Hammer has headed a productive research lab in human evolutionary genetics. His lab were early adopters of next generation sequencing (NGS) technology successfully employed NGS methods to identify molecular lesions causing neurodevelopmental disorders in undiagnosed children. His lab is also currently pursuing studies to identify modifier genes that alter the expression of major genes and how they contribute to phenotypic heterogeneity in Mendelian disorders.

Associate Professor, BIO5 Institute, Associate Professor, Physiological Sciences - GIDP, Co-Chair, ABBS Program, Professor, Cellular and Molecular Medicine
The long-term goal of research in my lab is to understand the molecular mechanisms of muscle contraction. I am especially interested in how contractile proteins of muscle sarcomeres regulate the force and speed of contraction in the heart. The question is important from both basic science and clinical perspectives because mutations in sarcomere proteins of muscle are a leading cause of hypertrophic cardiomyopathy (HCM), the most common cause of sudden cardiac death in the young and a prevalent cause of heart failure in adults. Myosin binding protein-C (MyBP-C) is a muscle regulatory protein that speeds actomyosin cycling kinetics in response to adrenaline (b-adrenergic stimuli) and is one of the two most commonly affected proteins linked to HCM. Currently, the major research focus in my lab is understanding the mechanisms by which cMyBP-C regulates contractile speed and mechanisms by which mutations in cMyBP-C cause disease.
Assistant Professor, BIO5 Institute, Assistant Professor, Chemistry and Biochemistry
Andrew Hausrath's lab studies the structures of proteins and complexes using X-ray crystallography, microscopy, and biophysical techniques. Proteins of certain classes are heavily represented as components of complexes. Knowledge of the structures and properties of the proteins which function within higher-order complexes then stimulates development of improved models and theory about how such complexes carry out their functions in the cell. Systems of current interest include the ATP synthase, the signaling hormone adiponectin, and the higher-order organization of chromatin in the nucleus.
Regents Professor Emeritus, Professor Emeritus
Our research is centered on the prevention and treatment of our major degenerative diseases. We concentrate on peptide hormones and neurotransmitters and their receptors that are involved in these major diseases. Specific potential applications include pigmentary disorders, melanoma cancer, feeding disorders, pain, sexual function and motivation, and neurodegenerative diseases such as Alzheimer's, Parkinson's, etc.
Professor, Anesthesiology, Professor, BIO5 Institute, Professor, Neuroscience - GIDP, Professor, Pharmacology
The focus of my laboratory’s’ research is to understand how ion channels, specifically, voltage-gated calcium and sodium channels, are regulated by novel protein interactions. Recent studies in my laboratory have focused on targeting protein-protein interactions with biologics (peptide aptamers) and small molecules; testing the activity of these novel chemical entities in biochemical and immunofluorescent-based assays of trafficking; examining their protein interaction signatures; testing them with whole cell voltage-clamp electrophysiology and voltage- and calcium sensitive fluorescence-based imaging. Regulating these protein networks to modulate the activity of ion channels in neurodegenerative diseases (Chronic Pain, Migraine, and Neurofibromatosis) is a key focus of the laboratory.
Assistant Professor, BIO5 Institute, Assistant Professor, Biomedical / Materials Science Engineer, Assistant Professor, Biomedical Engineering
Minkyu Kim's research interests are in the areas of biopolymers and biomaterials for advanced national defense and healthcare. He is currently working to develop functional biopolymer materials for the treatment of antimicrobial-resistance diseases and atherosclerosis.
Adjunct Associate Professor, Nursing, Assistant Professor, Medicine - (Research Scholar Track), Associate Professor, BIO5 Institute, Associate Professor, Genetics - GIDP, Associate Professor, Pharmacology and Toxicology, Associate Professor, Public Health, Interim Associate Dean, Academic Programs and Faculty Affairs
Walter Klimecki's research program involves the balance between the particular DNA sequence “versions” of genes that we inherit from our ancestors, and the particular environmental exposures that we experience throughout our lives. The Klimecki lab studies diseases resulting from human exposure to arsenic, contributing to a better understanding of the inherited genetic differences between people that result in altered chemical processing of arsenic after it enters the body.
Coordinator, Bac/Est Resource Center
We are a plant genomics lab who specialize in whole genome sequencing and assembly; with analyses of structural variation, gene modeling and transcriptomes. Our work on major projects of rice, corn, barley, etc, allows us to share our technical expertise with other researchers.
Assistant Dean, Graduate Education, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Nutritional Sciences, Professor, Physiological Sciences - GIDP
Kirsten Limesand's research program has its foundation in radiation-induced salivary gland dysfunction; mechanisms of damage, clinical prevention measures, and restoration therapies. They utilize a number of techniques including: genetically engineered mouse models, real-time RT/PCR, immunoblotting, immunohistochemistry, primary cultures, siRNA transfections, and procedures to quantitate salivary gland physiology and integrate this information in order to understand the complete system.
Assistant Professor, BIO5 Institute, Assistant Professor, Chemistry and Biochemistry-Sci
Professor, Applied Mathematics - GIDP, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP, Professor, Genetics - GIDP, Professor, Molecular and Cellular Biology, Professor, Chemistry and Biochemistry-Sci
We investigate how proteins work in healthy organisms and how they fail in disease. We determine the atomic structures of proteins and the underlying biochemistry that gives rise to protein function. We also develop new proteins as drug targets for treating cancer and cardiovascular disease.
Assistant Professor, Immunobiology, Research Fellow, BIO5 Institute
All viruses hijack host cell machinery to facilitate their replication. My lab investigates how the production of infectious viral progeny relies on host metabolism. Our overall goal is to guide the development of novel antiviral therapies using information regarding how viruses hijack host metabolism.
Assistant Professor, Cellular and Molecular Medicine, Research Fellow, BIO5 Institute
My laboratory aims to identify the genetic and environmental reasons that certain individuals are predisposed to develop complex diseases like heart disease. We use new technologies, experimental, and computational approaches to identify molecular patterns indicative of disease predisposition.
Associate Professor, BIO5 Institute, Associate Professor, Biomedical Engineering, Associate Professor, Materials Science and Engineering
Assistant Professor, BIO5 Institute, Assistant Professor, Chemistry and Biochemistry - Med, Assistant Professor, Chemistry and Biochemistry-Sci, Assistant Professor, Neuroscience - GIDP
Associate Professor, BIO5 Institute, Associate Professor, Cancer Biology - GIDP, Associate Professor, Genetics - GIDP, Associate Professor, Pharmacology and Toxicology
Research Associate Professor, BIO5 Institute
Director, Ligand Discovery Laboratory, Research Associate Professor, Pharmacology, Research Professor
Director, Drug Discovery Program, Professor, Pharmacology and Toxicology
Bud Antle Endowed Chair For Excellence, Agriculture-Life Sciences, Director, Plant Genomics Institute, Professor, BIO5 Institute, Professor, Ecology and Evolutionary Biology, Professor, Plant Science, Regents Professor
Harnessing 15MY of natural variation in the genus Oryza (rice) to help solve the 10-billion people question: i.e. how do we feed our world without destroying our world.
Associate Director, Microbiome, Department Head, Ecology and Evolutionary Biology, Professor, BIO5 Institute, Professor, Ecology and Evolutionary Biology, Professor, Genetics - GIDP
Professor, Professor, BIO5 Institute, Professor, Cancer Biology - GIDP