Luo, Y., Gelsinger, P. J., Barton, J. K., Barbastathis, G., & Kostuk, R. K. (2008). Multiplexing volume holographic gratings for a spectral-spatial imaging system. PRACTICAL HOLOGRAPHY XXII: MATERIALS AND APPLICATIONS, 6912.
Barton, J., Davidson, B. R., & Barton, J. K. (0). Application of optical coherence tomography to automated contact lens metrology. Journal of biomedical optics, 15(1).
Optical coherence tomography (OCT) is a nondestructive imaging modality with the potential to make quantitative spatial measurements. OCT's noncontact nature, sensitivity to small refractive index mismatches, and micron-scale resolution make it attractive for contact lens metrology, specifically, measuring prism. Prism is defined as the maximum difference in thickness of the contact lens, measured over a full 360 deg of rotation, at a fixed distance from the contact lens edge. We develop and test a novel algorithm that automatically analyzes OCT images and calculates prism. Images are obtained using a Thorlabs OCT930SR OCT system. The OCT probe is fastened to an automated rotation stage that rotates 360 deg in small increments (typically 10 deg) to acquire OCT images of the edge of the contact lens around the entire circumference. The images are 1.6 mm in optical depth (512 pixels) and 2 mm wide (1000 pixels). Several sets of images are successfully analyzed. The prism measured for a toric lens is 42 microm, which is in line with design parameters. Thickness measurements are repeatable with a standard deviation of 0.5 microm and maximum range of 1.8 microm over ten image sets. This work demonstrates the possibility of using OCT to perform nondestructive contact lens metrology.
Korde, V., Zhao, D., Raghunand, N., Black, J. F., Gillies, R., & Barton, J. K. (2007). Using methemoglobin as a magnetic resonance imaging contrast agent. LASERS IN SURGERY AND MEDICINE, 3-3.
Winkler, A. M., Rice, P., Weichsel, J., Backer, M. V., Backer, J. M., & Barton, J. K. (2009). In vivo imaging using a VEGF-based near-infrared fluorescent probe for early cancer diagnosis in the AOM-treated mouse model. REPORTERS, MARKERS, DYES, NANOPARTICLES, AND MOLECULAR PROBES FOR BIOMEDICAL APPLICATIONS, 7190.
Barton, J., Winkler, A. M., Rice, P. F., Drezek, R. A., & Barton, J. K. (0). Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon. Journal of biomedical optics, 15(4).
Optical coherence tomography (OCT) can provide new insight into disease progression and therapy by enabling nondestructive, serial imaging of in vivo cancer models. In previous studies, we have shown the utility of endoscopic OCT for identifying adenomas in the azoxymethane-treated mouse model of colorectal cancer and tracking disease progression over time. Because of improved imaging speed made possible through Fourier domain imaging, three-dimensional imaging of the entire mouse colon is possible. Increased amounts of data can facilitate more accurate classification of tissue but require more time on the part of the researcher to sift through and identify relevant data. We present quantitative software for automatically identifying potentially diseased areas that can be used to create a two-dimensional "disease map" from a three-dimensional Fourier domain OCT data set. In addition to sensing inherent changes in tissue that occur during disease development, the algorithm is sensitive to exogeneous highly scattering gold nanoshells that can be targeted to disease biomarkers. The results of the algorithm were compared to histological diagnosis. The algorithm was then used to assess the ability of gold nanoshells targeted to epidermal growth factor receptor in vivo to enable functional OCT imaging.
