Jennifer Kehlet Barton
Director, BIO5 Institute
Professor, Agricultural-Biosystems Engineering
Professor, BIO5 Institute
Professor, Biomedical Engineering
Professor, Electrical and Computer Engineering
Professor, Medical Imaging
Professor, Optical Sciences
Primary Department
Department Affiliations
(520) 626-0314
Work Summary
I develop new optical imaging devices that can detect cancer at the earliest stage. Optics has the resolution and sensitivity to find these small, curable lesions, and we design the endoscope that provide access to organs inside the body. .
Research Interest
Jennifer Barton, Ph.D. is known for her development of miniature endoscopes that combine multiple optical imaging techniques,particularly optical coherence tomography and fluorescence spectroscopy. She evaluates the suitability of these endoscopic techniques for detecting early cancer development in patients and pre-clinical models. She has a particular interest in the early detection of ovarian cancer, the most deadly gynecological malignancy. Additionally, her research into light-tissue interaction and dynamic optical properties of blood laid the groundwork for a novel therapeutic laser to treat disorders of the skin’s blood vessels. She has published over 100 peer-reviewed journal papers in these research areas. She is currently Professor of Biomedical Engineering, Electrical and Computer Engineering, Optical Sciences, Agriculture-Biosystems Engineering, and Medical Imaging at the University of Arizona. She has served as department head of Biomedical Engineering, Associate Vice President for Research, and is currently Director of the BIO5 Institute, a collaborative research institute dedicated to solving complex biology-based problems affecting humanity. She is a fellow of SPIE – the International Optics Society, and a fellow of the American Institute for Medical and Biological Engineering. Keywords: bioimaging, biomedical optics, biomedical engineering, bioengineering, cancer, endoscopes


Barton, J., Kariya, R., Mathine, D. L., & Barton, J. K. (2004). Analog CMOS circuit design and characterization for optical coherence tomography signal processing. IEEE transactions on bio-medical engineering, 51(12).

We have developed a custom analog CMOS circuit to perform the signal processing for an optical coherence tomography imaging system. The circuit is realized in a 1.5 microm low-noise analog CMOS technology. The circuitry extracts the Doppler frequency from the signal and electrically mixes this with the original signal to provide a filtered A-scan. The circuitry was used to produce a two-dimensional image of an onion.

Zhang, Y., Davidson, B. R., Stamer, W. D., Barton, J. K., Marmorstein, L. Y., & Marmorstein, A. D. (2009). Enhanced inflow and outflow rates despite lower IOP in bestrophin-2-deficient mice. Investigative ophthalmology & visual science, 50(2), 765-70.

Bestrophin-2 (Best2), a putative Cl(-) channel is expressed in the nonpigmented epithelium (NPE). Disruption of Best2 in mice results in a diminished intraocular pressure (IOP). Aqueous humor dynamics were compared in Best2(+/+) and Best2(-/-) mice, to better understand the contribution of Best2 to IOP.

Arauz, L. J., Luo, Y., Castillo, J. E., Barton, J., & Kostuk, R. K. (2008). Fiber array fabrication technique for 15-mu m-diameter single-mode fibers. OPTICAL ENGINEERING, 47(7).
Korde, V. R., Bartels, H., Barton, J., & Ranger-Moore, J. (2009). Automatic segmentation of cell nuclei in bladder and skin tissue for karyometric analysis. Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology, 31(2), 83-9.

To automatically segment cell nuclei in histology images of bladder and skin tissue for karyometric analysis.

Bonnema, G. T., Cardinal, K. O., Williams, S. K., & Barton, J. K. (2008). Imaging stented tissue engineered blood vessel mimics. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE II, 6858.