Tewary, P., Gunatilaka, L., & Sayers, T. (2017). Using natural products to promote caspase-8-dependent cancer cell death. Cancer Immunology Immunotherapy, 66, 223-231. doi:10.1007/s00262-016-1855-0
Wijeratne, E. M., Lankananda, B. D., Tezuka, Y., Nagaoka, T., & Gunatilaka, A. A. (2001). Dimeric aporphine alkaloids of Phoenicanthus obliqua from Sri Lanka. Journal of Natural Products, 64(11), 1465-1467.
PMID: 11720536;Abstract:
A new dimeric aporphine alkaloid, phoenicanthusine (1), and six known alkaloids were isolated from the stem bark of Phoenicanthus obliqua. The structure of 1 was elucidated by 1D (1H, 13C) and 2D (1H-1H COSY, HMQC, HMBC, and NOESY) NMR and HRMS studies. Phoenicanthusine represents the first example of a N-6-C-4′ and C-7-C-5′ linked dimeric aporphine alkaloid.
Da, V., Izumisawa, C. M., Claudia, M., M., L., G., D., & Gunatilaka, A. L. (1997). Iridoids from Tocoyena formosa. Phytochemistry, 46(2), 305-308.
Abstract:
The leaves of Tocoyena formosa afforded two antifungal iridoids α- and β-gardiol, and the new iridoids, mollugoside methyl ester and formosinoside. Formosinoside was characterized as its hexaacetyl derivative.
Paranagama, P. A., M., E., & A., A. (2007). Uncovering biosynthetic potential of plant-associated fungi: Effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii. Journal of Natural Products, 70(12), 1939-1945.
PMID: 18052326;Abstract:
In an attempt to uncover the biosynthetic potential of plant-associated fungi, the effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii was investigated. These studies indicated that the production of the major metabolites by P. quadriseptata differ when the water used to make the media was changed from tap water to distilled water. It resulted in the isolation of six new secondary metabolites, cytosporones F-I (1-4), quadriseptin A (5), and 5′-hydroxymonocillin III (6) together with monocillin III (7), a metabolite new to P. quadriseptata, in addition to monocillin I (8), a previously known metabolite from this organism. Aposphaerin B (9) encountered was suspected to be an artifact originating from cytosporone F (1). Incorporation of heavy metal ions to P. quadriseptata culture medium induced production of monocillin I (8) by this fungus. Cultivation of C. chiversii in liquid medium resulted in the isolation of chaetochromin A (12) as the major metabolite instead of radicicol (10), the major constituent of this organism when grown in a solid medium. Compounds 1-7 and 12 were evaluated for their potential to inhibit Hsp90 and antiproliferative activity toward the cancer cell lines NCI-H460, MCF-7, and SF-268. Only compounds 6, 7, and 8 exhibited significant activity in both assays. © 2007 American Chemical Society and American Society of Pharmacognosy.
Wijeratne, K., Oliviera, M., Mafazoli, J., Xu, Y., Minguzzi, S., Batista, P., Pessoa, O., Whitesell, L., & Gunatilaka, L. (2017). Withaferin A and Withanolide D Analogues with Dual Heat-Shock-Inducing and Cytotoxic Activities: Semisynthesis and Biological Evaluation. Journal of Natural Products.