Yan, J., Mitra, A., Hu, J., Cutrera, J. J., Xia, X., Doetschman, T., Gagea, M., Mishra, L., & Li, S. (2016). Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells. Journal of Hepatology.
Sepsis is an acute systemic inflammatory response to infection associated with high patient mortality (28-40%). We hypothesized that interleukin (IL)-30, a novel cytokine protecting mice against liver injury resulting from inflammation, would generate a protective effect against systemic inflammation and sepsis-induced death.
Doetschman, T., Sholl, A., Chen, H., Gard, C., Hildeman, D., & Bommireddy, R. (2011). Divergent effects of calcineurin Abeta on regulatory and conventional T-cell homeostasis. Clinical Immunology, 138(3), 321-330.
Thomas, R., Belsito, D., Huang, C., Chen, L. L., Ormsby, I., Simmons, W., Cowin, P., Shaw, J., Doetschman, T., & Thorbecke, G. (2001). Appearance of Langerhans cells in the epidermis of Tgfb1(-/-) SCID mice: paracrine and autocrine effects of transforming growth factor-beta 1 and -beta 2(1).. J Invest Dermatol, 117, 1574-1580.
House, S., Melhorn, S., Newman, G., Doetschman, T., & Schultz, J. J. (2007). The protein kinase C pathway mediates cardioprotection induced by cardiac-specific overexpression of fibroblast growth factor-2. American Journal of Physiology. Heart and Circulatory Physiology, 293(1), H354-H365.
Lee, H., Chen, S., Doetschman, T., Deng, C., D'Agati, V., & Kim, M. (2008). Sevoflurane protects against renal ischemia and reperfusion injury in mice via the transforming growth factor-beta1 pathway. American Journal of Physiology. Renal Physiology, 295(1), F128-F136.