Nutritional Sciences

Building Bridges, Building Communities: Dr. Melanie Hingle

Dr. Melanie Hingle
UArizona CALES

The University of Arizona Office of Research, Innovation & Impact has named Dr. Melanie Hingle, professor in the School of Nutritional Sciences and Wellness (NSW), to its 2023 class of Women of Impact - a cohort of 30 female-identifying faculty and staff whose leadership and unique skills advance the university’s mission, vision, and purpose as a world-class institution.

AHA News: The 'Hispanic Paradox': Does A Decades-Old Finding Still Hold Up?

Hispanic Man
U.S. News

Many Hispanic people in the United States face socioeconomic disadvantages and lower access to affordable health care. Despite these and other challenges to their health, they generally tend to live longer than other racial or ethnic communities – a health phenomenon that's been studied for decades.

A Look at The Cost of Climate Change on Human Health

UArizona Health Sciences

The evidence is clear – climate change is having a negative effect on our physical and mental health. The scale of the impact is vast, with millions of people around the world already facing the consequences of climate change daily.

New UArizona Initiative To Help Communities Harness The Power of Food As Medicine

2 people cooking in a kitchen. One with a lab coat that has the Arizona "A."
UArizona News
A new initiative at UArizona will work to reduce the burden of diet-sensitive disease in vulnerable Arizona communities using culinary medicine — an emerging field that blends the art of cooking with the science of medicine and nutrition to use food to prevent and help manage chronic diseases like diabetes.

Aging Experts To Address UArizona Living Healthy With Arthritis Virtual Conference

Elderly lady washing hands.
UArizona Health Sciences
Dr. Janko Nikolich-Žugich and other experts in the health and wellness of the aging population, will deliver a combined keynote address at the UArizona Arthritis Center’s annual “Living Healthy With Arthritis” conference.

Crushing cancer with innovative, interdisciplinary approaches

Cancer cells under a microscope - National Cancer Institute
Dr. Brittany Uhlorn, BIO5 Institute

You likely know someone who has battled cancer, whether it be a loved one, a colleague, or yourself. Cancer is the second leading cause of death in the U.S., so finding better prevention, diagnostic, and treatment strategies is essential to defeating this public health concern to help us lead healthier, longer lives. 

As residents of Arizona, we are no strangers to ample sunshine. While being outside is beneficial to our well-being, too much exposure to sun is  a major contributing factor to skin cancer, the most common type of cancer in the U.S. At least 5 million people in our country are treated for skin cancer annually, resulting in more than $8 billion in medical expenses. 

Curiel and Kang
Dr. Clara Curiel-Lewandrowski and Dr. Dongkyun Kang

Co-director of the Skin Cancer Institute Dr. Clara Curiel-Lewandrowski teamed up with Dr. Dongkyun Kang, assistant professor of optical sciences and biomedical engineering, to develop a novel device that uses reflectance confocal microscopy (RCM) to facilitate noninvasive imaging of the skin. This will allow doctors to quickly and safely diagnose many skin cancers, as well as monitor treatment responses without a biopsy.

Gastrointestinal (GI) cancers collectively represent one of the greatest public health challenges, accounting for more than one-quarter of all global cancer cases and more than 35% of all cancer-related deaths. Many of these cancers, including pancreatic and biliary, have been historically hard to treat. 

Dr. Rachna Shroff, associate dean of clinical and translational research and chief of GI medical oncology at the UArizona Cancer Center, uses genomic profiling of tumors to tackle stubborn gastrointestinal cancers. She also supports other researchers and clinicians in translating their findings from bench to bedside through her role as director of the Arizona Clinical Trials Network. Shroff’s passion for studying and treating patients with these cancers stems from the dire global need and her desire to improve quality of life.

“GI cancers are a global problem, and at the end of the day, unfortunately, the outcomes are quite grim for patients with a lot of GI cancers,” she said. “As somebody who knew that she wanted to do clinical trials and drug development, this seemed like a space where there was a huge need for more people working, thinking, and trying to be creative about novel clinical trial designs to help improve the outcomes for these patients.”

Ovarian cancer is the deadliest gynecological cancer in the U.S. Because the ovaries are located deep in the body, this type of cancer generally presents without early symptoms and currently has no effective screening techniques. 

Dr. Jennifer Barton and the falloposcope

Dr. Jennifer Barton, director of the BIO5 Institute and Thomas R. Brown Distinguished Chair in biomedical engineering, has invented a novel falloposcope imaging device with three high-resolution optical imaging techniques that will enable earlier detection of ovarian cancer.  In a pilot trial that began in fall 2021, Barton is working with Dr. John Heusinkveld, an assistant professor of obstetrics and gynecology at the College of Medicine – Tucson and a board-certified specialist in female pelvic medicine and reconstructive surgery in Banner – University Medical Center Tucson's Department of Obstetrics and Gynecology. to test the device in humans. 

Breast cancer is the most common cancer in women and the second leading cause of cancer-related death in the U.S. The American Cancer Society estimated that more than 280,000 new cases of invasive breast cancer would be diagnosed in 2021. Dr. Donato Romagnolo, professor in the School of Nutritional Sciences and Wellness; Dr. Ornella Selmin, research associate professor of nutritional sciences; Dr. Cynthia Thomson, Director of the Canyon Ranch Center for Prevention and Health Promotion; and Dr. Janet Funk, professor in the College of Medicine - Tucson; are studying how different foods and supplements may prevent breast cancer or lessen its aggressiveness.

Dr. Cynthia Thomson

Oral, head and neck cancers account for more than 330,000 deaths worldwide annually and 4% of all cancers in the U.S. Human papillomavirus (HPV), though typically known for causing genital warts and cervical cancer, is also emerging as leading cause of head and neck cancers, especially in the U.S. Scientists still don’t know exactly how the virus is able to infect and persist in our cells for years without being detected by the immune system. 

Dr. Samuel Campos, associate professor of immunobiology, molecular and cellular biology, and cancer biology, aims to understand the complex interactions between HPV and our cells – particularly how the virus enters and evades detection.

“Viruses like HPV are the original, and best, cell biologists,” Campos said. “Studying their basic biology will yield great and unexpected insights into humans and how our cells work at fundamental levels.”

Campos collaborates with Dr. Koenraad Van Doorslaer, assistant professor of virology and genetics, who studies why evolutionarily related viruses differ in their carcinogenic abilities. Their work will ultimately pave the way for better prevention, detection and treatment strategies for HPV infection and HPV-related oral, head, and neck cancers.

Tackling a grand scientific and medical challenge like cancer requires collaboration between physicians, scientists, engineers, computational researchers, translational innovation partners like Tech Launch Arizona and more. This approach is supported by the interdisciplinary environment of the BIO5 Institute, which exists because of continued funding from the Technology and Research Initiative Fund (TRIF) that helped launch BIO5 in 2001. Moreover, additional federal grant funding to continue this work is bolstered by early-stage, foundational and seed grants from BIO5.

About the University of Arizona BIO5 Institute
The BIO5 Institute at the University of Arizona connects and mobilizes top researchers in agriculture, engineering, medicine, pharmacy, data and computational science, and basic science to find creative solutions to humanity’s most pressing health and environmental challenges. Since 2001, this interdisciplinary approach has been an international model of how to conduct collaborative research, and has resulted in disease prevention strategies, innovative diagnostics and devices, promising new therapies, and improved food sustainability.

About the Technology and Research Initiative Fund (TRIF)
The Technology and Research Initiative Fund (TRIF) that helped launch BIO5 in 2001 continues to be a catalyst in enabling effective, cross-disciplinary bioscience research and innovation at the University of Arizona, where initiatives and projects are carefully chosen to align with areas of state and national need. Since 2001, over $50M has been invested in building critical facilities and research services that UArizona is leveraging today to respond to the world’s greatest scientific mysteries. TRIF resources are also instrumental in funding events, programs and grants that promote STEM education, research and literacy.