Corn rootworms are evolving resistance that threatens even the newest biotech defense combining Bt and RNA interference. BIO5 members Bruce Tabashnik and Yves Carrière found the pests adapt quickly, urging integrated pest management to protect crops and farmers.

BIO5 member John Elfar led a UArizona study showing the multiple sclerosis drug 4-aminopyridine accelerates bone fracture healing in mice. The drug boosted BMP2 activity, bone mass, and osteoblast growth, suggesting potential for faster, stronger recovery in future clinical applications.

BIO5 member Maya Kaelberer co-led a study uncovering a “gut sense” where colon neuropod cells directly signal the brain when bacteria release flagellin during eating.