Dominic V Mcgrath
Hydroxymethyl substituted aromatic heterocycles, including pyridines, furans, and thiophenes, are oxidized to the corresponding aldehydes in excellent yields by 4-acetylamino-2,2,6,6-tetramethylpiperidine-1- oxoammonium perchlorate (1) with minimal workup.
[IrH2(CF3CO2)(Pcy3) 2] (cy = cyclohexyl) catalyses the photochemical dehydrogenation of cyclo-octane both in the presence and absence of a hydrogen-acceptor.
The concept is simple, within the pump a pH responsive polymer actuator swells in volume under electrically controlled stimulus. As the actuator swells it presses against a drug reservoir, as the reservoir collapses the drug is metered out to the patient. From concept to finished product, engineering this smart system entailed integration across multiple fields of science and engineering. Materials science, nanotechnology, polymer chemistry, organic chemistry, electrochemistry, molecular engineering, electrical engineering, and mechanical engineering all played a part in solutions to multiple technical hurdles. Some of these hurdles where overcome by tried and true materials and component engineering, others where resolved by some very creative out of the box thinking and tinkering. This paper, hopefully, will serve to encourage others to venture into unfamiliar territory as we did, in order to overcome technical obstacles and successfully develop a low cost smart medical device that can truly change a patient's life. © 2012 SPIE.