Dominic V Mcgrath
Publications
Abstract:
We present the preparation of a series of chiral dendrons, in which chiral subunits are placed in individual generational shells at increasing distances from the focal point, by a combination of convergent and divergent dendrimer synthesis methods. Analysis of chiroptical data suggests that these dendrons do not possess conformational order in solution.
Abstract:
Conditions for the self-metathesis assembly of dendrons with alkenyl focal points into dendrimers are developed. Assembly of more complex central cores is the subject of current efforts. Olefin metathesis has become a powerful method in organic synthesis. Several ruthenium-based alkylidiene complexes have led to considerable success in the ring-opening metathesis and ring-closing metathesis reactions in application to the total synthesis of natural products. A preliminary study on the use of metathesis to assemble benzyl aryl ether dendrimers is reported. Self-metathesis yielding dendrimers is observed and the effects of solvent, temperature and reaction conditions on final product yield is optimized.
Abstract:
The ring-opening metathesis polymerization (ROMP) of strained cyclic olefins is an important application of the olefin metathesis reaction. We have shown that the aqueous ROMP of exo-N-Methyl-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboximide yields a high molecular weight, thermally stable polymer with a low polydispersity in high yields under mild conditions. The mechanical properties and possible applications of these polymers are currently being investigated.