Lussier, Y. A. (2015). eQTL networks unveil enriched mRNA master integrators downstream of complex disease-associated SNPs. Journal of Biomedical Informatics.
Yan, X., Chu, J., Gomez, J., Koenigs, M., Holm, C., He, X., Perez, M. F., Zhao, H., Mane, S., Martinez, F. D., Ober, C., Nicolae, D. L., Barnes, K. C., London, S. J., Gilliland, F., Weiss, S. T., Raby, B. A., Cohn, L., & Chupp, G. L. (2015). Noninvasive analysis of the sputum transcriptome discriminates clinical phenotypes of asthma. American journal of respiratory and critical care medicine, 191(10), 1116-25.
The airway transcriptome includes genes that contribute to the pathophysiologic heterogeneity seen in individuals with asthma.
Martinez, F. D. (2016). Beyond the Paradigm of Asthma as an Inflammatory Disease. A Summary of the 2015 Aspen Lung Conference. Annals of the American Thoracic Society, 13 Suppl 1, S91-4.
Sheehan, W. J., Mauger, D. T., Paul, I. M., Moy, J. N., Boehmer, S. J., Szefler, S. J., Fitzpatrick, A. M., Jackson, D. J., Bacharier, L. B., Cabana, M. D., Covar, R., Holguin, F., Lemanske, R. F., Martinez, F. D., Pongracic, J. A., Beigelman, A., Baxi, S. N., Benson, M., Blake, K., , Chmiel, J. F., et al. (2016). Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. The New England journal of medicine, 375(7), 619-30.
Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking.
Gerald, J. K., Gerald, L. B., Vasquez, M. M., Morgan, W. J., Boehmer, S. J., Lemanske, R. F., Mauger, D. T., Strunk, R. C., Szefler, S. J., Zeiger, R. S., Bacharier, L. B., Bade, E., Covar, R. A., Guilbert, T. W., Heidarian-Raissy, H., Kelly, H. W., Malka-Rais, J., Sorkness, C. A., Taussig, L. M., , Chinchilli, V. M., et al. (2016). Markers of Differential Response to Inhaled Corticosteroid Treatment Among Children with Mild Persistent Asthma. The journal of allergy and clinical immunology. In practice, 3(4), 540-6.e3.
Inhaled corticosteroids are recommended as first-line therapy for children with mild persistent asthma; however, specific patient characteristics may modify the treatment response.