Fernando Martinez

Fernando Martinez

Professor, Pediatrics
Director, Asthma / Airway Disease Research Center
Endowed Chair, Swift - McNear
Regents Professor
Professor, Genetics - GIDP
Professor, BIO5 Institute
Contact
(520) 626-5954

Research Interest

Dr. Fernando D. Martinez is a Regents’ Professor and Director of the Asthma & Airway Disease Research Center at the University of Arizona in Tucson. Dr. Martinez is a world-renowned expert, and one of the most highly regarded researchers, in the field of childhood asthma. His primary research interests are the natural history, genetics, and treatment of childhood asthma. His groundbreaking research has had an impact on his field in numerous ways, most prominent among them the development of the concept of the early origins of asthma and COPD. This concept is now widely accepted as the potential basis for the design of new strategies for the prevention of these devastating illnesses affecting millions of children and adults worldwide. In addition, Dr. Martinez has made important contributions to our understanding of the role of gene-environment interactions in the development of asthma and allergies. He has also been the principal investigator of one of the Clinical Centers that are part of the NHLBI Asthma Treatment Networks, which have contributed fundamental new evidence on which to base national guidelines for the treatment of the disease. Dr. Martinez currently serves on national scientific boards including the NHLBI National Advisory Council and the National Scientific Council on the Developing Child. He was a member of the National Asthma Education and Prevention Program that was responsible for the development of the Expert Panel Report: Guidelines for the Diagnosis and Management of Asthma in 1997 and its first revision in 2001. He also has been a member of the FDA Pulmonary-Allergy Drugs Advisory Committee and the Board of Extramural Advisors of the National Heart, Lung, and Blood Institute (NHLBI). Dr. Martinez’s research and vision are well detailed in more than 250 original research papers and editorials, many in collaboration with investigators from all over the world. He is frequently invited to give keynote presentations at national and international meetings.

Publications

Lussier, Y. A. (2015). eQTL networks unveil enriched mRNA master integrators downstream of complex disease-associated SNPs. Journal of Biomedical Informatics.
Yan, X., Chu, J., Gomez, J., Koenigs, M., Holm, C., He, X., Perez, M. F., Zhao, H., Mane, S., Martinez, F. D., Ober, C., Nicolae, D. L., Barnes, K. C., London, S. J., Gilliland, F., Weiss, S. T., Raby, B. A., Cohn, L., & Chupp, G. L. (2015). Noninvasive analysis of the sputum transcriptome discriminates clinical phenotypes of asthma. American journal of respiratory and critical care medicine, 191(10), 1116-25.

The airway transcriptome includes genes that contribute to the pathophysiologic heterogeneity seen in individuals with asthma.

Martinez, F. D. (2016). Beyond the Paradigm of Asthma as an Inflammatory Disease. A Summary of the 2015 Aspen Lung Conference. Annals of the American Thoracic Society, 13 Suppl 1, S91-4.
Sheehan, W. J., Mauger, D. T., Paul, I. M., Moy, J. N., Boehmer, S. J., Szefler, S. J., Fitzpatrick, A. M., Jackson, D. J., Bacharier, L. B., Cabana, M. D., Covar, R., Holguin, F., Lemanske, R. F., Martinez, F. D., Pongracic, J. A., Beigelman, A., Baxi, S. N., Benson, M., Blake, K., , Chmiel, J. F., et al. (2016). Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. The New England journal of medicine, 375(7), 619-30.

Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking.

Gerald, J. K., Gerald, L. B., Vasquez, M. M., Morgan, W. J., Boehmer, S. J., Lemanske, R. F., Mauger, D. T., Strunk, R. C., Szefler, S. J., Zeiger, R. S., Bacharier, L. B., Bade, E., Covar, R. A., Guilbert, T. W., Heidarian-Raissy, H., Kelly, H. W., Malka-Rais, J., Sorkness, C. A., Taussig, L. M., , Chinchilli, V. M., et al. (2016). Markers of Differential Response to Inhaled Corticosteroid Treatment Among Children with Mild Persistent Asthma. The journal of allergy and clinical immunology. In practice, 3(4), 540-6.e3.

Inhaled corticosteroids are recommended as first-line therapy for children with mild persistent asthma; however, specific patient characteristics may modify the treatment response.