Cell metabolism is a tightly controlled process that uses numerous feedback and feed-forward mechanisms to provide the necessary requirements to sustain growth. Many of these regulatory mechanisms are mediated through the post-translational modification of enzymes that serve to modulate activity and function. My laboratory studies the link between cell metabolism, protein post-translational modifications, and gene expression. We utilize mass spectrometry to investigate both novel and established metabolic feedback mechanisms and how these go awry in disease. Current work centers on histone modifications derived from cell metabolism and how these modifications are disrupted in diabetes and cancer.