Professor, Biomedical Engineering
Professor, Applied Mathematics - GIDP
Professor, Cognitive Science - GIDP
Professor, Neuroscience - GIDP
Professor, Physiological Sciences - GIDP
Member of the Graduate Faculty
Member of the Graduate Faculty
My work generally aims at bridging Computational and Experimental Neuroscience. How do neurons compute, individually and as a group? The laboratory wirelessly collects neural data from rats performing complex spatial navigation tasks in one of the largest mazes in the country. We are also interested in the role of neuromodulation in cognitive and emotional behaviors.
Fellous did his doctoral work in pattern recognition and Artificial Intelligence at the University of Southern California. He did postdoctoral work in experimental neuroscience (in vitro) at Brandeis University and the Salk Institute for Biological studies. He created the Computational and Experimental Laboratory (in vivo) at Duke University before moving to the University of Arizona where he is a full professor in the departments of Psychology and Biomedical Engineering. His research interests include the neurobiology of complex learning and emotional memory and the mechanisms and roles of neuromodulation in large neural networks in the context of spatial navigation. His laboratory uses a multi-disciplinary approach that includes computational, in vitro and in vivo techniques. The primary focus of the research is to understand how complex memories persist and are transformed in large populations of neurons. How are multiple memories simultaneously processed without interfering with each other? How does learning 'optimize' large scale computations? How do recent memories influence upcoming decision making? Can memories be selectively altered? How do memories change during sleep? Current research foci include complex spatial navigation processing by the hippocampal and prefrontal systems. The secondary focus is to understand how neural computations can be dynamically re-configured to reflect the constraints dictated by changes in behavioral, emotional and cognitive contexts. These contexts are often associated with the release of neuromodulators such as dopamine (e.g. reinforcement learning), acetylcholine (e.g. sleep and memory) or serotonin (e.g. motivation and emotion). How do these substances change the flow of information and regulate learning and memory? Current research foci include spatial memory consolidation during sleep, Post Traumatic Stress Disorder and empathy. The experimental aspects of this research include a combination of in vitro and in vivo techniques in the rat. The lab uses state of the art neurophysiology techniques that include two-way real-time brain-machine interfaces, wireless recordings and "hyperdrives" allowing for the simultaneous recordings of many neurons in the behaving animal. The laboratory also recently started using optogenetic tools to manipulate neural activity in vivo using light, and small robots that co-navigate with the rats. The theoretical aspects of the work involves the use of computational modeling techniques to simulate the activity of single cells and networks of interconnected cells. These computer simulations reproduce and explain experimental data, and generate predictions that can in turn be tested experimentally. We also are interested in Artificial Intelligence techniques for the analysis of large datasets.