Julie Elizabeth Miller
Assistant Professor
Assistant Professor, BIO5 Institute
Assistant Professor, Neurology
Assistant Professor, Neuroscience - GIDP
Assistant Professor, Speech and Hearing Science
Primary Department
Department Affiliations
(520) 626-0100
Work Summary
I am a neuroscientist who studies the impact of aging and neurodegenerative disease on voice and speech. My laboratory seeks a better understanding of the molecules, cells and circuits in the brain that support vocal production.
Research Interest
My laboratory studies neurogenetic mechanisms which underlie normal and abnormal motor speech using the zebra finch songbird. My particular focus is to investigate molecular and cellular pathways altered by speech disorders associated with natural aging and neurological diseases such as Parkinson’s Disease. To carry out these investigations, we use a combination of behavioral, genetic, biochemical and electrophysiological approaches that enable us to link changes at the molecular/cellular levels to alterations in neural circuits for birdsong/human speech. We also have collaborations with researchers working in mouse models to understand shared molecular pathway for vocal function. The end goal is to leverage the advantages offered by each species and an array of biological tools to further advance our understanding of how the brain controls vocalizations. Our laboratory website, including an updated publication list, can be found at: https://julieemiller.lab.arizona.edu/content/publications-abstracts

Publications

Grant, L. M., Richter, F., Miller, J., White, S., Fox, C., Chesselet, M., & Ciucci, M. (2014). Vocalization deficits in mice over-expressing alpha-synuclein, a model of pre-manifest Parkinson's disease.. Behav Neurosci, 128, 110-121.
Hilliard, A. T., Miller, J., Horvath, S., & White, S. (2012). Distinct Neurogenomic States in Basal Ganglia Subregions Relate Differently to Singing Behavior in Songbirds. PloS Comput Biol, 8(11), e1002773.
Miller, J. E. (2015). Reduced vocal variability in a zebra finch model of dopamine depletion: implications for Parkinson disease.. Physiological Reports, 3(11). doi:10.14814/phy2.12599
Hilliard, A., Miller, J., Fraley, E., Horvath, S., & White, S. (2012). Molecular Microcircuitry Underlies Functional Specification in a Basal Ganglia Circuit Dedicated to Vocal Learning. Neuron, 73, 537-552.