Matthew Dennis Grilli
Assistant Professor, BIO5 Institute
Assistant Professor, Cognitive Science - GIDP
Assistant Professor, Evelyn F Mcknight Brain Institute
Assistant Professor, Neurology
Assistant Professor, Psychology
Primary Department
Department Affiliations
(520) 621-7447
Work Summary
My research interests are broadly focused on understanding how and why we store and retrieve memories. The clinical and cognitive neuroscience research conducted in my laboratory combines neuropsychological, cognitive, social psychological, and neuroimaging approaches. An emphasis of my current research is autobiographical memory, which refers to memories of personal experiences. Ongoing projects are investigating how autobiographical memory is affected in several populations, including older adults at risk for Alzheimer’s disease and individuals with acquired brain injury. We also are interested in understanding how changes to autobiographical memory impact other aspects of cognition, and we seek to develop new interventions to improve autobiographical memory and everyday functioning.
Research Interest
My research interests are broadly focused on understanding the reciprocal relations of self and memory. How does the self influence learning and memory retrieval? How does memory contribute to one's sense of self? Uncovering the ways in which the self and memory interact may advance understanding of identity, elucidate the conditions and experiences that modify the self, and inspire clinical interventions that improve quality of life and wellbeing for people who have neurological or mental health conditions. Ongoing projects are investigating how to improve memory through self-referential encoding strategies in individuals with traumatic brain injury and other neuropsychological conditions. My current research also is investigating how individuals with amnesia (a profound learning and memory impairment) construct a sense of self and experience a sense of continuity in life.

Publications

Grilli, M. D., & Glisky, E. L. (2010). Self-imagining enhances recognition memory in memory-impaired individuals with neurological damage. Neuropsychology, 24(6), 698-710.

The ability to imagine an elaborative event from a personal perspective relies on several cognitive processes that may potentially enhance subsequent memory for the event, including visual imagery, semantic elaboration, emotional processing, and self-referential processing. In an effort to find a novel strategy for enhancing memory in memory-impaired individuals with neurological damage, we investigated the mnemonic benefit of a method we refer to as self-imagining-the imagining of an event from a realistic, personal perspective.

Grilli, M. D., & Verfaellie, M. (2014). Personal semantic memory: insights from neuropsychological research on amnesia. Neuropsychologia, 61, 56-64.

This paper provides insight into the cognitive and neural mechanisms of personal semantic memory, knowledge that is specific and unique to individuals, by reviewing neuropsychological research on stable amnesia secondary to medial temporal lobe damage. The results reveal that personal semantic memory does not depend on a unitary set of cognitive and neural mechanisms. Findings show that autobiographical fact knowledge reflects an experience-near type of personal semantic memory that relies on the medial temporal lobe for retrieval, albeit less so than personal episodic memory. Additional evidence demonstrates that new autobiographical fact learning likely relies on the medial temporal lobe, but the extent to which remains unclear. Other findings show that retrieval of personal traits/roles and new learning of personal traits/roles and thoughts/beliefs are independent of the medial temporal lobe and thus may represent highly conceptual types of personal semantic memory that are stored in the neocortex.

Grilli, M. D., & Glisky, E. L. (2013). Imagining a better memory: Self-imagination in memory-impaired patients. Clinical Psychological Science, 1(1), 93-99.
Grilli, M. D., & Glisky, E. L. (2011). The self-imagination effect: benefits of a self-referential encoding strategy on cued recall in memory-impaired individuals with neurological damage. Journal of the International Neuropsychological Society : JINS, 17(5), 929-33.

Knowledge of oneself is preserved in many memory-impaired individuals with neurological damage. Therefore, cognitive strategies that capitalize on mechanisms related to the self may be particularly effective at enhancing memory in this population. The present study investigated the effect of "self-imagining," imagining an event from a personal perspective, on short and long delayed cued recall in memory-impaired individuals with neurological damage. Sixteen patients intentionally encoded word pairs under four separate conditions: visual imagery, semantic elaboration, other person imagining, and self-imagining. The results revealed that self-imagining led to better performance than other-imagining, semantic elaboration, and visual imagery. Furthermore, the "self-imagination effect" (SIE) was preserved after a 30-min delay and was independent of memory functioning. These findings indicate that self-imagining provides a mnemonic advantage in brain-injured individuals, even those with relatively poor memory functioning, and suggest that self-imagining may tap into mnemonic mechanisms related to the self.

Grilli, M. D. (2017). The association of personal semantic memory to identity representations: insight into higher-order networks of autobiographical contents. Memory (Hove, England), 25(10), 1435-1443.

Identity representations are higher-order knowledge structures that organise autobiographical memories on the basis of personality and role-based themes of one's self-concept. In two experiments, the extent to which different types of personal semantic content are reflected in these higher-order networks of memories was investigated. Healthy, young adult participants generated identity representations that varied in remoteness of formation and verbally reflected on these themes in an open-ended narrative task. The narrative responses were scored for retrieval of episodic, experience-near personal semantic and experience-far (i.e., abstract) personal semantic contents. Results revealed that to reflect on remotely formed identity representations, experience-far personal semantic contents were retrieved more than experience-near personal semantic contents. In contrast, to reflect on recently formed identity representations, experience-near personal semantic contents were retrieved more than experience-far personal semantic contents. Although episodic memory contents were retrieved less than both personal semantic content types to reflect on remotely formed identity representations, this content type was retrieved at a similar frequency as experience-far personal semantic content to reflect on recently formed identity representations. These findings indicate that the association of personal semantic content to identity representations is robust and related to time since acquisition of these knowledge structures.