Scott B Going

Scott B Going

Director, School of Nutritional Sciences and Wellness
Professor, Nutritional Sciences
Professor, Public Health
Professor, Physiology
Professor, Physiological Sciences - GIDP
Professor, BIO5 Institute
Primary Department
Department Affiliations
Contact
(520) 626-3432

Work Summary

Scott Going is an expert in models and methods for assessment of changes in body composition during growth, and with aging, and is currently investigating the effects of chronic exercise versus hormone replacement therapy on bone, soft tissue composition and muscle strength in postmenopausal women, as well as the role of exercise in obesity prevention in children.

Research Interest

Current projects include:The Bone, Estrogen and Strength Training (BEST) study, a randomized prospective study of the effects of hormone replacement therapy on bone mineral density, soft tissue composition, and muscle strength in postmenopausal women (National Institutes of Health). The Profile-based Internet-linked Obesity Treatment study (PILOT), a randomized study of internet support for weight maintenance after weight loss in peri-menopausal women (National Institutes of Health). The Trial of Activity for Adolescent Girls (TAAG) study, a multi-center, school-based activity trial designed to prevent the usual decline in physical activity in adolescent girls (National Institutes of Health). The Adequate Calcium Today (ACT) study, a randomized multi-center study of a behavioral intervention to promote healthy eating, calcium intake and bone development in adolescent girls (United States Department of Agriculture). The Healthy Weight in Adolescents study, a randomized, multi-center study of the effects of a science-based curriculum focused on concepts of energy balance on body weight and composition in adolescent boys and girls (United States Department of Agriculture). The KNEE study, a randomized clinical trial of the effects of resistance exercise on disease progression, pain, and functional capacity in osteoarthritis patients (National Institutes of Health). The STRONG study, a randomized clinical trial of the effects of resistance exercise and Remicaid on disease progression, pain, muscle strength and functional capacity in rheumatoid arthritis patients (Centocor, Inc.). Partners for Healthy Active Children, Campañeros Para Niños Sano y Actives, designed to create and implement research-based physical education and nutrition curricula at YMCA after-school programs and Sunnyside District elementary schools, in alignment with the State o Arizona , Health and Physical Activity standards (Carol M. White Physical Education Program CFDA #84.215F). Longitudinal Changes in Hip Geometry, an observational and experimental cohort study of changes in muscle mass, hip structural parameters and hip bone strength in middle-aged and older women in the Women's Healthy Initiative study (National Institutes of Health).

Publications

Houtkooper, L. B., Lohman, T. G., Going, S. B., & Howell, W. H. (1996). Why bioelectrical impedance analysis should be used for estimating adiposity. American Journal of Clinical Nutrition, 64(3 SUPPL.), 436S-448S.

PMID: 8780360;Abstract:

The whole-body bioelectrical impedance analysis (BIA) approach for estimating adiposity and body fat is based on empirical relations established by many investigators. Properly used, this noninvasive body-composition assessment approach can quickly, easily, and relatively inexpensively provide accurate and reliable estimates of fat-free mass (FFM) and total body water (TBW) in healthy populations. The estimated FFM or TBW values are used to calculate absolute and relative body fat amounts. When different investigators follow the same standard BIA procedures and use the same population and criterion method, similar prediction equations and relatively small prediction errors have been reported for measurement of FFM and TBW (SEE: 1.7-3.0 for FFM and 0.23-1.5 kg for TBW). The BIA approach is most appropriate for estimating adiposity of groups in epidemiologic and field studies but has limited accuracy for estimating body composition in individuals. When used as a simple index (stature2/resistance), BIA is more sensitive and specific for grading average adiposity in groups than some other anthropometric indexes such as the body mass index. Prediction equations based on BIA have been validated and cross validated in children, youths, adults, and the elderly, in primarily white populations and, to a limited extent, in Asian, black, and Native American populations.

Going, S. B., Roe, D., Lohman, T. G., Blew, R., Lee, V., Thuraisingam, R., Mosqueria, L., Wertheim, B., Hetherington-Rauth, M., Funk, J. L., & Bea, J. W. (2018). Comparison of total versus regional body composition using imaging and field measures for predicting inflammation in preadolescent Hispanic girls. JAMA Pediatrics.
Treuth, M. S., Baggett, C. D., Pratt, C. A., Going, S. B., Elder, J. P., Charneco, E. Y., & Webber, L. S. (2009). A longitudinal study of sedentary behavior and overweight in adolescent girls. Obesity, 17(5), 1003-1008.

PMID: 19165170;PMCID: PMC3739452;Abstract:

The aim of this study is to examine sedentary and light activity in relation to overweight in adolescent girls. Adolescent girls were randomly recruited from 36 schools participating in the Trial of Activity for Adolescent Girls (TAAG). Assessments included age, ethnicity, socioeconomic status, and body composition estimated from weight, height, and triceps skinfold. Sedentary and light activity was measured for 6 days using accelerometry in 6th and in 8th grade among two randomly sampled cross-sections of girls. Sedentary activity increased from the 6th to 8th grade by 51.5 min/day. In the 8th grade, a significantly higher number of hours in sedentary activity for each of the 6-days of measurement were evident with higher tertiles of percent body fat (30-35%, 35% fat) (P 0.05), but not across all increasing tertiles of BMI (5th to 85th, 85th to 95th, and 95th percentiles). The increase in sedentary activity was observed on weekdays, but not on weekends for percent body fat tertiles. In the cohort of girls measured in both 6th and 8th grades, the mean cross-sectional coefficient estimates were significant for percent body fat, but not BMI for sedentary and light activities. Adolescent girls from the 6th to 8th grade are shifting their time from light to more sedentary activity as measured by accelerometers. In addition, the increase in sedentary activity is not associated with an adverse effect on BMI or percent body fat. The eventual impact of this shift to a more sedentary lifestyle on body composition and other outcomes needs to be evaluated further.

Teixeira, P. J., Going, S. B., Houtkooper, L. B., Metcalfe, L. L., Blew, R. M., Flint-Wagner, H. G., Cussler, E. C., Sardinha, L. B., & Lohman, T. G. (2003). Resistance training in postmenopausal women with and without hormone therapy. Medicine and Science in Sports and Exercise, 35(4), 555-562.

PMID: 12673136;Abstract:

Purpose: The main purpose of this study was to analyze the impact of a 1-yr resistance-training program on body composition and muscle strength in postmenopausal women, and to describe the impact of hormone replacement therapy (HRT) on body composition changes, with and without exercise. Secondarily, we wanted to study dose-response relationships between measures of program compliance and changes in primary outcomes. Methods: Subjects were postmenopausal women (40 - 66 yr) randomly assigned to an exercise (EX) group (N = 117) and a nonexercise group (N = 116). The EX group participated in a 1 yr trainer-supervised resistance-training program, 60-75 min.d-1, 3 d.wk-1. Lean soft tissue (LST) and fat tissue (FT) changes were measured by dual-energy x-ray absorptiometry and strength by one-repetition maximum testing. Results: Significant (P 0.001) gains in LST were observed for women who exercised, regardless of HRT status, whereas women who did not exercise lost LST (P 0.05) if they were not taking HRT, and gained LST (P = 0.08) if they were on HRT. The only significant FT losses were observed for women who exercised while on HRT (P 0.05). Strength increases were observed at all sites (P 0.001). Total weight lifted by subjects in their training sessions was a significant predictor of changes in LST (P 0.001) and strength (P 0.01). Conclusions: Resistance and weight-bearing exercise significantly changed total and regional body composition in postmenopausal women by increasing LST in all women and decreasing FT in women on HRT. Hormone therapy showed no independent effects on body composition, but it protected nonexercising women from losses in LST. The lean and muscle strength changes observed were partially dependent on the volume of training, as expressed by attendance and total weight lifted in 1 yr of training.

Bea, J. W., Lee, M. C., Hsu, C. H., Going, S. B., Blew, R. M., Lee, V. R., Caan, B., Kwan, M., & Lohman, T. G. (2016). ual energy X-ray absorptiometry spine scans to determine abdominal fat in postmenopausal women. Clinical Densitometry.