Stefano Guerra

Stefano Guerra

Director, Epidemiology
Professor, Public Health
Professor, Medicine - (Tenure Track)
Research Scientist, Respiratory Sciences
Professor, BIO5 Institute
Contact
(520) 626-7411

Work Summary

Stefano Guerra's work includes an epidemiologic study, which used a household-based approach to assess prevalence and longitudinal changes in respiratory health. Other biomarker projects include a study on molecular biomarkers of asthma and COPD from the European Community Respiratory Health Survey.

Research Interest

Stefano Guerra, MD, PhD, is a professor of Medicine, the Director of the Population Science Unit at the Asthma and Airway Disease Research Center, and a leading expert in the natural history and biomarkers of obstructive lung diseases, including asthma and chronic obstructive pulmonary disease (COPD). As principal investigator, he is engaged in the leadership and coordination of multiple studies that use bio-specimens and phenotypic information from independent epidemiological cohorts to characterize the natural history, profile the risk factors, and identify novel biomarkers of lung diseases.

Publications

Rava, M., Le Moual, N., Dumont, X., Guerra, S., Siroux, V., Jacquemin, B., Kauffmann, F., Bernard, A., & Nadif, R. (2015). Serum club cell protein 16 is associated with asymptomatic airway responsiveness in adults: Findings from the French epidemiological study on the genetics and environment of asthma. Respirology (Carlton, Vic.), 20(8), 1198-205.

Club cell secretory protein (CC-16) is a sensitive biomarker of airways epithelium integrity. It has gained interest as a biological marker in chronic lung diseases because of its presumed relationship to inflammation. Little is known about the association between CC-16 serum level and asthma, lung function and airway responsiveness (AR).

Tischer, C., Zock, J., Valkonen, M., Doekes, G., Guerra, S., Heederik, D., Jarvis, D., Norbäck, D., Olivieri, M., Sunyer, J., Svanes, C., Täubel, M., Thiering, E., Verlato, G., Hyvärinen, A., & Heinrich, J. (2015). Predictors of microbial agents in dust and respiratory health in the Ecrhs. BMC pulmonary medicine, 15, 48.

Dampness and mould exposure have been repeatedly associated with respiratory health. However, less is known about the specific agents provoking or arresting health effects in adult populations. We aimed to assess predictors of microbial agents in mattress dust throughout Europe and to investigate associations between microbial exposures, home characteristics and respiratory health.

Balcells, E., Gimeno-Santos, E., de Batlle, J., Ramon, M. A., Rodríguez, E., Benet, M., Farrero, E., Ferrer, A., Guerra, S., Ferrer, J., Sauleda, J., Barberà, J. A., Agustí, À., Rodriguez-Roisin, R., Gea, J., Antó, J. M., & Garcia-Aymerich, J. (2015). Characterisation and prognosis of undiagnosed chronic obstructive pulmonary disease patients at their first hospitalisation. BMC pulmonary medicine, 15, 4.

Under-diagnosis of COPD is an important unmet medical need. We investigated the characteristics and prognosis of hospitalised patients with undiagnosed COPD.

Schultz, E., others, ., Guerra, S., others, ., & Melen, E. (2016). Predictors of Lung function change from childhood to adolescence. European Respiratory Journal.
Chang, E., Stern, D., Willis, A., Guerra, S., Wright, A., & Martinez, F. (2017). Early life risk factors for chronic sinusitis: a longitudinal birth cohort study. Journal of allergy and clinical immunology.