UArizona researchers are expanding the scientific knowledge of cannabis with a focus on two distinct areas – pain and addiction. Included in these teams of researchers are BIO5 members Dr. Tally Largent-Milnes and Dr. Todd Vanderah, director of the UArizona Health Sciences Comprehensive Pain and Addiction Center. Dr. Vanderah spent two decades studying cannabinoids – the compounds found in cannabis. Dr. Largent-Milnes aims to understand how the endocannabinoid system regulates pain in headache disorders, laying the foundation for a potential pathway to novel migraine therapeutics.