Researchers Take A Step Toward Advancing Precision Hormone Therapies To Reduce Alzheimer’s Risk

UArizona Health Sciences Connect
Hormone therapy is the most effective treatment for the symptoms of menopause, which can include hot flashes, night sweats, insomnia, weight gain, and depression. During the study, Dr. Roberta Brinton led a team to examine the effects of individual U.S. Food and Drug Administration-approved hormone therapy medications, including estrogens and progestins, and combination therapies on neurodegenerative disease and found that using natural steroids estradiol or progesterone resulted in greater risk reduction than the use of synthetic hormones. Oral hormone therapies resulted in a reduced risk for combined neurodegenerative diseases, while hormone therapies administered through the skin reduced the risk of developing dementia. The protective effect of long-term therapy lasting longer than one year on Alzheimer’s, Parkinson’s disease and dementia was greater than with short-term therapy of less than one year.