Sinus infections are one of the most common illnesses, so identifying the progression of the common cold to chronic disease lasting longer than 12 weeks is critical in creating therapies that slow the development of a disease affecting nearly 12% of U.S. adults each year. A group lead by Dr. Eugene Chang, vice chair and associate professor in the Department of Otolaryngology-Head and Neck Surgery at the UArizona College of Medicine, was awarded $2.24 million to study a protein in the respiratory tract with a genetic variation strongly associated with these ailments.
Dr. Martha Bhattacharya, a UArizona assistant professor of neuroscience and BIO5 member, discusses her research, her career, and her mentor-ship philosophies with the Daily Wildcat. Dr. Bhattacharya's lab recently linked a gene involved in neurodegeneration to the itch sensation that many mammals experience and has drawn interest from the agribusiness industry for her lab's discovery. In future studies, Dr. Bhattacharya hopes to characterize the role of this gene in our understanding of these itch-sensing pathways in adults.
Dr. Amelia Gallitano, an associate professor in the College of Medicine – Phoenix and BIO5 faculty member, has been included in the Phoenix Business Journal's list of "Outstanding Women in Business." The publication announced this year's Outstanding Women in Business, recognizing 25 women "whose efforts around the region have drawn notice from their peers." Dr. Gallitano studies how genetics and environmental stress affect the development of illnesses such as schizophrenia and mood disorders.
As the human population grows to more than 10 billion in the next 30 years, plant breeders must do everything possible to create crops that are highly productive and nutritious with minimal environmental footprints. Rice will play a critical role in meeting this demand to feed the growing population, so understanding the genetic diversity of these crops is essential. To meet this demand, Drs. David Kudrna and Rod Wing examined the genomes from representatives of 12 of 15 subpopulations of cultivated Asian rice to detect virtually all variation that exists in the pan-genome of cultivated Asian rice.
University of Arizona researchers have begun using a test that can detect the presence of the COVID-19 virus in a person who has no obvious symptoms and possibly determine whether someone was once infected with COVID-19. By studying the antibodies present in a person's blood, the two lead researchers, UA immunologists Dr. Deepta Bhattacharya and Dr. Janko Nikolich-Zugich, hope to answer questions such as what unique antibodies are important to fight the novel coronavirus, how much of the population already had it and recovered or showed no symptoms, and whether it's possible to get reinfected with the virus.
UArizona researchers and staff at all levels are working to assemble COVID-19 collection kits. Led by Dr. David T Harris, Arizona Health Sciences Biorepository executive director, UArizona Department of Immunobiology professor, and BIO5 faculty member, research staff had begun producing the kits over the weekend, ultimately assembling more than 1,600 kits. Dr. Harris said that while assembling the collection kits is fairly easy, it's finding the materials for those kits that's the difficult part. Despite already making nearly 2,000 of these collection kits over the weekend, Dr. Harris said staff aim to assemble 10,000 over the next two weeks.
UArizona Pharmacology professor and BIO5 member Dr. Rajesh Khanna was named a senior member of the National Academy of Inventors (NAI) for his work with Regulonix. Dr. Khanna co-founded and serves as the chief scientific officer of Regulonix. The company is in the process of developing non-opioid therapies for chronic pain relief and management.
Dr. Donna Zhang, a UArizona professor ofPharmacology and Toxicology and BIO5 member, has been formally vested as the Musil Family Endowed Chair For Drug Discovery. Dr. Zhang is an internationally recognized researcher who has spent her career focusing on the transcription factor that regulates the expression of antioxidant proteins, where she has made a number of profound contributions.
Dr. Jeffrey Burgess, a UArizona Mel and Enid Zuckerman College of Public Health researcher and BIO5 member has spent decades researching the connection between firefighters and chemical exposures that can lead to cancer. Dr. Burgess and a team of researchers throughout the U.S. are looking into the genetic changes caused by a firefighter's exposure to chemicals present at fires and different methods that can be used to quickly clear their bodies of these toxins.
Reglagene, a biotech start-up led by BIO5 members Drs. Laurence Hurley and Vijay Gokhale, placed second in the RESI Innovation Challenge during JPM Week in San Francisco. The RESI Challenge featured 30 early stage life science companies from around the world and is designed to help startups refine their business plan, improve go-to-market strategies and increase investor readiness.
A collaborative study led by researchers are the University of Arizona and Henan Normal University in China, traces acoustic communication across the tree of life of land-living vertebrates. Result of the study revealed that the ability to vocalize goes back hundreds of millions of years, associated with a nocturnal lifestyle and has remained stable. Surprisingly, acoustic communication does not seem to drive the formation of new species across vertebrates.
Direct-to-consumer genetic testing is a booming industry. Providers claim that their tests can reveal critical information about your health and ancestry. But how reliable are those claims? In this public presentation, Dr. Ryan Gutenkunst discusses the science behind the hype. He addresses what these companies are actually measuring when you send in a sample and how they use those measurements to learn about your past ancestors and your future health. Dr. Gutenkunst shows us how the complexities of human biology and human history limit what can be learned from genomic tests.
UArizona researcher and BIO5 associate director Dr. Michael Hammer spends every day in a lab studying the gene mutation behind the rare form of epilepsy that afflicted his late daughter Shay. Dr. Hammer studies different models with similar gene variants to understand the genetics and cell formations behind this mutation. His lab uses their findings to assess the effectiveness and reliability of different treatment options to help other children living with this disease.
Our genes can have the effect of increasing our risk for certain diseases, or at it turns out, sometimes they can protect us from them. This has turned out to be the case with a Colombian woman in her 70s who should have developed Alzheimer’s disease by her mid-40s, but has an identified a mutation in her genes that is keeping her from not experiencing dementia.
UA CALS researchers including BIO5 members Drs. Shane Burgess and Patricia Stock, explain the advantages of having a complete genome description of its academic beef herd, after an SNP (single nucleotide polymorphisms) typing project was completed this past May at the V Bar V Agricultural Experiment Station in Coconino County. The goal is to use the extensive data, to help cattle growers improve production by giving them an affordable method for identifying predictable and specific genetic traits in cows.
Swollen Shoot disease is affecting cacao trees in Ghana. UA Plant Sciences professor Dr. Judith Brown, notes that the disease is threatening to affect the supply of chocolate. Dr. Brown is using genome sequencing technology to look deeper into the viruses found to cause damage in cacao plant samples.