In the news / Precision Medicine

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Researchers at the BIO5 Institute are working to determine causes and identify new prevention and treatment strategies for this highly prevalent disease.
 
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More than 6 million people 65 and older have Alzheimer's disease, and almost two-thirds of them are women, according to the Alzheimer's Association. That discrepancy is explained in part by the fact that women tend to live longer than men.
 
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The University of Arizona is a hub of biosciences activity in the region, not just in learning, but in producing solutions that make their way to market and impact society. The following are the primary organizations within UArizona that are fueling research and creating startups.
 
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Throughout the 20 years of BIO5, this institute has connected various campus departments to solve the challenges of a new period of technology growth, research that tells us more than ever, and support students at UArizona.
 
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Mental Illness Awareness Week (October 3-9) culminates with World Mental Health Day on October 10. Several BIO5 researchers are supporting mental health through their basic science and clinical research efforts.
 
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A research study from UArizona College of Medicine-Phoenix and Barrow Neurological Institute at Phoenix Children's Hospital shows the effects of TBI during pregnancy for the child. Researchers were looking at mental health issues, such as anxiety and depression, which were more prevalent in male offspring.
 
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The University of Arizona has been awarded a five-year $60M NIH grant to create a Precision Aging Network that aims to develop more effective brain-aging treatments and interventions targeted to the individual.
 
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Drs. Tally Largent-Milnes and Alicia Allen, researchers with the UArizona Health Sciences Comprehensive Pain and Addiction Center are working toward closing a 20- to 30-year gap in understanding the link between female hormones, pain and addiction, in an effort to improve the quality of women’s lives.
 
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To improve patient frailty assessments and identify cases in which frailty is likely to be reversed with treatment, Dr. Sweitzer is collaborating with Nima Toosizadeh, a biomedical engineer who has been studying frailty with the University of Arizona Center on Aging.
 
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Men and women have similar reasons for becoming – or not becoming – an organ donor, according to a new study. Yet women appear more willing to donate their organs to family members or strangers.
 
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A new UArizona Health Sciences Workforce Education and Training Program, PeerWORKS, has been designed to help people impacted by opioid and substance use disorders. The program will train state-certified health professionals, who are in recovery from a mental illness or substance use disorder, to provide support to those experiencing similar issues.
 
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Dr. E. Fiona Bailey was awarded a five-year, $3.4 million grant from the National Institute on Aging, a division of the National Institutes of Health, to build on her group’s previous research that showed a respiratory workout entailing 30 breaths a day can lower blood pressure.
 
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The Hispanic Health Paradox refers to Hispanics and Latinos tendency toward similar or better survival rates and health outcomes than non-Hispanic whites. The power of social support might also help explain why Hispanics and Latinos often have better disease outcomes than non-Hispanic whites, says Dr. John Ruiz, who studies the phenomenon.
 
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A University of Arizona Health Sciences study has identified the biological mechanism linking long-term arsenic exposure to diseases such as cancer and Type 2 diabetes. The findings could result in potential new targets for drug development.
 
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While the Coronavirus continues to be ever-present in daily life, for many Americans with compromised immune systems, a third shot of one of the mRNA vaccines may provide additional protection from the virus.
 
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The FDA has approved ivosidenib Tablets (Tibsovo) for the treatment of patients with IDH1-mutant cholangiocarcinoma, as detected by an FDA-approved test, according to a press release issued by Servier Pharmaceuticals. This medication, according to Dr. Rachna Shroff of the UArizona Cancer Center, would provide a new treatment for patients.
 
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Tucson is a place of innovation and ever-changing scientific endeavors. CyVerse has received a $1.3 million grant from the National Institute of Food and Agriculture to help transform farming with artificial intelligence. This will aid in the expansion of resilient farming. Additionally, a sleep study is being conducted to utilize breathing exercises to reduce blood pressure and improve cardiovascular health in adults with obstructive sleep apnea.
 
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A recent study by researchers at the UArizona College of Medicine – Phoenix defines a mechanistic role for an understudied bacteria family in gynecologic disease.